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Cited by 22Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesBioactive natural compounds

Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways

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Rahmani, Arshad Husain, Almatroudi, Ahmad, Allemailem, Khaled S., Alharbi, Hajed Obaid A., Alwanian, Wanian M., Alhunayhani, Basmah Awwadh, Algahtani, Mohammad, Theyab, Abdulrahman, Almansour, Nahlah Makki, Algefary, Ahmed N., Aldeghaim, Solaiman Saleh Ali, Khan, Amjad Ali·2023·Biomedicines
DOI 10.3390/biomedicines11123205PMC PMC10741126
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Abstract

Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatments such as surgery, chemotherapy, and radiotherapy are effective, but, still, cancer is a major problem leading to death and other side effects. However, safer and effective treatment modules are needed to overcome the adverse effects of current treatment modules. In this regard, natural compounds have been recognized to ameliorate diseases by exerting anti-inflammatory, anti-oxidative, and anti-tumor potential through several mechanisms. Mangiferin, a xanthone C-glucoside, is found in several plant species including Mangifera indica (mango), and its role in disease prevention has been confirmed through its antioxidant and anti-inflammatory properties. Furthermore, its anti-cancer-potential mechanism has been designated through modulation of cell signaling pathways such as inflammation, angiogenesis, PI3K/AKT, apoptosis, and cell cycle. This article extensively reviews the anticancer potential of mangiferin in different cancers through the modulation of cell signaling pathways. Moreover, the synergistic effects of this compound with some commonly used anti-cancer drugs against different cancer cells are discussed. More clinical trials should be performed to reconnoiter the anti-cancer potential of this compound in human cancer treatment. Further, understanding of mechanisms of action and the safety level of this compound can help to manage diseases, including cancer.

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  • According to previous cancer-related experiments, MGF most consistently modulates four signaling axes: NF-κB, Nrf2, MAPK and PI3K/Akt.

    “According to previous cancer-related experiments, MGF most consistently modulates four signaling axes that share common upstream triggers and downstream responses (38,39).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [39]

    Section 3.1 reports NF-κB inhibition, section 3.8 reports increased Nrf2 in HL-60 cells, and section 3.6 reports reduced PI3K/Akt and ERK1/2 phosphorylation after mangiferin treatment. These passages support modulation of the named signaling axes in cancer-related experiments, but the review does not establish that these four are the most consistently modulated or that they share common upstream triggers and downstream responses. Section 4.15 also reports no change in JNK1/2 or ERK1/2 phosphorylation in multiple myeloma cells. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Rahmani, A. H., Almatroudi, A., Allemailem, K. S., Alharbi, H. O. A., Alwanian, W. M., Alhunayhani, B. A., Algahtani, M., Theyab, A., Almansour, N. M., Algefary, A. N., Aldeghaim, S. S. A., & Khan, A. A.
Affiliations
  • Qassim University (SA)
  • Security Forces Hospital (SA)
  • Alfaisal University (SA)
  • University of Hafr Al-Batin (SA)
Corresponding author
Rahmani, Arshad Husain
ORCID
Venue
Biomedicines
Publisher
MDPI AG
Published
2023-12-01
Volume
11
Issue
12
Pages
3205
ISSN
2227-9059 (ISSN-L)
DOI
10.3390/biomedicines11123205
PMC
PMC10741126
OpenAlex
W4389222522
Cited by
22
References
16
Citations by year
2026: 7 · 2025: 6 · 2024: 9
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Deanship of Scientific Research, Qassim University
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
mangiferin, mango, anticancer activity, signaling pathways, PI3K/Akt signaling, apoptosis, cell cycle regulation, angiogenesis, inflammation, antioxidant activity, anti-inflammatory activity, drug synergy, natural compounds

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