Cited by 229Fatty Acid Research and HealthPhagocytosis and Immune RegulationImmune Response and Inflammation

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Is Resolution the End of Inflammation?

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Feehan, Karen T., Gilroy, Derek W.·2019·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2019.01.006

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Abstract

Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.

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Authors: Feehan, K. T., & Gilroy, D. W.
Affiliations: University College London (GB)
Corresponding author: Gilroy, Derek W.
ORCID: Feehan, Karen T.
Gilroy, Derek W.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2019-03
Volume: 25
Issue: 3
Pages: 198-214
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2019.01.006
OpenAlex: W2918019780
Cited by: 229
References: 148
Citations by year: 2026: 22 · 2025: 32 · 2024: 40 · 2023: 43 · 2022: 37 · 2021: 30 · 2020: 22 · 2019: 3
FWCI: 3.11
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council (1788941)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inflammation resolution, chronic inflammation, autoimmune disease, innate immunity, adaptive homeostasis, tissue repair, inflammatory mediators
MeSH terms: Acute Disease, Animals, Chronic Disease, Disease Susceptibility, Humans, Immunity, Inflammation, Signal Transduction, Biomarkers, Cytokines, Inflammation Mediators

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Is Resolution the End of Inflammation?

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