Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., et al. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107843 · Cited by 10,792

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Zheng, Y., Ley, S. H., & Hu, F. B. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.151 · Cited by 5,697

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335

Oxidative stress, aging, and diseases

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis

Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60731-5 · Cited by 3,253

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028

Physical activity/exercise and diabetes: A position statement of the American Diabetes Association

Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 948

Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Ma, T., Shen, X., Shi, X., Sakandar, H. A., Quan, K., Li, Y., Jin, H., Kwok, L., Zhang, H., & Sun, Z. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.013 · Cited by 354

Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

Zhao, M., Xie, Y., Gao, W., Li, C., Ye, Q., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192625 · Cited by 135

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

Lian, L., Le, Z., Wang, Z., Chen, Y.-A., Jiao, X., Qi, H., Hejtmancik, J. F., Ma, X., Zheng, Q., & Ren, Y. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.3.16 · Cited by 74

Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Carvalho, C., & Moreira, P. I. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102694 · Cited by 63

Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control

Shamanna, P., Joshi, S., Thajudeen, M., Shah, L., Poon, T., Mohamed, M., & Mohammed, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1485464 · Cited by 56

Mitochondrial Dysfunction in Diabetes: Shedding Light on a Widespread Oversight

Iheagwam, F. N., Joseph, A. J., Adedoyin, E. D., Iheagwam, O. T., & Ejoh, A. S. (2025) · Pathophysiology · doi:10.3390/pathophysiology32010009 · Cited by 53

Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis-Related Proteins

Chen, Z., Luo, J., Jia, M., Chai, Y., & Bao, Y. (2022) · Nutrients · doi:10.3390/nu14245222 · Cited by 44

Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review

Pintarič, M., & Langerholc, T. (2022) · Life · doi:10.3390/life12081187 · Cited by 48

UHPLC-MS/MS identification, quantification of flavonoid compounds from Areca catechu L. extracts and in vitro evaluation of antioxidant and key enzyme inhibition properties involved in hyperglycemia and hypertension

Song, F., Tang, M., Wang, H., Zhang, Y., Zhu, K., Chen, X., Chen, H., & Zhao, X. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115787 · Cited by 40

mTOR Dysregulation, Insulin Resistance, and Hypertension

Stanciu, S. M., Jinga, M., Miricescu, D., Ștefani, C., Nica, R. I., Stănescu-Spînu, I.-I., Văcăroiu, I. A., Greabu, M., & Nica, S. (2024) · Biomedicines · doi:10.3390/biomedicines12081802 · Cited by 44

Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells

Liu, J. S., Wang, X., Zhu, Y., Deng, H., Huang, X., Jayavanth, P., Xiao, Y., Wu, J., & Jiao, R. (2023) · Nutrients · doi:10.3390/nu15183862 · Cited by 39

New insight on dietary strategies to increase insulin sensitivity and reduce diabetes prevalence: an expert perspective and recommendation

Nurkolis, F., Harbuwono, D. S., Taslim, N. A., Soegondo, S., Suastika, K., Sparringa, R. A., Mustika, A., Syam, A. F., Santini, A., Holly, J. M. P., et al. (2025) · Discover Food · doi:10.1007/s44187-025-00422-6 · Cited by 42

Effects of zinc supplementation on glycemic control and oxidative stress in experimental diabetes: A systematic review

Martins, M. D. P. S. C., Oliveira, A. S. D. S. S., Martins, M. D. C. D. C. E., de Carvalho, V. B. L., Rodrigues, L. A. R. L., Arcanjo, D. D. R., dos Santos, M. A. P., Machado, J. S. R., & Rocha, M. D. M. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.08.003 · Cited by 35

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

Fernández‐Aparicio, Á., Correa‐Rodríguez, M., Castellano, J. M., Schmidt‐RioValle, J., Perona, J. S., & González‐Jiménez, E. (2022) · Antioxidants · doi:10.3390/antiox11081517 · Cited by 35

Discussing pathologic mechanisms of Diabetic retinopathy & therapeutic potentials of curcumin and β-glucogallin in the management of Diabetic retinopathy

Rohilla, M., Rishabh, R., Bansal, S., Garg, A., Dhiman, S., Dhankhar, S., Saini, M., Chauhan, S., Alsubaie, N., Batiha, G. E., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115881 · Cited by 29

Exploration of novel DPP-IV inhibitory peptides from discarded eggshell membrane: An integrated in silico and in vitro study

Zhu, L., Li, Z., Ma, M., Huang, X., Guyonnet, V., & Xiong, H. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104036 · Cited by 26

Insulin resistance and cancer: molecular links and clinical perspectives

Caturano, A., Erul, E., Nilo, R., Nilo, D., Russo, V., Rinaldi, L., Acierno, C., Gemelli, M. T., Ricotta, R., Sasso, F. C., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05245-8 · Cited by 27

Incidence of Stress-Induced Hyperglycemia in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Zhang, H., Yue, K., Jiang, Z., Wu, X., Li, X., Luo, P., & Jiang, X. (2023) · Brain Sciences · doi:10.3390/brainsci13040556 · Cited by 25

The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

Liu, N., Li, R., Cao, J., Song, X., Ma, W., Liu, T., Wang, L., Zou, J., Zhang, B., Liu, Z., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01506-x · Cited by 27

The Metabolic Syndrome: An Overview and Proposed Mechanisms

Thomaz, F. S., John, O. D., Sinha, P., Shafie, S. R., & Worrall, S. (2024) · Obesities · doi:10.3390/obesities4030020 · Cited by 29

Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Ashique, S., Mishra, N., Mantry, S., Garg, A., Kumar, N., Gupta, M., Kar, S. K., Islam, A., Mohanto, S., & Subramaniyan, V. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03392-1 · Cited by 25

The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review

Al-Hassani, I., Khan, N. A., Elmenyar, E., Al‐Hassani, A., Rizoli, S. B., Al-Thani, H. A. S., & El-Menyar, A. A. (2024) · Diagnostics · doi:10.3390/diagnostics14232649 · Cited by 23

Integrated in vitro, in silico, and in vivo approaches to elucidate the antidiabetic mechanisms of Cicer arietinum and Hordeum vulgare extract and secondary metabolites

Shahzad, A., Liu, W., Hussain, S., Ni, Y., Cui, K., Sun, Y., Liu, X., Duan, Q., Xia, J., Zhang, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-89642-5 · Cited by 27

Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction

Hughes, F. M., Odom, M. R., Cervantes, A., & Purves, J. T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.920487 · Cited by 26

Antidiabetic and antioxidant effect of magnetic and noble metal nanoparticles of Clitoria ternatea

Sa, N., Tejaswani, P., Pradhan, S. P., Alkhayer, K., Behera, A., & Sahu, P. K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104521 · Cited by 22

Cyanidin-3-O-glucoside as a Nutrigenomic Factor in Type 2 Diabetes and Its Prominent Impact on Health

Bartel, I., Koszarska, M., Strzałkowska, N., Tzvetkov, N. T., Wang, D., Horbańczuk, J. O., Wierzbicka, A., Atanasov, A. G., & Jóźwik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119765 · Cited by 23

A comprehensive review on computational metabolomics: Advancing multiscale analysis through in-silico approaches

Nafie, M. S., Abu-Elsaoud, A. M., & Diab, M. K. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.07.016 · Cited by 20

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Friščić, M., Petlevski, R., Kosalec, I., Madunić, J., Matulić, M., Bučar, F., Pilepić, K. H., & Maleš, Ž. (2022) · Pharmaceuticals · doi:10.3390/ph15050506 · Cited by 20

Association between liver enzymes and type 2 diabetes: a real-world study

Bi, Y., Yang, Y., Yuan, X., Wang, J., Wang, T., Liu, Z., Tian, S., & Sun, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1340604 · Cited by 24

Pyrimidine derivatives as multifaceted antidiabetic agents: A comprehensive review of structure-activity relationships, mechanisms, and clinical potential

Marzouk, M. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117859 · Cited by 17

Preliminary investigation on impact of intergenerational treatment of resveratrol endorses the development of ‘super-pups’

Sharma, A. K., Mukherjee, M., Kumar, A., Sharma, G., Tabassum, F., Akhtar, M. S., Imam, M. T., & Almalki, Z. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121322 · Cited by 17

Sensorimotor dysfunction and postural instability in older adults with type 2 diabetes mellitus: the role of proprioception and neuropathy

Kardm, S. M., Kardm, A. S., Alanazi, Z. A., Alnakhli, H. H., Alkhamis, B. A., & Reddy, R. S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1615399 · Cited by 16

Pleurotus Mushrooms in Nutrition and Health: Clinical and Preclinical Insights for Nutraceutical Development

Araújo, P. L., Araujo, E. D. S., Barreto, E. M. D. A., Alves, J. L. D. B., Souza, K. M., Freire, M. O. D. L., de Souza, R. M. P., & Pereira, F. D. O. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70279 · Cited by 16

Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009–2018

Zhang, Z. J., Chen, M., Cai, D., Fan, M., & Wang, Y. (2025) · Journal of International Medical Research · doi:10.1177/03000605251375557 · Cited by 16

Identification of antidiabetic peptides from broad bean protein: Sequencing using LC-MS-QTOF and in-vitro confirmative studies

Ashraf, Z. U., Gani, A., Shah, A. S., & Gani, A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104903 · Cited by 15

Muscle Oxidative Stress Plays a Role in Hyperthyroidism-Linked Insulin Resistance

Fasciolo, G., Napolitano, G., Aprile, M., Cataldi, S., Costa, V., Tomajoli, M. T. M., Lombardi, A., Meo, S. D., & Venditti, P. (2023) · Antioxidants · doi:10.3390/antiox12030592 · Cited by 15

Effect of glycemic control on cognitive function in patients with type 1 diabetes mellitus: a systematic review and meta-analysis

Hua, W., Du, Z., Lu, T., & Tian, L. (2024) · Systematic Reviews · doi:10.1186/s13643-023-02433-9 · Cited by 16

Antioxidant and Hypoglycemic Activity of Sequentially Extracted Fractions from Pingguoli Pear Fermentation Broth and Identification of Bioactive Compounds

Dai, J., Hu, Y., Si, Q., Gu, Y., Xiao, Z., Ge, Q., & Sha, R. (2022) · Molecules · doi:10.3390/molecules27186077 · Cited by 15

Anti-Diabetic Effect of Lactobacillus Paracasei Isolated from Malaysian Water Kefir Grains

Talib, N., Mohamad, N. E., Yeap, S. K., Ho, C. L., Masarudin, M. J., Abd‐Aziz, S., Izham, M. N. M., Kumar, M. R., Hussin, Y., & Alitheen, N. B. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10159-2 · Cited by 14

Unraveling biomolecules, antidiabetic and antioxidants properties of DelitesTM via pharmacoinformatics and in vitro investigation

Leonardo, J., Putra, P. P., Tallei, T. E., Fatimawali, F., Taslim, N. A., Tjandrawinata, R. R., Lau, V., Mustafa, S., Prieto, M. A., & Nurkolis, F. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100551 · Cited by 14

Meta-inflammation in type 2 diabetes mellitus: unveiling the role of aberrant CD4+ T cells and pro-inflammatory cytokine networks

Shaw, S. K., Sengupta, S., Jha, R., Pattanaik, C., Behera, H., Barik, P. K., Meher, D., Sarangi, R., & Devadas, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603484 · Cited by 13

Type 2 Diabetes Mellitus as a Multisystem Disease: From Insulin Resistance to Organ Crosstalk—A Narrative Review

Fuentes-Barría, H., Aguilera-Eguía, R. A., Flores-Fernández, C., Angarita, L., & Alarcón-Rivera, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040752 · Cited by 19

Type 2 diabetes microenvironment promotes the development of Parkinson’s disease by activating microglial cell inflammation

Zhang, B.-H., Song, C., Tang, X., Tian, M., Liu, Y.-Q., Yan, Z., Duan, R., & Liu, Y.-M. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1422746 · Cited by 13

Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus

Munteanu, C., Kotova, P. D., & Schwartz, B. (2025) · Nutrients · doi:10.3390/nu17030570 · Cited by 17

Microbial Communities in Home-Made and Commercial Kefir and Their Hypoglycemic Properties

Yılmaz, B., Elibol, E., Shangpliang, H. N. J., Özoğul, F., & Tamang, J. P. (2022) · Fermentation · doi:10.3390/fermentation8110590 · Cited by 13

Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer’s disease

Afzal, M., Alharbi, K. S., Alzarea, S. I., Alyamani, N. M., Kazmi, I. A., & Güven, E. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12202 · Cited by 13

Antioxidant, Anti-Diabetic, and Anti-Inflammation Activity of Garcinia livingstonei Aqueous Leaf Extract: A Preliminary Study

Nethengwe, M., Kerebba, N., Okaiyeto, K., Opuwari, C. S., & Oguntibeju, O. O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063184 · Cited by 11

Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review

Anand, S., & Patel, T. (2024) · Discover Oncology · doi:10.1007/s12672-024-01662-1 · Cited by 18

Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities

Rujanapun, N., Jaidee, W., Duangyod, T., Phuneerub, P., Paojumroom, N., Maneerat, T., Pringpuangkeo, C., Ramli, S., & Charoensup, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.797032 · Cited by 11

Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Oxidative Damage via the miR-191-5p/DAPK1/AKT Axis in Type 2 Diabetes

Li, A., Chen, C., Zhang, T., Tian, Y., Cao, Y., Zhao, X., & Wang, L. (2025) · Biomaterials Research · doi:10.34133/bmr.0224 · Cited by 10

Unravelling the role of natural herbs for the management of diabetes mellitus

Firdous, S. M., Irfan, Z., Giri, S., & Asaba, N. S. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01904-4 · Cited by 13

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial

Mansour, A., Sajjadi‐Jazi, S. M., Gerami, H., Khorasanian, A. S., Moalemzadeh, B., Karimi, S., Afrakoti, N. M., Mofid, V., Mohajeri‐Tehrani, M. R., & Hekmatdoost, A. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03618-9 · Cited by 12

Elucidating Key Components and Mechanisms Underlying the Synergistic Anti-Type 2 Diabetes Effect of Morus alba L. and Siraitia grosvenorii Combination: An Integrated In Vitro Enzymology, Untargeted Metabolomics, and Network Pharmacology Approach

He, F., Su, S., Song, R., Li, Y., Zou, L., Li, Z., Xiao, Y., Hou, A.-X., Li, K., & Wang, Y.-L. (2025) · Antioxidants · doi:10.3390/antiox14091065 · Cited by 10

Quantitative Assessment of Pancreatic Fat by Quantitative CT in Type 2 Diabetes Mellitus

Li, Z., Yue, Q., Chen, Y., Zhang, Y., & Wan, Y. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s383783 · Cited by 9

Exploring the cognitive impacts of diabetic neuropathy: a comprehensive review

Mian, M., Salehi, F., Patel, R., Tahiri, J., Bel-Hadj-Kacem, A., Alhaque, A., Eldin, R., & Reddy, P. H. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167892 · Cited by 9

A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)-Associated Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation: Possible Links to Pregestational Prediabetes

Ngema, M., Xulu, N. D., Ngubane, P. S., & Khathi, A. (2024) · Biomedicines · doi:10.3390/biomedicines12061372 · Cited by 7

Obesity and oxidative stress: Implications for female fertility

Heng, N., Zhu, H., Talukder, A. K., & Zhao, S. (2024) · Animal Research and One Health · doi:10.1002/aro2.82 · Cited by 9

Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential

Meng, L., & Wen, W. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s492041 · Cited by 10

Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge

Wadan, A. S., Moshref, A. S., Emam, A. M., Bakry, Y. G., Khalil, B. O., Chaurasia, A., Ibrahim, R. A. H., Badawy, T., & Mehanny, S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04025-x · Cited by 8

Gold nanoparticle encoded with marigold (Tagetes erecta L.) suppressed hyperglycemia -induced senescence in retinal pigment epithelium via suppression of lipid peroxidation

Park, S. Y., Park, K., Oh, J., & Park, G. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.105120 · Cited by 8

Investigations of Limeum Indicum Plant for Diabetes Mellitus and Alzheimer's Disease Dual Therapy: Phytochemical, GC‐MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In‐Vivo Studies

Shamim, T., Asif, H. M., Ejaz, S. A., Hussain, Z., Wani, T. A., Sumreen, L., Abdullah, M., Ahmed, Z., Iqbal, J., Kim, S. J., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301858 · Cited by 7

Nanozymes: Reshaping the landscape of age-related disease therapy through multifaceted redox regulation

Li, Z., Qin, N., Ni, W., Shen, Z., Wang, Y., Shen, J., & Li, Y. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114485 · Cited by 8

Dietary Fibers and Prebiotics for Gut Microbiota Modulation in Type 2 Diabetes: Mechanisms and Therapeutic Potential

Craciun, C. I., Măgureanu, D. C., Bocșan, I. C., Craciun, A. E., Buzoianu, A. D., & Maria Adriana, N. E. A. G. (2026) · Diabetology · doi:10.3390/diabetology7030059 · Cited by 9

Flower extract of Tagetes erecta (marigold) as capping agents for synthesis of magnesium oxide nanoparticles with antioxidant potential

Chandrasekaran, N., Periakaruppan, R., Selvaraj, K. S. V., Shalini, K., & Al‐Dayan, N. (2024) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-024-05668-1 · Cited by 7

Pregestational Prediabetes Induces Maternal Hypothalamic–Pituitary–Adrenal (HPA) Axis Dysregulation and Results in Adverse Foetal Outcomes

Ngema, M., Xulu, N. D., Khathi, A., & Ngubane, P. S. (2024) · International Journal of Molecular Sciences · doi:10.29086/10413/24637 · Cited by 9

Phytochemical profile, antioxidant screening, and antidiabetic effect of pink pepper (Schinus terebinthifolius Raddi) leaves in diabetic mice

Zouaoui, Z., Laabar, A., Asri, S. E., Ennoury, A., Kabach, I., Mondello, L., Cacciola, F., Taghzouti, K., Nhiri, M., & Nhiri, N. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101309 · Cited by 7

SRS 16‐86 promotes diabetic nephropathy recovery by regulating ferroptosis

Qiao, Y., Sun, C., Kan, S., He, L., Wang, Y., Gao, H., Zhang, Y., Cheng, Y., Wang, S., Zhao, L., et al. (2024) · Experimental Physiology · doi:10.1113/ep091520 · Cited by 7

Identification of quality markers for Cyanotis arachnoidea and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation

Hu, J., Feng, Y., Li, B., Wang, F., Qian, Q., Tian, W., Niu, L., & Wang, X. (2023) · PeerJ · doi:10.7717/peerj.15948 · Cited by 6

Effects of hydroalcoholic extract of Fumaria parviflora Lam on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes: A randomized controlled clinical trial

Karimi, A., Abdollahinia, E. D., Ostadrahimi, S., Vajdi, M., Mobasseri, M., Bahrami, A., Tutunchi, H., & Najafipour, F. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106528 · Cited by 6

Assessment of diabetes knowledge, hypoglycaemia awareness, and adherence to insulin pen usage practices among diabetic patients: a cross-sectional study of determinants and educational needs

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Trifolium pratense ‐Derived Exosome Improved Serum Biochemical Parameters and Pancreatic Genes in STZ ‐Induced Diabetic Rats

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