The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease
Open accessAbstract
Disorders of retinal vascular growth and function are responsible for vision loss in a variety of diseases, including diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, and retinal artery or vein occlusion. Over the past decade, a new signaling pathway that controls retinal vascular development has emerged from the study of inherited disorders - in both humans and mice - that are characterized by retinal hypovascularization. This pathway utilizes a glial-derived extracellular ligand, Norrin, that acts on a transmembrane receptor, Frizzled4, a coreceptor, Lrp5, and an auxiliary membrane protein, Tspan12, on the surface of developing endothelial cells. The resulting signal controls a transcriptional program that regulates endothelial growth and maturation. It will be of great interest to determine whether modulating this pathway could represent a therapeutic approach to human retinal vascular disease.
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Cites
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Cited by
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Self-citationHuman Pathophysiological Adaptations to the Space Environment
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Metadata
- Authors
- Ye, X., Wang, Y., & Nathans, J.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 16
- Issue
- 9
- Pages
- 417-425
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2086936956
- Cited by
- 182
- References
- 7
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Ye, X., Wang, Y., & Nathans, J. (2010). The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2010.07.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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