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Is Resolution the End of Inflammation?
Open accessAbstract
Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.
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“We now appreciate that switching off inflammation is an equally involved process with distinct signalling and effector pathways all of which impact downstream immune responses (32).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [32]
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Metadata
- Authors
- Feehan, K. T., & Gilroy, D. W.
- Affiliations
- University College London (GB)
- Corresponding author
- Gilroy, Derek W.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 25
- Issue
- 3
- Pages
- 198-214
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2918019780
- Cited by
- 229
- References
- 148
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 40 · 2023: 43 · 2022: 37 · 2021: 30 · 2020: 22 · 2019: 3
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (1788941)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammation resolution, chronic inflammation, autoimmune disease, innate immunity, adaptive homeostasis, tissue repair, inflammatory mediators
- MeSH terms
- Acute Disease, Animals, Chronic Disease, Disease Susceptibility, Humans, Immunity, Inflammation, Signal Transduction, Biomarkers, Cytokines, Inflammation Mediators
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