Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., et al. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107843 · Cited by 10,792

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Zheng, Y., Ley, S. H., & Hu, F. B. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.151 · Cited by 5,697

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335

Oxidative stress, aging, and diseases

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis

Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60731-5 · Cited by 3,253

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028

Physical activity/exercise and diabetes: A position statement of the American Diabetes Association

Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991

Prediabetes: a high-risk state for diabetes development

Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958

Mechanisms, regulation and functions of the unfolded protein response

Hetz, C., Zhang, K., & Kaufman, R. J. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0250-z · Cited by 2,666

Type 2 diabetes: principles of pathogenesis and therapy

Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662

Type 2 diabetes mellitus

DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611

Type 2 diabetes

Chatterjee, S., Khunti, K., & Davies, M. J. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30058-2 · Cited by 2,577

Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33102-1 · Cited by 2,095

Ros and ros-mediated cellular signaling

Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980

Inflammation 2010: New Adventures of an Old Flame

Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,928

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871

Alzheimer's disease

Masters, C. L., Bateman, R., Blennow, K., Rowe, C. C., Sperling, R. A., & Cummings, J. L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.56 · Cited by 1,853

NRF2, a Transcription Factor for Stress Response and Beyond

He, F., Ru, X., & Wen, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134777 · Cited by 1,820

The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives

Tsalamandris, S., Antonopoulos, A. S., Oikonomou, E., Papamikroulis, G.-A., Vogiatzi, G., Papaioannou, S., Deftereos, S., & Tousoulis, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.33.1 · Cited by 1,381

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,284

Active Smoking and the Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis

Willi, C., Bodenmann, P., Ghali, W. A., Faris, P. D., & Cornuz, J. (2007) · JAMA · doi:10.1001/jama.298.22.2654 · Cited by 1,268

Insulin action and resistance in obesity and type 2 diabetes

Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258

Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

Kang, Q., & Yang, C. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101799 · Cited by 1,134

Regulation of mitochondrial biogenesis

Jornayvaz, F. R., & Shulman, G. I. (2010) · Essays in Biochemistry · doi:10.1042/bse0470069 · Cited by 1,119

Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,062

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

Geraldes, P., & King, G. L. (2010) · Circulation Research · doi:10.1161/circresaha.110.217117 · Cited by 1,019

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30068-3 · Cited by 1,017

Iron homeostasis and oxidative stress: An intimate relationship

Galaris, D., Barbouti, A., & Pantopoulos, K. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118535 · Cited by 960

Effects of Aerobic and Resistance Training on Hemoglobin A 1c Levels in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Church, T. S., Blair, S. N., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., Mikus, C. R., Myers, V., Nauta, M., Rodarte, R. Q., et al. (2010) · JAMA · doi:10.1001/jama.2010.1710 · Cited by 944

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Xue, A., Wu, Y., Zhu, Z., Zhang, F., Kemper, K. E., Zheng, Z., Yengo, L., Lloyd‐Jones, L. R., Sidorenko, J., Wu, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04951-w · Cited by 897

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 849

Oxidative stress in Alzheimer’s disease

Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797

O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

Liu, F., Iqbal, K., Grundke-Iqbal, I., Hart, G. W., & Gong, C.-X. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400348101 · Cited by 775

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.

Oguntibeju, O. O. (2019) · Europe PMC (PubMed Central) · Cited by 758

Association of an intensive lifestyle intervention with remission of type 2 diabetes

Gregg, E. W., Chen, H., Wagenknecht, L. E., Clark, J. M., Delahanty, L. M., Bantle, J., Pownall, H. J., Johnson, K. C., Safford, M. M., Kitabchi, A. E., et al. (2012) · JAMA · doi:10.1001/jama.2012.67929 · Cited by 752

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 749

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Vujkovic, M., Keaton, J. M., Lynch, J. A., Miller, D. R., Zhou, J., Tcheandjieu, C., Huffman, J. E., Assimes, T. L., Lorenz, K., Zhu, X., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0637-y · Cited by 741

Biochemical and cellular properties of insulin receptor signalling

Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739

Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial

(2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30162-0 · Cited by 738

The aetiology and molecular landscape of insulin resistance

James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 736

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Hopkins, B. D., Pauli, C., Du, X., Wang, D. G., Li, X., Wu, D., Amadiume, S. C., Goncalves, M. D., Hodakoski, C., Lundquist, M. R., et al. (2018) · Nature · doi:10.1038/s41586-018-0343-4 · Cited by 706

Mechanisms of insulin resistance in obesity

Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Rovira-Llopis, S., Bañuls, C., Diaz-Morales, N., Hernandez-Mijares, A., Rocha, M., & Victor, V. M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.013 · Cited by 657

Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications

Domingueti, C. P., Dusse, L. M. S., Ferriani, M. D. G. C., Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.12.018 · Cited by 647

Type 2 diabetes mellitus in older adults: clinical considerations and management

Bellary, S., Kyrou, I., Brown, J. E., & Bailey, C. J. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00512-2 · Cited by 639

Endoplasmic Reticulum Stress and Type 2 Diabetes

Back, S. H., & Kaufman, R. J. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072909-095555 · Cited by 636

Is Alzheimer’s disease a type 3 diabetes? A critical appraisal

Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621

Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?

Vlassara, H., & Uribarri, J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0453-1 · Cited by 594

Oxidative stress and inflammatory markers in prediabetes and diabetes.

Luc, K., Schramm‐Luc, A., Guzik, T. J., & Mikolajczyk, T. P. (2019) · PubMed · doi:10.26402/jpp.2019.6.01 · Cited by 589

Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis

Pan, A., Wang, Y., Talaei, M., Hu, F. B., & Wu, T. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00316-2 · Cited by 587

Molecular pathways associated with oxidative stress in diabetes mellitus

Ighodaro, O. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.058 · Cited by 585

Effective exercise modality to reduce insulin resistance in women with type 2 diabetes

Cuff, D. J., Meneilly, G. S., Martin, A., Ignaszewski, A., Tildesley, H. D., & Frohlich, J. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.2977 · Cited by 545

Diabetes, oxidative stress and therapeutic strategies

Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.017 · Cited by 543

Oxidative stress: the vulnerable β-cell

Lenzen, S. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360343 · Cited by 535

Hexosamines, insulin resistance, and the complications of diabetes: current status

Buse, M. G. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2005 · Cited by 528

Dietary and nutritional approaches for prevention and management of type 2 diabetes

Forouhi, N. G., Misra, A., Mohan, V., Taylor, R., & Yancy, W. S. (2018) · BMJ · doi:10.1136/bmj.k2234 · Cited by 513

The etiology of oxidative stress in insulin resistance

Hurrle, S., & Hsu, W. H. (2017) · Biomedical Journal · doi:10.1016/j.bj.2017.06.007 · Cited by 510

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

Vosseller, K., Wells, L., Lane, M. D., & Hart, G. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072072399 · Cited by 494

How does diabetes accelerate Alzheimer disease pathology?

Sims-Robinson, C., Kim, B., Rosko, A., & Feldman, E. L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.130 · Cited by 492

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

Simpson, I. A., Chundu, K. R., Davies‐Hill, T., Honer, W. G., & Davies, P. (1994) · Annals of Neurology · doi:10.1002/ana.410350507 · Cited by 490

Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

Rehman, K., & Akash, M. S. H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26097 · Cited by 487

Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants of the NutriNet-Santé Prospective Cohort

Srour, B., Fezeu, L. K., Kesse-Guyot, E., Allès, B., Debras, C., Druesne-Pecollo, N., Chazelas, E., Deschasaux, M., Hercberg, S., Galan, P., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.5942 · Cited by 465

Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk

Chia, C. W., Egan, J. M., & Ferrucci, L. (2018) · Circulation Research · doi:10.1161/circresaha.118.312806 · Cited by 454

mTOR as a central regulator of lifespan and aging

Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 447

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Lytrivi, M., Castell, A., Poitout, V., & Cnop, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.016 · Cited by 434

Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

Nguyen, T. T., Ta, Q. T. H., Nguyen, T. K. O., Nguyen, T. T. D., & Giau, V. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093165 · Cited by 424

Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders

Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R. (2016) · Diabetes Care · doi:10.2337/dc15-1942 · Cited by 418

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β -Cell Dysfunction

Keane, K. N., Cruzat, V. F., Carlessi, R., de Bittencourt, P. I. H., & Newsholme, P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/181643 · Cited by 401

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial

Taheri, S., Zaghloul, H., Chagoury, O., Elhadad, S., Ahmed, S. H., El Khatib, N., Amona, R. A., El Nahas, K., Suleiman, N., Alnaama, A., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30117-0 · Cited by 393

The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 367

The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study

The InterAct Consortium (614230) (2012) · Diabetologia · doi:10.1007/s00125-012-2715-x · Cited by 355

Redox imbalance stress in diabetes mellitus: Role of the polyol pathway

Yan, L. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12001 · Cited by 350

Evaluation of some biochemical changes in diabetic patients

Abou-Seif, M. A. M., & Youssef, A.-A. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.03.030 · Cited by 340

Oxidative DNA damage & repair: An introduction

Cadet, J., & Davies, K. J. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.030 · Cited by 339

Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial

Athinarayanan, S. J., Adams, R. N., Hallberg, S. J., McKenzie, A. L., Bhanpuri, N. H., Campbell, W. W., Volek, J. S., Phinney, S. D., & McCarter, J. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00348 · Cited by 324

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht101 · Cited by 323

Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats

Shao, Q., Meng, L., Lee, S., Tse, G., Gong, M., Zhang, Z., Zhao, J., Zhao, Y., Li, G., & Liu, T. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0964-4 · Cited by 304

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Biessels, G. J., & Kappelle, L. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331041 · Cited by 293

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

Hopkins, B. D., Goncalves, M. D., & Cantley, L. C. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0329-9 · Cited by 288

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

Svilar, D., Goellner, E. M., Almeida, K. H., & Sobol, R. W. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3466 · Cited by 277

Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

Chatterjee, S., & Mudher, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00383 · Cited by 270

Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function

Román-Pintos, L. M., Villegas-Rivera, G., Rodríguez-Carrizález, A. D., Miranda‐Díaz, A. G., & Cardona-Muñóz, E. G. (2016) · Journal of Diabetes Research · doi:10.1155/2016/3425617 · Cited by 261

Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes

Xu, W., Caracciolo, B., Wang, H.-X., Winblad, B., Bäckman, L., Qiu, C., & Fratiglioni, L. (2010) · Diabetes · doi:10.2337/db10-0539 · Cited by 260

DNA damage and repair in type 2 diabetes mellitus

Błasiak, J., Arabski, M., Krupa, R., Woźniak, K., Zadrożny, M., Kasznicki, J., Żurawska-Kliś, M., & Drzewoski, J. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.011 · Cited by 258

Obesity, DNA Damage, and Development of Obesity-Related Diseases

Włodarczyk, M., & Nowicka, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051146 · Cited by 257

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

Pillon, N. J., Loos, R. J. F., Marshall, S. M., & Zierath, J. R. (2021) · Cell · doi:10.1016/j.cell.2021.02.012 · Cited by 247

Effects of diet versus gastric bypass on metabolic function in diabetes

Yoshino, M., Kayser, B. D., Yoshino, J., Stein, R. I., Reeds, D., Eagon, J. C., Eckhouse, S. R., Watrous, J. D., Jain, M., Knight, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2003697 · Cited by 246

Impaired insulin action in the human brain: causes and metabolic consequences

Heni, M., Kullmann, S., Preissl, H., Fritsche, A., & Häring, H.-U. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.173 · Cited by 245

Standards of Medical Care in Diabetes—2021 Abridged for Primary Care Providers

American Diabetes Association (2020) · Clinical Diabetes · doi:10.2337/cd21-as01 · Cited by 244

Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Karimian, M. S., Majeed, M. A., & Sahebkar, A. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0301-4 · Cited by 242

Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains

Pérez, A., Morelli, L., Cresto, J. C., & Castaño, E. M. (2000) · Neurochemical Research · doi:10.1023/a:1007527721160 · Cited by 240

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

Kitamura, T. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.157 · Cited by 225

Insulin action at a molecular level – 100 years of progress

White, M. F., & Kahn, C. R. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101304 · Cited by 221

Targeting endoplasmic reticulum stress in insulin resistance

Salvadó, L., Palomer, X., Barroso, E., & Vázquez‐Carrera, M. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.007 · Cited by 219

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial

Cassidy, S., Thoma, C., Hallsworth, K., Parikh, J. D., Hollingsworth, K. G., Taylor, R., Jakovljević, D. G., & Trenell, M. I. (2015) · Diabetologia · doi:10.1007/s00125-015-3741-2 · Cited by 217

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes

Herder, C., Brunner, E. J., Rathmann, W., Straßburger, K., Tabák, Á. G., Schloot, N. C., & Witte, D. R. (2008) · Diabetes Care · doi:10.2337/dc08-1161 · Cited by 214

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214

Proinflammatory Cytokines in Obesity: Impact of Type 2 Diabetes Mellitus and Gastric Bypass

Catalán, V., Gómez‐Ambrosi, J., Ramírez, B., Rotellar, F., Pastor, C., Silva, C., Rodríguez, A., Gil, M. J., Cienfuegos, J. A., & Frühbeck, G. (2007) · Obesity Surgery · doi:10.1007/s11695-008-9424-z · Cited by 212

Molecular links between Alzheimer’s disease and diabetes mellitus

Yang, Y., & Song, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.009 · Cited by 211

Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

Huynh, T.-P. V., Davis, A. A., Ulrich, J. D., & Holtzman, D. M. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075481 · Cited by 210

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

Bigagli, E., & Lodovici, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5953685 · Cited by 208

Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

Apostolova, N., Iannantuoni, F., Gruevska, A., Muntané, J., Rocha, M., & Víctor, V. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101517 · Cited by 208

Brain insulin signalling in metabolic homeostasis and disease

Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194

Brain glucose transporters, O‐GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06320.x · Cited by 193

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Chornenkyy, Y., Wang, W., Wei, A. L., & Nelson, P. T. (2018) · Brain Pathology · doi:10.1111/bpa.12655 · Cited by 189

Oxidative DNA damage and obesity in type 2 diabetes mellitus

Al-Aubaidy, H. A., & Jelinek, H. F. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0053 · Cited by 183

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

Wang, J., Yang, X., & Zhang, J. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.007 · Cited by 181

A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes

McKenzie, A. L., Hallberg, S. J., Creighton, B. C., Volk, B. M., Link, T. M., Abner, M. K., Glon, R. M., McCarter, J. P., Volek, J. S., & Phinney, S. D. (2017) · JMIR Diabetes · doi:10.2196/diabetes.6981 · Cited by 176

Association Between Childhood Consumption of Ultraprocessed Food and Adiposity Trajectories in the Avon Longitudinal Study of Parents and Children Birth Cohort

Chang, K., Khandpur, N., Neri, D. A., Touvier, M., Huybrechts, I., Millett, C. J., & Vamos, E. P. (2021) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2021.1573 · Cited by 176

The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial

Seyyedebrahimi, S., Khodabandehloo, H., Nasli‐Esfahani, E., & Meshkani, R. (2018) · Acta Diabetologica · doi:10.1007/s00592-017-1098-3 · Cited by 167

Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases

Cao, S. S., Luo, K. L., & Shi, L. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25098 · Cited by 163

Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review

Mittal, K., & Katare, D. P. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.021 · Cited by 161

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160

Risk of Alzheimer’s Disease in Relation to Diabetes: A Population-Based Cohort Study

Wang, K.-C., Woung, L., Tsai, M.-T., Liu, C., Su, Y.-H., & Li, C. (2012) · Neuroepidemiology · doi:10.1159/000337428 · Cited by 155

Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

Yang, P., Feng, J., Peng, Q., Liu, X., & Fan, Z. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9570616 · Cited by 148

Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial

Heiskanen, M. A., Motiani, K. K., Mari, A., Saunavaara, V., Eskelinen, J.-J., Virtanen, K. A., Koivumäki, M., Löyttyniemi, E., Nuutila, P., Kalliokoski, K. K., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4627-x · Cited by 142

Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes

Wang, C., & Wei, Y. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0375-3 · Cited by 140

Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes

Szpigel, A., Hainault, I., Carlier, A., Venteclef, N., Batto, A.-F., Hajduch, É., Bernard, C., Ktorza, A., Gautier, J., Ferré, P., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4462-5 · Cited by 138

Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies.

Shang, X., Scott, D., Hodge, A. M., English, D. R., Giles, G. G., Ebeling, P. R., & Sanders, K. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.140954 · Cited by 137

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

Bhansali, S., Bhansali, A., Walia, R., Saikia, U. N., & Dhawan, V. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00347 · Cited by 134

Mechanism of Oxidative DNA Damage in Diabetes

Simone, S., Gorin, Y. C., Velagapudi, C., Abboud, H. E., & Habib, S. L. (2008) · Diabetes · doi:10.2337/db07-1579 · Cited by 129

Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore

Belosludtsev, K. N., Belosludtseva, N. V., & Dubinin, M. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186559 · Cited by 124

The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease

Stock, A. J., Kasus‐Jacobi, A., & Pereira, H. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1284-4 · Cited by 117

Protein oxidation parameters in type 2 diabetic patients with good and poor glycaemic control

Çakatay, U. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70230-6 · Cited by 116

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

Jacobsen, K. T., & Iverfeldt, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.080 · Cited by 113

Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes

Roszczyc-Owsiejczuk, K., & Zabielski, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.635175 · Cited by 113

The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Bjedov, I., & Rallis, C. (2020) · Genes · doi:10.3390/genes11091043 · Cited by 108

Type 2 diabetes mellitus: Role of melatonin and oxidative stress

Doddigarla, Z., & Ahmad, J. (2014) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2014.09.018 · Cited by 107

Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

Fazzini, F., Lamina, C., Raftopoulou, A., Koller, A., Fuchsberger, C., Pattaro, C., Fabiola Del Greco, M., Döttelmayer, P., Fendt, L., Fritz, J., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13242 · Cited by 107

Protein kinase C in enhanced vascular tone in diabetes mellitus

Kizub, I. V., Klymenko, K., & Soloviev, A. I. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.117 · Cited by 104

Nrf2 and Redox Status in Prediabetic and Diabetic Patients

Jiménez‐Osorio, A. S., Picazo, A., González-Reyes, S., Barrera‐Oviedo, D., Rodríguez-Arellano, M. E., & Pedraza‐Chaverrí, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120290 · Cited by 101

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

Benedict, C., & Grillo, C. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00215 · Cited by 101

Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

Caberlotto, L., Nguyen, T.-P., Lauria, M., Priami, C., Rimondini, R., Maioli, S., Cedazo-Mínguez, Á., Sita, G., Morroni, F., Corsi, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39828-5 · Cited by 99

O-GlcNAcylation, a sweet link to the pathology of diseases

Nie, H., & Yi, W. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900150 · Cited by 98

Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links

Rojas, M., Chávez-Castillo, M., Bautista, J., Ortega, Á., Nava, M., Salazar, J. J., Díaz-Camargo, E. A., Medina, O., Rojas, J., & Bermúdez, V. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i6.745 · Cited by 98

Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes

Pitozzi, V., Giovannelli, L., Bardini, G., Rotella, C. M., & Dolara, P. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00114-3 · Cited by 93

Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic control

Lodovici, M., Giovannelli, L., Pitozzi, V., Bigagli, E., Bardini, G., & Rotella, C. M. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.09.002 · Cited by 92

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging

Zhang, Y., Zhang, J., & Wang, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101376 · Cited by 92

Targeting Mitochondria in Diabetes

Jakovljevic, N. K., Pavlović, K., Jotić, A., Lalic, K. S., Stoiljkovic, M. M., Lukić, L., Milicic, T. J., Macesic, M. V., Gajović, J. S., & Lalic, N. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126642 · Cited by 91

Impaired peripheral glucose homeostasis and Alzheimer's disease

Wijesekara, N., Gonçalves, R. A., Felice, F. G. D., & Fraser, P. E. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.027 · Cited by 84

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

Lipina, C., & Hundal, H. S. (2011) · Diabetologia · doi:10.1007/s00125-011-2127-3 · Cited by 83

IRS2 integrates insulin/ IGF1 signalling with metabolism, neurodegeneration and longevity

White, M. F. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12347 · Cited by 82

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes

Pandey, V. K., Mathur, A., & Kakkar, P. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.11.041 · Cited by 76

PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis

Waldman, M., Nudelman, V., Shainberg, A., Abraham, N. G., Kornwoski, R., Aravot, D. J., Arad, M., & Hochhauser, E. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.10.003 · Cited by 75

Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with Type 2 diabetes and microangiopathy

Adaikalakoteswari, A., Rema, M., Mohan, V., & Balasubramanyam, M. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.04.013 · Cited by 74

The impact of base excision DNA repair in age-related neurodegenerative diseases

Leandro, G. S., Sykora, P., & Bohr, V. A. (2015) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.12.011 · Cited by 72

Depression and risk of type 2 diabetes: the potential role of metabolic factors

Schmitz, N., Deschênes, S. S., Burns, R. J., Smith, K. J., LESAGE, A. D., Strychar, I. M., RABASA-LHORET, R. P. R., Freitas, C., Graham, E. A., Awadalla, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.7 · Cited by 71

Time course of normalization of functional β-cell capacity in the diabetes remission clinical trial after weight loss in type 2 diabetes

Zhyzhneuskaya, S. V., Al-Mrabeh, A., Peters, C., Barnes, A., Aribisala, B., Hollingsworth, K. G., McConnachie, A., Sattar, N., Lean, M. E. J., & Taylor, R. (2020) · Diabetes Care · doi:10.2337/dc19-0371 · Cited by 70

Association between DNA strand breakage and oxidative, inflammatory and endothelial biomarkers in type 2 diabetes

Tatsch, E., Bochi, G. V., Piva, S. J., de Carvalho, J. A. M., Kober, H., Torbitz, V. D., Duarte, T., Signor, C., Coelho, A. C., Duarte, M. M. M. F., et al. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.01.004 · Cited by 69

Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease

Manoel-Caetano, F. S., Xavier, D. J., Evangelista, A. F., Takahashi, P., Collares, C. V. A., Puthier, D., Foss‐Freitas, M. C., Foss, M. C., Donadi, E. A., Passos, G. A. S., et al. (2012) · Gene · doi:10.1016/j.gene.2012.09.090 · Cited by 69

Post-transcriptional markers associated with clinical complications in Type 1 and Type 2 diabetes mellitus

Massaro, J. D., Polli, C. D., Silva, M. C. E., Alves, C. C., Passos, G. A. S., Sakamoto‐Hojo, E. T., Miranda, W. R. D. H., Cézar, N. J. B., Rassi, D. M., Crispim, F., et al. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.03.008 · Cited by 69

Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: A randomized, double-blind, controlled trial

Nazem, M. R., Asadi, M., Jabbari, N., & Allameh, A. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.05.008 · Cited by 68

Oxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2

Grindel, A., Guggenberger, B., Eichberger, L., Pöppelmeyer, C., Gschaider, M., Tosevska, A., Mare, G., Briskey, D. R., Brath, H., & Wagner, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162082 · Cited by 66

Type 1 diabetes mellitus

Lawrence, J., Douglas, P., & Gandy, J. (2016) · doi:10.1002/9781119163411.ch69 · Cited by 61

Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy

Xiang, R., Huang, Y., Zhang, Y., Cong, X., Zhang, Z., Wu, L., & Yu, G. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28962 · Cited by 59

Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial

Golpour, P., Nourbakhsh, M., Mazaherioun, M., Janani, L., Nourbakhsh, M., & Yaghmaei, P. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108120 · Cited by 56

Nutrition and lifestyle intervention in type 2 diabetes: pilot study in the Netherlands showing improved glucose control and reduction in glucose lowering medication

Pot, G. K., Battjes‐Fries, M. C. E., Patijn, O. N., Pijl, H., Witkamp, R. F., de Visser, M., van der Zijl, N. J., de Vries, M., & Voshol, P. J. (2019) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2018-000012 · Cited by 55

Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria

Silzer, T. K., & Phillips, N. R. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.04.004 · Cited by 53

Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus

Pácal, L., Varvařovská, J., Rušavý, Z., Lacigová, S., Štětina, R., Ráček, J., Pomahačová, R., Tanhäuserová, V., & Kaňková, K. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2010.551135 · Cited by 51

Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes

for the GDS Group, Strom, A., Kaul, K., Brüggemann, J., Ziegler, I., Rokitta, I., Püttgen, S., Szendroedi, J., Müssig, K., Roden, M., et al. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.173 · Cited by 51

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain

Docrat, T. F., Nagiah, S., Naicker, N., Baijnath, S., Singh, S. D., & Chuturgoon, A. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173059 · Cited by 49

Effects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes: A Randomized Trial

Sigal, R. J., Kenny, G. P., Boulé, N. G., Wells, G. A., Prud'homme, D., Fortier, M., Reid, R. D., Tulloch, H., Coyle, D., Phillips, P., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00005 · Cited by 48

Dietary Protein Is Important in the Practical Management of Prediabetes and Type 2 Diabetes

Campbell, A. P., & Rains, T. M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.194878 · Cited by 48

Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes

Dogan Turacli, I., Candar, T., Yuksel, E. B., Kalay, S., Oguz, A. K., & Demirtas, S. (2018) · Biochimie · doi:10.1016/j.biochi.2018.08.002 · Cited by 46

Inter‐relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus

Choi, S. W., Benzie, I. F. F., Lam, C. S. Y., Chat, S. W., Lam, J. K. Y., Yiu, C. H., Kwan, J. J., Tang, Y. H., Yeung, G. S. P., Yeung, M. W., et al. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01647.x · Cited by 45

Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study

Memon, A. A., Sundquist, J., Hedelius, A., Palmér, K., Wang, X., & Sundquist, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-84132-w · Cited by 44

Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer’s Disease

Santiago, J. A., Bottero, V., & Potashkin, J. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01273 · Cited by 43

Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria

Skuratovskaia, D., Komar, A., Vulf, M. A., & Litvinova, L. S. (2020) · PeerJ · doi:10.7717/peerj.9741 · Cited by 37

Progression to Type 2 Diabetes in Women With a Known History of Gestational Diabetes: Systematic Review and Meta-analysis

Vounzoulaki, E., Khunti, K. K., Abner, S. C., Tan, B. K., Davies, M. J., & Gillies, C. L. (2020) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000721620.59805.5c · Cited by 37

Analysis of oxidative DNA damage and its repair in Polish patients with diabetes mellitus type 2: Role in pathogenesis of diabetic neuropathy

Merecz-Sadowska, A., Markiewicz, Ł., Śliwińska, A., Kosmalski, M., Kasznicki, J., Drzewoski, J., & Majsterek, I. (2015) · Advances in Medical Sciences · doi:10.1016/j.advms.2015.04.001 · Cited by 36

Role of pseudohypoxia in the pathogenesis of type 2 diabetes

Song, J., Yang, X., & Yan, L. (2019) · Hypoxia · doi:10.2147/hp.s202775 · Cited by 36

ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E

Hernandez, J. D., Li, T., Rau, C. M., LeSuer, W. E., Wang, P., Coletta, D. K., Madura, J. A., Jacobsen, E. A., & Filippis, E. D. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00801-w · Cited by 36

Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes

Cao, Z., Wu, Z., Hu, C., Zhang, M., Wang, W.-Z., & Hu, X. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000583 · Cited by 32

Assessment of DNA damage and mRNA/miRNA transcriptional expression profiles in hyperglycemic versus non-hyperglycemic patients with type 2 diabetes mellitus

Xavier, D. J., Takahashi, P., Evangelista, A. F., Foss‐Freitas, M. C., Foss, M. C., Donadi, E. A., Passos, G. A. S., & Sakamoto‐Hojo, E. T. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.01.016 · Cited by 29

Lipid and protein oxidation products, antioxidant status and vascular complications in poorly controlled type 2 diabetes

Bigagli, E., Raimondi, L., Mannucci, E., Colombi, C., Bardini, G., Rotella, C. M., & Lodovici, M. (2012) · The British Journal of Diabetes · doi:10.1177/1474651411435588 · Cited by 28

Characteristic Metabolic Alterations Identified in Primary Neurons Under High Glucose Exposure

Zhao, L., Dong, M., Wang, D., Ren, M., Zheng, Y., Zheng, H. X., Li, C., & Gao, H. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00207 · Cited by 26

AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population

Chen, H., Sun, C., Guo, W., Meng, R., Du, H., Qi, Q., Gu, X., Li, L., Zhang, K., Zhu, D., et al. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.021 · Cited by 25

Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population

Sun, C., Liu, X., Zhang, H., Guo, W., Cai, Z., Chen, H., Zhang, K., Zhu, D., & Wang, Y. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.05.005 · Cited by 25

Mitochondrial DNA Copy Number in Peripheral Blood Is Reduced in Type 2 Diabetes Patients with Polyneuropathy and Associated with a MIR499A Gene Polymorphism

Latini, A., Borgiani, P., Benedittis, G. D., D’Amato, C., Greco, C., Lauro, D., Novelli, G., Spallone, V., & Ciccacci, C. (2020) · DNA and Cell Biology · doi:10.1089/dna.2019.5326 · Cited by 25

Serum 8-hydroxy-2′-deoxyguanosine (8-oxo-dG) levels are elevated in diabetes patients

Sun, J., Lou, X., Wang, H., Sollazzo, A., Harms‐Ringdahl, M., Skog, S., He, E., & Haghdoost, S. (2015) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-015-0301-8 · Cited by 24

Increased 8-hydroxy-2’-deoxyguanosine in leukocyte DNA from patients with type 2 diabetes and microangiopathy

Ye, X., Jiang, R., Zhang, Q.-Q., Wang, R., Yang, C., Ma, J., & Du, H. (2016) · Journal of International Medical Research · doi:10.1177/0300060515621530 · Cited by 24

One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus

Xavier, D. J., Takahashi, P., Manoel-Caetano, F. S., Foss‐Freitas, M. C., Foss, M. C., Donadi, E. A., Passos, G. A. S., & Sakamoto‐Hojo, E. T. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.06.004 · Cited by 23

Mitochondrial DNA copy number associates with insulin sensitivity and aerobic capacity, and differs between sedentary, overweight middle-aged males with and without type 2 diabetes

Constantin‐Teodosiu, D., Constantin, D., Pelsers, M. M. A. L., Verdijk, L. B., van Loon, L. J. C., & Greenhaff, P. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0473-2 · Cited by 22

The Dose-Response Relationship between Alcohol Consumption and the Risk of Type 2 Diabetes among Asian Men: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Han, M. (2020) · Journal of Diabetes Research · doi:10.1155/2020/1032049 · Cited by 21

Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes

Cho, S. B., Koh, I., Nam, H., Jeon, J., Lee, H. K., & Han, B. (2017) · Scientific Reports · doi:10.1038/srep43203 · Cited by 20

Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue

Lv, B., Bao, X., Li, P., Lian, J., Wu, Y., An, T., Zhang, J., Yang, X., Wang, T., Zhu, J., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.558344 · Cited by 20

Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes

Cerf, M. E. (2020) · Metabolites · doi:10.3390/metabo10110444 · Cited by 19

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Bosi, E., Marselli, L., Luca, C. D., Suleiman, M., Tesi, M., Ibberson, M. R., Eizirik, D. L., Cnop, M., & Marchetti, P. (2020) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqaa097 · Cited by 18

Poly(ADP-ribosylated) proteins in mononuclear cells from patients with type 2 diabetes identified by proteomic studies

Giorgi, A., Tempera, I., Napoletani, G., Drovandi, D., Potestà, C., Martire, S., Mandosi, E., Filardi, T., Schininà, M. E., Morano, S., et al. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1013-y · Cited by 17

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 948

Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Ma, T., Shen, X., Shi, X., Sakandar, H. A., Quan, K., Li, Y., Jin, H., Kwok, L., Zhang, H., & Sun, Z. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.013 · Cited by 354

Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

Zhao, M., Xie, Y., Gao, W., Li, C., Ye, Q., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192625 · Cited by 135

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

Lian, L., Le, Z., Wang, Z., Chen, Y.-A., Jiao, X., Qi, H., Hejtmancik, J. F., Ma, X., Zheng, Q., & Ren, Y. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.3.16 · Cited by 74

Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Carvalho, C., & Moreira, P. I. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102694 · Cited by 63

Oxidative Stress, DNA Damage and Repair Pathways in Patients with Type 2 Diabetes Mellitus

Sakamoto‐Hojo, E. T. (2020) · BiblioBoard Library Catalog (Open Research Library)

Molecular and cellular processes connecting type 2 diabetes to Alzheimer’s disease, focusing on oxidative stress, metabolic dysfunction, and neurodegeneration

Ono, R. M. D. S., Lima, J. E. B. D. F., de Lira, J. A. S. P., Sanches, F. C., Piassi, L. D. O., Coelho, L. B. V., Moreira, N. C. D. S., & Sakamoto‐Hojo, E. T. (2026) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2025-0233

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Burgos‐Morón, E., Abad‐Jiménez, Z., Marañón, A., Iannantuoni, F., Escribano‐López, I., López‐Domènech, S., Salom, C., Jover, A., Llabata, V. M., Torres, I. R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091385 · Cited by 612

Mesenchymal Stem Cells Benefit Diabetes and Alzheimer’s Disease

Li, M., & Ikehara, S. (2015) · International Journal of Chronic Diseases & Therapy · doi:10.19070/2572-7613-150001e

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

Bhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 753