Cited by 165Hemoglobin structure and functionNitric Oxide and Endothelin EffectsHeme Oxygenase-1 and Carbon Monoxide

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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

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Allen, Barry W., Stamler, Jonathan S., Piantadosi, Claude A.·2009·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2009.08.002PMC PMC2785508

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Abstract

The protected transport of nitric oxide (NO) by hemoglobin (Hb) links the metabolic activity of working tissue to the regulation of its local blood supply through hypoxic vasodilation. This physiologic mechanism is allosterically coupled to the O(2) saturation of Hb and involves the covalent binding of NO to a cysteine residue in the beta-chain of Hb (Cys beta93) to form S-nitrosohemoglobin (SNO-Hb). Subsequent S-transnitrosation, the transfer of NO groups to thiols on the RBC membrane and then in the plasma, preserves NO vasodilator activity for delivery to the vascular endothelium. This SNO-Hb paradigm provides insight into the respiratory cycle and a new therapeutic focus for diseases involving abnormal microcirculatory perfusion. In addition, the formation of S-nitrosothiols in other proteins may regulate an array of physiological functions.

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Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citation
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,690
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330
Untitled work
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., et al. (2002) · Nature Medicine · doi:10.1038/nm799 · Cited by 1,097
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092
Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050
Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973
The human protein disulphide isomerase family: substrate interactions and functional properties
Ellgaard, L., & Ruddock, L. W. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400311 · Cited by 757
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752
Evolution of adverse changes in stored RBCs
Bennett‐Guerrero, E., Veldman, T. H., Doctor, A., Telen, M. J., Ortel, T. L., Reid, T. S., Mulherin, M. A., Zhu, H., Buck, R. D., Califf, R. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708160104 · Cited by 614
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
Export by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579
Self-citation
Essential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
Liu, L., Yan, Y., Zeng, M., Zhang, J., Hanes, M. A., Ahearn, G. S., McMahon, T., Dickfeld, T. L., Marshall, H. E., Que, L. G., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00131-x · Cited by 546
Regulation of Blood Flow in the Microcirculation
Segal, S. S. (2005) · Microcirculation · doi:10.1080/10739680590895028 · Cited by 537
The erythrocyte as a regulator of vascular tone
Ellsworth, M. L., Forrester, T., Ellis, C. G., & Dietrich, H. H. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.6.h2155 · Cited by 508
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, J. H. (2006) · Blood · doi:10.1182/blood-2005-07-2668 · Cited by 497
CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin
Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481
Self-citation
The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels
Weir, E. K., & Archer, S. L. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781921 · Cited by 466
Nitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462
Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans
Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin
Gibson, Q. H., & Roughton, F. J. W. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005777 · Cited by 396
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334
Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334
Erythrocyte and the Regulation of Human Skeletal Muscle Blood Flow and Oxygen Delivery
González‐Alonso, J., Olsen, D. B., & Saltin, B. (2002) · Circulation Research · doi:10.1161/01.res.0000044939.73286.e2 · Cited by 331
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols
Ignarro, L. J., & Gruetter, C. S. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90297-4 · Cited by 317
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112761 · Cited by 298
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease‐Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12761 · Cited by 290
S -nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked blood
Reynolds, J. D. H., Ahearn, G. S., Angelo, M., Zhang, J., Cobb, F. R., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707958104 · Cited by 282
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281
Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 269
The Plastic Nature of the Vascular Wall: A Continuum of Remodeling Events Contributing to Control of Arteriolar Diameter and Structure
Martinez‐Lemus, L. A., Hill, M. A., & Meininger, G. A. (2009) · Physiology · doi:10.1152/physiol.00029.2008 · Cited by 261
An S -nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
Angelo, M., Singel, D. J., & Stamler, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600942103 · Cited by 233
Self-citation
Potential Oxidative Stress of Gold Nanoparticles by Induced-NO Releasing in Serum
Jia, H., Liu, Y., Zhang, X. J., Han, L., Du, L. B., Tian, Q., & Xu, Y. C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja808033w · Cited by 228
Endogenous S -nitrosothiols protect against myocardial injury
Lima, B., Lam, G. K. W., Xie, L., Diesen, D. L., Villamizar, N. R., Nienaber, J. J., Messina, E., Bowles, D. E., Kontos, C. D., Hare, J. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901043106 · Cited by 223
Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions
Joshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M., & Lancaster, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152149699 · Cited by 216
Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin‐1
Wiley, K. E., & Davenport, A. P. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704815 · Cited by 213
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210
Hemoglobin conformation couples erythrocyte S -nitrosothiol content to O 2 gradients
Doctor, A., Platt, R., Sheram, M. L., Eischeid, A. C., McMahon, T., Maxey, T., Doherty, J., Axelrod, M. J., Kline, J. M., Gurka, M. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407490102 · Cited by 206
Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203
Routes to S -nitroso-hemoglobin formation with heme redox and preferential reactivity in the β subunits
Luchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202
Capillary recruitment in exercise: rate, extent, uniformity, and relation to blood flow
Honig, C. R., Odoroff, C. L., & Frierson, J. L. (1980) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1980.238.1.h31 · Cited by 191
Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans
Roach, R. C., Koskolou, M. D., Calbet, J. A. L., & Saltin, B. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h438 · Cited by 177
THE RATE OF UPTAKE OF CARBON MONOXIDE AND OF NITRIC OXIDE BY NORMAL HUMAN ERYTHROCYTES AND EXPERIMENTALLY PRODUCED SPHEROCYTES
CARLSEN, E. N., & Comroe, J. H. (1958) · The Journal of General Physiology · doi:10.1085/jgp.42.1.83 · Cited by 177
S -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
Stamler, J. S. (2004) · Circulation Research · doi:10.1161/01.res.0000122071.55721.bc · Cited by 170
S-Nitrosothiols signal hypoxia-mimetic vascular pathology
Palmer, L. A., Doctor, A., Chhabra, P., Sheram, M. L., Laubach, V. E., Karlinsey, M. Z., Forbes, M. S., Macdonald, T. L., & Gaston, B. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29444 · Cited by 161
SNO-hemoglobin is not essential for red blood cell–dependent hypoxic vasodilation
Isbell, T. S., Sun, C.-W., Wu, L.-C., Teng, X., Vitturi, D. A., Branch, B. G., Kevil, C. G., Peng, N., Wyss, J. M., Ambalavanan, N., et al. (2008) · Nature Medicine · doi:10.1038/nm1771 · Cited by 157
Hypoxic Vasodilation by Red Blood Cells
Diesen, D. L., Hess, D. T., & Stamler, J. S. (2008) · Circulation Research · doi:10.1161/circresaha.108.176867 · Cited by 145
Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin
McMahon, T., Stone, A. E., Bonaventura, J., Singel, D. J., & Stamler, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000532200 · Cited by 140
Impaired vasodilation by red blood cells in sickle cell disease
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409876102 · Cited by 136
S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric Oxide
Liu, Z., Rudd, M. A., Freedman, J. E., & Loscalzo, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37255-6 · Cited by 131
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity
Gladwin, M. T., Schechter, A. N., Shelhamer, J. H., Pannell, L. K., Conway, D. A., Hrinczenko, B. W., Nichols, J. S., Pease‐Fye, M. E., Noguchi, C. T., Rodgers, G. P., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7637 · Cited by 131
A nitric oxide processing defect of red blood cells created by hypoxia: Deficiency of S-nitrosohemoglobin in pulmonary hypertension
McMahon, T., Ahearn, G. S., Moya, M. M., Gow, A. J., Huang, Y.-C. T., Luchsinger, B. P., Nudelman, R., Yan, Y., Krichman, A. D., Bashore, T. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506957102 · Cited by 130
Vasorelaxation by Red Blood Cells and Impairment in Diabetes
James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B., & Frenneaux, M. P. (2004) · Circulation Research · doi:10.1161/01.res.0000122044.21787.01 · Cited by 125
Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn
Moya, M. P., Gow, A. J., Califf, R. M., Goldberg, R. N., & Stamler, J. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09385-6 · Cited by 123
S-Nitrosothiol measurements in biological systems
Gow, A. J., Doctor, A., Mannick, J. B., & Gaston, B. M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.01.052 · Cited by 123
Bioactivation of Nitroglycerin by the Mitochondrial Aldehyde Dehydrogenase
Chen, Z., & Stamler, J. S. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.05.001 · Cited by 117
A Genetic Analysis of Nitrosative Stress
Foster, M. W., Liu, L., Zeng, M., Hess, D. T., & Stamler, J. S. (2009) · Biochemistry · doi:10.1021/bi801813n · Cited by 114
Autoregulation of blood flow by oxygen lack
Ross, J. M., Fairchild, H. M., Weldy, J., & Guyton, A. C. (1962) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1962.202.1.21 · Cited by 113
Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease
Crawford, J. H., Chacko, B. K., Pruitt, H. M., Piknova, B., Hogg, N., & Patel, R. P. (2004) · Blood · doi:10.1182/blood-2004-03-0880 · Cited by 111
Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110
Expression of Adenosine Triphosphate-Binding Cassette (ABC)??Drug Transporters in Peripheral??Blood Cells
Köck, K., Grube, M., Jedlitschky, G., Oevermann, L., Siegmund, W., Ritter, C. A., & Kroemer, H. K. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746060-00001 · Cited by 105
Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator
Datta, B. N., Tufnell-Barret, T., Bleasdale, R. A., Jones, C. J. H., Beeton, I., Paul, V., Frenneaux, M. P., & James, P. E. (2004) · Circulation · doi:10.1161/01.cir.0000124450.07016.1d · Cited by 102
Enhanced S -Nitroso-Albumin Formation From Inhaled NO During Ischemia/Reperfusion
Ng, E. S. M., Jourd’heuil, D., McCord, J. M., Hernandez, D., Yasui, M., Knight, D., & Kubes, P. (2004) · Circulation Research · doi:10.1161/01.res.0000117771.63140.d6 · Cited by 97
Assessment of nitric oxide signals by triiodide chemiluminescence
Hausladen, A., Rafikov, R., Angelo, M., Singel, D. J., Nudler, E., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611191104 · Cited by 96
How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm
Allen, B. W., & Piantadosi, C. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00310.2006 · Cited by 90
NO Contest
Gladwin, M. T., & Schechter, A. N. (2004) · Circulation Research · doi:10.1161/01.res.0000126697.64381.37 · Cited by 85
Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays
Isbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82
Identification of Stereoselective Transporters for S-Nitroso-L-cysteine
Li, S., & Whorton, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413164200 · Cited by 81
Measurements of nitric oxide on the heme iron and β-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation
Xu, X., Cho, M., Spencer, N. Y., Patel, N. K., Huang, Z., Shields, H. W., King, S. B., Gladwin, M. T., Hogg, N., & Kim‐Shapiro, D. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2033883100 · Cited by 77
Investigations of S-Transnitrosylation Reactions between Low- and High-Molecular-WeightS-Nitroso Compounds and Their Thiols by High-Performance Liquid Chromatography and Gas Chromatography–Mass Spectrometry
Tsikas, D., Sandmann, J., Rossa, S., Gutzki, F., & Frölich, J. C. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4084 · Cited by 70
Inhaled Ethyl Nitrite Prevents Hyperoxia-impaired Postnatal Alveolar Development in Newborn Rats
Auten, R. L., Mason, S. N., Whorton, M. H., Lampe, W. R., Foster, W. M., Goldberg, R. N., Li, B., Stamler, J. S., & Auten, K. M. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-662oc · Cited by 69
S -Nitrosoalbumin–Mediated Relaxation Is Enhanced by Ascorbate and Copper
Gandley, R. E., Tyurin, V. A., Huang, W., Arroyo, A., Daftary, A. R., Harger, G. F., Jiang, J., Pitt, B. R., Taylor, R. N., Hubel, C. A., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000150158.42620.3e · Cited by 66
Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
Tsoukias, N. M. (2008) · Microcirculation · doi:10.1080/10739680802010070 · Cited by 65
Indexes of NO Bioavailability in Human Blood
Lauer, T., Kleinbongard, P., & Kelm, M. (2002) · Physiology · doi:10.1152/nips.01405.2002 · Cited by 64
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Authors: Allen, B. W., Stamler, J. S., & Piantadosi, C. A.
Affiliations: Duke University (US)
Corresponding author: Allen, Barry W.
ORCID: Stamler, Jonathan S.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2009-10
Volume: 15
Issue: 10
Pages: 452-460
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2009.08.002
PMC: PMC2785508
OpenAlex: W2033703576
Cited by: 165
References: 100
Citations by year: 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 23
FWCI: 1.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091876)
Office of Naval Research
National Institute of Allergy and Infectious Diseases (R01AI064789)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords: nitric oxide, hemoglobin, hypoxic vasodilation, S-nitrosohemoglobin, S-nitrosothiols, oxygen saturation, erythrocyte membrane, microvascular blood flow, respiratory cycle, endothelium
MeSH terms: Animals, Endothelium, Vascular, Hemoglobins, Humans, Nitric Oxide, Oxygen, Vasodilation, Nitrosation, Cell Hypoxia, S-Nitrosothiols

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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

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