Epidermal lipids: key mediators of atopic dermatitis pathogenesis

Bhattacharya, Nilika; Sato, William J.; Kelly, Avalon; Ganguli-Indra, Gitali; Indra, Arup K.

doi:10.1016/j.molmed.2019.04.001

Cited by 128Dermatology and Skin DiseasesAdvancements in Transdermal Drug DeliveryContact Dermatitis and Allergies

Epidermal lipids: key mediators of atopic dermatitis pathogenesis

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Bhattacharya, Nilika, Sato, William J., Kelly, Avalon, Ganguli-Indra, Gitali, Indra, Arup K.·2019·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2019.04.001PMC PMC6698381

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Abstract

Skin barrier keeps the “inside-in” and the “outside-out” forming a protective blanket against external insults. Epidermal lipids such as ceramides, fatty acids, triglycerides and cholesterol are integral components in driving the formation and maintenance of epidermal permeability barrier (EPB). A breach in this lipid barrier sets the platform for the subsequent onset and progression of atopic dermatitis (AD). Such lipids are also important in the normal functioning of different organisms, both plants and animals and in diseases including cancer. A double increase in AD rate in the recent years and the chronic nature of this disorder emphasizes the need of this review to shed light on the multifaceted role of the diverse types of lipids in mediating AD pathogenesis.

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Authors: Bhattacharya, N., Sato, W. J., Kelly, A., Ganguli-Indra, G., & Indra, A. K.
Affiliations: Oregon State University (US)
Corresponding author: Indra, Arup K.
ORCID: Indra, Arup K.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2019-06
Volume: 25
Issue: 6
Pages: 551-562
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2019.04.001
PMC: PMC6698381
OpenAlex: W2942746952
Semantic Scholar: 2a48cae18095f240986d1cbe0f0c7d4dfb2a5035
Cited by: 128
References: 104
Citations by year: 2026: 11 · 2025: 18 · 2024: 29 · 2023: 24 · 2022: 19 · 2021: 13 · 2020: 11 · 2019: 2
FWCI: 2.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Oregon State University (OSU) College of Pharmacy
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: atopic dermatitis, epidermal lipids, skin barrier, epidermal permeability barrier, ceramide, fatty acids, triglycerides, cholesterol, pathogenesis
MeSH terms: Animals, Ceramides, Dermatitis, Atopic, Disease Susceptibility, Epidermis, Gene Expression Regulation, Humans, Biomarkers, T-Lymphocyte Subsets, Lipid Metabolism, Metabolic Networks and Pathways

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Epidermal lipids: key mediators of atopic dermatitis pathogenesis

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