Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

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C ERULOPLASMIN M ETABOLISM AND F UNCTION

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Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

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The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum.

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Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

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The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

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Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury

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Individual dopaminergic neurons show raised iron levels in Parkinson disease

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Sequestration of iron by Lewy bodies in Parkinson's disease

Castellani, R. J., Siedlak, S. L., Perry, G., & Smith, M. A. (2000) · Acta Neuropathologica · doi:10.1007/s004010050001 · Cited by 265 · see citing works

The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism

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Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases

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The Neurological Presentation of Ceruloplasmin Gene Mutations

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Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia

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Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson’s disease

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Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention

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Copper, Ceruloplasmin, Superoxide Dismutase and Iron Parameters in Parkinson's Disease

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Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease

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Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease

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Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY‐5Y cells

Molina‐Holgado, F., Gaeta, A., Francis, P. T., Williams, R. J., & Hider, R. C. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05332.x · Cited by 82 · see citing works

Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson’s disease

Bharucha, K. J., Friedman, J. H., Vincent, A. S., & Ross, E. D. (2008) · Journal of Neurology · doi:10.1007/s00415-009-0063-7 · Cited by 62 · see citing works

Nigral iron deposition occurs across motor phenotypes of Parkinson’s disease

Jin, L., Wang, J., Jin, H. M., Fei, G.-J., Zhang, Y., Chen, W., Zhao, L., Zhao, N., Sun, X., Zeng, M., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03658.x · Cited by 49 · see citing works

Ceruloplasmin and superoxide dismutase (SOD1) in Parkinson's disease: A follow-up study

Tórsdóttir, G., Sveinbjörnsdóttir, S., Kristinsson, J., Snædal, J., & Jøhannesson, T. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.10.015 · Cited by 38 · see citing works

Plasma ceruloplasmin ferroxidase activity correlates with the nigral sonographic area in Parkinson's disease patients: a pilot study

Martínez-Hernández, R., Montes, S., Higuera-Calleja, J., Yescas, P., Boll, M.-C., Diaz-Ruiz, A., & Rios, C. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0535-x · Cited by 34 · see citing works

The role of iron in brain ageing and neurodegenerative disorders

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Wilson's disease and other neurological copper disorders

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Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

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Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Tuo, Q.-Z., Lei, P., Jackman, K. A., Li, X.-L., Xiong, H., Li, X.-L., Liuyang, Z.-Y., Roisman, L. C., Zhang, S.-T., Ayton, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.171 · Cited by 708 · see citing works

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

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Manganese Is Essential for Neuronal Health

Horning, K. J., Caito, S. W., Tipps, K. G., Bowman, A. B., & Aschner, M. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034419 · Cited by 605 · see citing works

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

Mahoney‐Sanchez, L., Bouchaoui, H., Ayton, S., Devos, D., Duce, J. A., & Devedjian, J.-C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101890 · Cited by 558 · see citing works

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Nakamura, T., Naguro, I., & Ichijo, H. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.06.010 · Cited by 523 · see citing works

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497 · see citing works

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Masaldan, S., Bush, A. I., Devos, D., Rolland, A., & Moreau, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 485 · see citing works

Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

Xu, D.-C., Yong, C., Xu, Y., Chen-Yu, S., & Peng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01353-3 · Cited by 498 · see citing works

Ferroptosis and Its Role in Diverse Brain Diseases

Weiland, A., Wang, Y., Wu, W., Lan, X., Han, X., Li, Q., & Wang, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1403-3 · Cited by 469 · see citing works

A delicate balance: Iron metabolism and diseases of the brain

Hare, D. J., Ayton, S., Bush, A. I., & Lei, P. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00034 · Cited by 444 · see citing works

Molecular mechanisms of ferroptosis and their involvement in brain diseases

Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402 · see citing works

Ferroptosis and cell death mechanisms in Parkinson's disease

Guiney, S. J., Adlard, P. A., Bush, A. I., Finkelstein, D. I., & Ayton, S. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.004 · Cited by 337 · see citing works

Ferroptosis in Parkinson’s disease: glia–neuron crosstalk

Wang, Z.-L., Yuan, L., Li, W., & Li, J.-Y. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.02.003 · Cited by 319 · see citing works

Selenium, selenoproteins and neurodegenerative diseases

Cardoso, B. R., Roberts, B. R., Bush, A. I., & Hare, D. J. (2015) · Metallomics · doi:10.1039/c5mt00075k · Cited by 295 · see citing works

Iron and dopamine: a toxic couple

Hare, D. J., & Double, K. L. (2016) · Brain · doi:10.1093/brain/aww022 · Cited by 284 · see citing works

Glutathione peroxidase 4: a new player in neurodegeneration?

Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works

Ferroptosis and Its Potential Role in Human Diseases

Han, C., Liu, Y., Dai, R., Ismail, N., Su, W., & Li, B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00239 · Cited by 274 · see citing works

NRF2, a Superstar of Ferroptosis

Yan, R., Lin, B., Jin, W., Tang, L., Hu, S., & Cai, R. (2023) · Antioxidants · doi:10.3390/antiox12091739 · Cited by 260 · see citing works

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases

Chen, L., Shen, Q., Liu, Y., Zhang, Y., Sun, L., Ma, X., Song, N., & Xie, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02071-0 · Cited by 271 · see citing works

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

Dušek, P., Roos, P. M., Litwin, T., Schneider, S. A., Flaten, T. P., & Aaseth, J. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.05.007 · Cited by 253 · see citing works

Copper pathology in vulnerable brain regions in Parkinson's disease

Davies, K. M., Bohic, S., Carmona, A., Ortega, R., Cottam, V., Hare, D. J., Finberg, J. P. M., Reyes, S., Halliday, G. M., Mercer, J. F. B., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.034 · Cited by 244 · see citing works

Copper Ions and Parkinson’s Disease: Why Is Homeostasis So Relevant?

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Physical activity and the brain: A review of this dynamic, bi-directional relationship

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The mechanism of ferroptosis and its related diseases

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Region‐specific disturbed iron distribution in early idiopathic P arkinson's disease measured by quantitative susceptibility mapping

He, N., Ling, H., Ding, B., Huang, J., Zhang, Y., Zhang, Z., Liu, C., Chen, K., & Yan, F. (2015) · Human Brain Mapping · doi:10.1002/hbm.22928 · Cited by 216 · see citing works

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

Jakaria, M., Belaidi, A. A., Bush, A. I., & Ayton, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15519 · Cited by 212 · see citing works

Copper and Copper Proteins in Parkinson’s Disease

Montes, S., Rivera-Mancia, S., Diaz-Ruiz, A., Tristan-Lopez, L., & Rios, C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/147251 · Cited by 203 · see citing works

Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

Luoqian, J., Yang, W., Ding, X., Tuo, Q., Xiang, Z., Zheng, Z., Guo, Y., Li, L., Guan, P., Ayton, S., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00883-0 · Cited by 189 · see citing works

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

Jiang, H. F., Wang, J., Rogers, J. T., & Xie, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9879-1 · Cited by 183 · see citing works

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

Chen, J., Marks, E. S., Lai, B. C. H., Zhang, Z., Duce, J. A., Lam, L. Q., Volitakis, I., Bush, A. I., Hersch, S. M., & Fox, J. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077023 · Cited by 176 · see citing works

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

Ayton, S., & Lei, P. (2014) · BioMed Research International · doi:10.1155/2014/581256 · Cited by 161 · see citing works

Iron, ferroptosis, and ischemic stroke

Guo, J., Tuo, Q., & Lei, P. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15807 · Cited by 161 · see citing works

The Aging of Iron Man

Ashraf, A., Clark, M., & So, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00065 · Cited by 158 · see citing works

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 154 · see citing works

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

Adlard, P. A., & Bush, A. I. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170662 · Cited by 155 · see citing works

The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

Maung, M. T., Carlson, A., Olea‐Flores, M., Elkhadragy, L., Schachtschneider, K. M., Navarro‐Tito, N., & Padilla‐Benavides, T. (2021) · The FASEB Journal · doi:10.1096/fj.202100273rr · Cited by 157 · see citing works

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

Wong, B. X. W., Tsatsanis, A., Lim, L. Q., Adlard, P. A., Bush, A. I., & Duce, J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114174 · Cited by 153 · see citing works

Motor and cognitive deficits in aged tau knockout mice in two background strains

Lei, P., Ayton, S., Moon, S., Zhang, Q., Volitakis, I., Finkelstein, D. I., & Bush, A. I. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-29 · Cited by 145 · see citing works

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

Sbodio, J. I., Snyder, S. H., & Paul, B. D. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7321 · Cited by 143 · see citing works

Superoxide dismutase and neurological disorders

Chidambaram, S. B., Anand, N., Varma, S. R., Ramamurthy, S., Vichitra, C., Sharma, A., Mahalakshmi, A. M., & Essa, M. M. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.11.007 · Cited by 141 · see citing works

Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics

Davies, K. M., Mercer, J. F. B., Chen, N., & Double, K. L. (2016) · Clinical Science · doi:10.1042/cs20150153 · Cited by 134 · see citing works

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein

Ayton, S., Lei, P., Hare, D. J., Duce, J. A., George, J. L., Adlard, P. A., McLean, C., Rogers, J. T., Cherny, R. A., Finkelstein, D. I., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3439-14.2015 · Cited by 131 · see citing works

Biometals and Their Therapeutic Implications in Alzheimer's Disease

Ayton, S., Lei, P., & Bush, A. I. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0312-z · Cited by 132 · see citing works

The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof

Verwilst, P., Sunwoo, K., & Kim, J. S. (2015) · Chemical Communications · doi:10.1039/c4cc10366a · Cited by 130 · see citing works

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders

David, S., Jhelum, P., Ryan, F., Jeong, S. Y., & Kroner, A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0218 · Cited by 133 · see citing works

Iron as a therapeutic target for Parkinson's disease

Moreau, C., Duce, J. A., Rascol, O., Devedjian, J.-C., Berg, D., Dexter, D. T., Cabantchik, Z. I., Bush, A. I., Devos, D., & the FAIRPARK‐II study group (2018) · Movement Disorders · doi:10.1002/mds.27275 · Cited by 128 · see citing works

Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

studygroups, T. F.-I. A. F.-I., Devos, D., Cabantchik, Z. I., Moreau, C., Danel-Brunaud, V., Mahoney‐Sanchez, L., Bouchaoui, H., Gouel, F., Rolland, A., Duce, J. A., et al. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02138-1 · Cited by 128 · see citing works

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

Genoud, S., Roberts, B. R., Gunn, A. P., Halliday, G. M., Lewis, S. J. G., Ball, H. J., Hare, D. J., & Double, K. L. (2017) · Metallomics · doi:10.1039/c7mt00244k · Cited by 126 · see citing works

Iron supplementation and iron-fortified foods: a review

Man, Y., Xu, T., Adhikari, B., Zhou, C., Wang, Y., & Wang, B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1876623 · Cited by 126 · see citing works

Neurotoxicity of Copper

Bulcke, F., Dringen, R., & Scheiber, I. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-60189-2_16 · Cited by 117 · see citing works

Role of iron in neurodegenerative diseases

Li, K., & Reichmann, H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1508-7 · Cited by 118 · see citing works

Abnormal Copper Homeostasis: Mechanisms and Roles in Neurodegeneration

Manto, M. U. (2014) · Toxics · doi:10.3390/toxics2020327 · Cited by 118 · see citing works

Mitochondrial iron metabolism and neurodegenerative diseases

Cheng, R., Dhorajia, V. V., Kim, J., & Kim, Y. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.11.003 · Cited by 120 · see citing works

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fujita, A., Yamaguchi, H., Yamasaki, R., Cui, Y., Matsuoka, Y., Yamada, K., & Kira, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1251-0 · Cited by 114 · see citing works

Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Zhang, Y., Lu, X., Tai, B., Li, W., & Li, T. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.615372 · Cited by 108 · see citing works

Iron and Neurodegeneration: Is Ferritinophagy the Link?

Biasiotto, G., Lorenzo, D. D., Archetti, S., & Zanella, I. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9473-y · Cited by 104 · see citing works

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons

Bouchaoui, H., Mahoney‐Sanchez, L., Garçon, G., Berdeaux, O., Alleman, L., Devos, D., Duce, J. A., & Devedjian, J.-C. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.086 · Cited by 104 · see citing works

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Finkelstein, D. I., Billings, J. L., Adlard, P. A., Ayton, S., Sedjahtera, A., Masters, C. L., Wilkins, S., Shackleford, D. M., Charman, S. A., Bal, W., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0456-2 · Cited by 103 · see citing works

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

Grolez, G., Moreau, C., Sablonnière, B., Garçon, G., Devedjian, J.-C., Meguig, S., Gelé, P., Delmaire, C., Bordet, R., Defebvre, L., et al. (2015) · BMC Neurology · doi:10.1186/s12883-015-0331-3 · Cited by 101 · see citing works

Is early-life iron exposure critical in neurodegeneration?

Hare, D. J., Arora, M., Jenkins, N. L., Finkelstein, D. I., Doble, P., & Bush, A. I. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.100 · Cited by 100 · see citing works

Does Ceruloplasmin Defend Against Neurodegenerative Diseases?

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Treating Alzheimer's disease by targeting iron

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