The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease
Open accessAbstract
Inflammatory bowel disease (IBD) is associated with the production of reactive species that target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage, ion transport, intermediary metabolism, and mitochondrial function. Precursors of reactive species are derived from organic and inorganic compounds and their cofactors, including amino acids, vitamins, oxygen, nitrite, and sulfate. Nutrition and the gut microbiome fuel this process to a significant extent. The production of reactive species in IBD is reflected by a reduction in systemic free thiols, the major components of the antioxidant machinery. Systemic free thiols are amenable to nutritional or therapeutic intervention. This opens up future avenues for therapeutic modulation of redox status in IBD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., Andrews, E., Ajami, N. J., Bonham, K. S., Brislawn, C. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1237-9 · Cited by 3,143 · cited 1×
“Recent breakthroughs have been made by combining metagenomics, metatranscriptomics, metaproteomics, and metabolomics [81].”
BackgroundNOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · cited 1×
“Both are characterized by inflammation of the gut mucosa caused by an inappropriate immune response triggered by the gut microbiome in genetically susceptible individuals [1].”
BackgroundInflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
The wanderings of a free radical
Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467
Hirata, I., Naito, Y., Takagi, T., Mizushima, K., Suzuki, T., Omatsu, T., Handa, O., Ichikawa, H., Ueda, H., & Yoshikawa, T. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1461-5 · Cited by 72
Saijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M., Andry, C., Granger, D. N., Rodriguez, J., & Feelisch, M. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.009 · Cited by 51
Self-citation
Metadata
- Authors
- Bourgonje, A. R., Feelisch, M., Faber, K. N., Pasch, A., Dijkstra, G., & van Goor, H.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 26
- Issue
- 11
- Pages
- 1034-1046
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W3039592849
- Cited by
- 390
- References
- 10
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease. https://app.cochat.ai/papers/10.1016/j.molmed.2020.06.006
- The paper
- Bourgonje, A. R., Feelisch, M., Faber, K. N., Pasch, A., Dijkstra, G., & van Goor, H. (2020). Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2020.06.006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
