Development of poly(lactic acid) nanostructured membranes for the controlled delivery of progesterone to livestock animals
Abstract
Solution blow spinning (SBS) is a novel technology feasible to produce nanostructured polymeric membranes loaded with active agents. In the present study, nanofibrous mats of poly(lactic acid) (PLA) loaded with progesterone (P4) were produced by SBS at different P4 concentrations. The spun membranes were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). The in vitro releasing of P4 was evaluated using high-performance liquid chromatography (HPLC). Interactions between progesterone and PLA were confirmed by rheological measurements of the PLA/P4 solutions and in the spun mats by microscopy (SEM), thermal (DSC) and spectral (FTIR) analyses. SEM micrographs provided evidences of a smooth and homogeneous structure for nanostructured membranes without progesterone crystals on fiber surface. FTIR spectroscopy indicated miscibility and interaction between the ester of PLA and the ketone groups of the P4 in the nanofibers. X-ray analysis indicated that the size of PLA crystallites increased with progesterone content. Finally, by in vitro release experiments it was possible to observe that the progesterone releasing follows nearly first-order kinetics, probably due to the diffusion of hormone into PLA nanofibers.
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Compared with electrospinning, fabrication of drug-loaded fibrous membranes via SBS exhibits more prominent potential for large-scale production; SBS process enables preparation of nanofibrous membranes without need for high-voltage power supplies or conductive collectors; thus SBS demonstrates more competitive advantages in mass production of PLCL-based drug-loaded fibrous membranes.
“Compared with electrospinning, the fabrication of drug-loaded fibrous membranes via SBS exhibits more prominent potential for large-scale production [222]. The SBS process enables the preparation of nanofibrous membranes without the need for high-voltage power supplies or conductive collectors [223]. Thus, SBS demonstrates more competitive advantages in the mass production of PLCL-based drug”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [224]
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“Thus, SBS demonstrates more competitive advantages in the mass production of PLCL-based drug-loaded fi brous membranes [224].”
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Kamothi, D. J., Vaidhya, A., Smaraki, N., & Jogi, H. R. (2025) · Methods in pharmacology and toxicology · doi:10.1007/978-1-0716-4554-3_17 · Cited by 2 · see citing works
Long-acting drug delivery systems: applications for sexual and reproductive health
Galal, S., Jones, C., & Coward, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821749-8.00013-6
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Nanotechnology in Animal Genetics, Breeding and Reproduction
Kumar, P., Singh, P., Verma, N., Bhardwaj, A., & Nayan, V. (2026) · Smart nanomaterials technology · doi:10.1007/978-981-95-4542-1_2
Urbanek, O., Osial, M. E., Zaszczyńska, A., Lustyk, Ł., & Pavone, M. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119734
- Authors
- Oliveira, J. E., Medeiros, E. S., Cardozo, L., Voll, F., Madureira, E. H., Mattoso, L. H. C., & Assis, O. B. G.
- Affiliations
- Embrapa Instrumentação (BR)
- Universidade Federal da Paraíba (BR)
- Universidade Estadual de Maringá (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Mattoso, Luiz Henrique Capparelli
- ORCID
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 33
- Issue
- 2
- Pages
- 844-849
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2008312827
- Cited by
- 70
- References
- 30
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 2
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Financiadora de Estudos e Projetos
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- polylactic acid, progesterone, solution blow spinning, nanofibrous membranes, controlled drug release, drug-polymer interactions, first-order release kinetics, nanofiber morphology
- MeSH terms
- Animals, Calorimetry, Differential Scanning, Crystallization, Drug Carriers, Kinetics, Microscopy, Electron, Scanning, Polyesters, Polymers, Progesterone, Viscosity, X-Ray Diffraction, Spectroscopy, Fourier Transform Infrared, Lactic Acid, Transition Temperature, Nanostructures, Nanofibers
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