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Cited by 203Pancreatic function and diabetesNatural Antidiabetic Agents StudiesDiabetes Treatment and Management

The DOI matches its Crossref record; 204 of the 212 references it cites were found in a registry or an index.

Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

Lima, Jessica E.B.F., Moreira, Natalia C.S., Sakamoto-Hojo, Elza T.·2022·Mutation Research/Genetic Toxicology and Environmental Mutagenesis
DOI 10.1016/j.mrgentox.2021.503437
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Abstract

Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the combination of genetic and environmental factors, and obesity, lifestyle, and aging are the most relevant risk factors. Hyperglycemia is the main metabolic feature of T2D as a consequence of insulin resistance and β-cell dysfunction. Among the cellular alterations induced by hyperglycemia, the overproduction of reactive oxygen species (ROS) and consequently oxidative stress, accompanied by a reduced antioxidant response and impaired DNA repair pathways, represent essential mechanisms underlying the pathophysiology of T2D and the development of late complications. Mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and inflammation are also closely correlated with insulin resistance and β-cell dysfunction. This review focus on the mechanisms by which oxidative stress, mitochondrial dysfunction, ER stress, and inflammation are involved in the pathophysiology of T2D, highlighting the importance of the antioxidant response and DNA repair mechanisms counteracting the development of the disease. Moreover, we indicate evidence on how nutritional interventions effectively improve diabetes care. Additionally, we address key molecular characteristics and signaling pathways shared between T2D and Alzheimer's disease (AD), which might probably be implicated in the risk of T2D patients to develop AD.

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Crossref · 10.1016/j.mrgentox.2021.503437

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Show all 212 references

Research works printed but not linked: 4

  1. ADA, 2020, Type 2 diabetes - symptoms, causes, treatment, Am. Diabetes Assoc.
  2. Sauriasari, 2015, Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients, Diabetes Res, Clin. Pract., 108, 193
  3. Krokan, 2013, Base excision repair, Cold Spring Harb, Perspect. Biol. Med., 5, 1
  4. Alzheimer’s Association, 2019, Alzheimer’s disease facts and figures Alzheimer’s dementia, Alzheimer’s Dement., 15, 321

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Metadata

Authors
Lima, J. E. B. F., Moreira, N. C. S., & Sakamoto-Hojo, E. T.
ORCID
Sakamoto-Hojo, Elza T.
Venue
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Publisher
Elsevier BV
Published
2022-02
Volume
874-875
Pages
503437
ISSN
1383-5718 (ISSN-L)
DOI
10.1016/j.mrgentox.2021.503437
OpenAlex
W4200140669
Cited by
203
References
212
Citations by year
2026: 42 · 2025: 72 · 2024: 44 · 2023: 30 · 2022: 15
FWCI
5.36
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (142223/2019-0, 309854/2017-2)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
type 2 diabetes, pathophysiology, oxidative stress, reactive oxygen species, insulin resistance, beta-cell dysfunction, hyperglycemia, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, antioxidant response, DNA repair, obesity, diabetes risk factors, dietary intervention, Alzheimer's disease
MeSH terms
Antioxidants, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Inflammation, Insulin Resistance, Risk Factors, Oxidative Stress

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