Cited by 165Hemoglobin structure and functionNitric Oxide and Endothelin EffectsHeme Oxygenase-1 and Carbon Monoxide

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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

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Allen, Barry W., Stamler, Jonathan S., Piantadosi, Claude A.·2009·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2009.08.002PMC PMC2785508

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Abstract

The protected transport of nitric oxide (NO) by hemoglobin (Hb) links the metabolic activity of working tissue to the regulation of its local blood supply through hypoxic vasodilation. This physiologic mechanism is allosterically coupled to the O(2) saturation of Hb and involves the covalent binding of NO to a cysteine residue in the beta-chain of Hb (Cys beta93) to form S-nitrosohemoglobin (SNO-Hb). Subsequent S-transnitrosation, the transfer of NO groups to thiols on the RBC membrane and then in the plasma, preserves NO vasodilator activity for delivery to the vascular endothelium. This SNO-Hb paradigm provides insight into the respiratory cycle and a new therapeutic focus for diseases involving abnormal microcirculatory perfusion. In addition, the formation of S-nitrosothiols in other proteins may regulate an array of physiological functions.

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Authors: Allen, B. W., Stamler, J. S., & Piantadosi, C. A.
Affiliations: Duke University (US)
Corresponding author: Allen, Barry W.
ORCID: Stamler, Jonathan S.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2009-10
Volume: 15
Issue: 10
Pages: 452-460
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2009.08.002
PMC: PMC2785508
OpenAlex: W2033703576
Cited by: 165
References: 100
Citations by year: 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 23
FWCI: 1.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091876)
Office of Naval Research
National Institute of Allergy and Infectious Diseases (R01AI064789)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords: nitric oxide, hemoglobin, hypoxic vasodilation, S-nitrosohemoglobin, S-nitrosothiols, oxygen saturation, erythrocyte membrane, microvascular blood flow, respiratory cycle, endothelium
MeSH terms: Animals, Endothelium, Vascular, Hemoglobins, Humans, Nitric Oxide, Oxygen, Vasodilation, Nitrosation, Cell Hypoxia, S-Nitrosothiols

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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

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