The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Non-targeted effects of ionising radiation—Implications for low dose risk
Open accessAbstract
Non-DNA targeted effects of ionizing radiation, which include genomic instability, and a variety of bystander effects including abscopal effects and bystander mediated adaptive response, have raised concerns about the magnitude of low-dose radiation risk. Genomic instability, bystander effects and adaptive responses are powered by fundamental, but not clearly understood systems that maintain tissue homeostasis. Despite excellent research in this field by various groups, there are still gaps in our understanding of the likely mechanisms associated with non-DNA targeted effects, particularly with respect to systemic (human health) consequences at low and intermediate doses of ionizing radiation. Other outstanding questions include links between the different non-targeted responses and the variations in response observed between individuals and cell lines, possibly a function of genetic background. Furthermore, it is still not known what the initial target and early interactions in cells are that give rise to non-targeted responses in neighbouring or descendant cells. This paper provides a commentary on the current state of the field as a result of the Non-targeted effects of ionizing radiation (NOTE) Integrated Project funded by the European Union. Here we critically examine the evidence for non-targeted effects, discuss apparently contradictory results and consider implications for low-dose radiation health effects.
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Cites
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Space radiation risks for astronauts on multiple International Space station missions
Cucinotta, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096099 · Cited by 203
Interplay of space radiation and microgravity in DNA damage and DNA damage response
Moreno-Villanueva, M., Wong, M., Lu, T., Zhang, Y., & Wu, H. (2017) · npj Microgravity · doi:10.1038/s41526-017-0019-7 · Cited by 181
A New Approach to Reduce Uncertainties in Space Radiation Cancer Risk Predictions
Cucinotta, F. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0120717 · Cited by 79
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Cucinotta, F. A., Alp, M., Rowedder, B., & Kim, M.-H. Y. (2015) · Life Sciences in Space Research · doi:10.1016/j.lssr.2015.04.002 · Cited by 71
Metadata
- Authors
- Kadhim, M., Salomaa, S., Wright, E., Hildebrandt, G., Belyakov, O. V., Prise, K. M., & Little, M. P.
- Venue
- Mutation Research/Reviews in Mutation Research
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 752
- Issue
- 2
- Pages
- 84-98
- ISSN
- 1383-5742 (ISSN-L)
- OpenAlex
- W2067327293
- Cited by
- 229
- References
- 9
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- green
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