The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Sex differences underlying pancreatic islet biology and its dysfunction
Open accessAbstract
BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.
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“and thus increased methylation of the DUSP9 gene could act as a risk factor for insulin resistance and T2DM [83].”
From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [83]
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Metadata
- Authors
- Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F.
- Affiliations
- VA Tennessee Valley Healthcare System (US)
- Joslin Diabetes Center (US)
- University of Alabama at Birmingham (US)
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 15
- Pages
- 82-91
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC6066785
- OpenAlex
- W2806507802
- Cited by
- 133
- References
- 120
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 14 · 2023: 17 · 2022: 23 · 2021: 27 · 2020: 10 · 2019: 7 · 2018: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Juvenile Diabetes Research Foundation United States of America (BX003725, 2 -SRA-2016-270-S-B, R01 DK107444, R01 DK074970, 2-PNF-2016-322-S-B)
- National Institutes of Health (R01 DK105689, 2R24 DK090964-06)
- U.S. Department of Veterans Affairs (BX003744, R01 DK099550, R01 DK103215, R01 DK67536)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- sex differences, pancreatic islets, beta-cell dysfunction, alpha-cell dysfunction, islet heterogeneity, pregnancy, nutrition, diabetes susceptibility, glucose homeostasis
- MeSH terms
- Animals, Diabetes Mellitus, Humans, Islets of Langerhans, Sex Characteristics, Gonadal Hormones
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