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In vitro and in vivo evaluation of SU-8 biocompatibility
Open accessAbstract
SU-8 negative photoresist is a high tensile strength polymer that has been used for a number of biomedical applications that include cell encapsulation and neuronal probes. Chemically, SU-8 comprises, among other components, an epoxy based monomer and antimony salts, the latter being a potential source of cytotoxicity. We report on the in vitro and in vivo evaluation of SU-8 biocompatibility based on leachates from various solvents, at varying temperature and pH, and upon subcutaneous implantation of SU-8 substrates in mice. MTT cell viability assay did not exhibit any cytotoxic effects from the leachates. The hemolytic activity of SU-8 is comparable to that of FDA approved implant materials such as silicone elastomer, Buna-S and medical steel. In vivo histocompatibility study in mice indicates a muted immune response to subcutaneous SU-8 implants.
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Cites
Surface Chemistry Influences Implant Biocompatibility
Tang, L., Thevenot, P., & Hu, W. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608783790901 · Cited by 800
Cited by
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
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Li, J., & Pumera, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01062f · Cited by 303
In Vivo Self‐Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters
Kim, D. H., Shin, H. J., Lee, H., Jeong, C. K., Park, H., Hwang, G., Lee, H., Joe, D. J., Han, J. H., Lee, S. H., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700341 · Cited by 245
Zhou, T., Hong, G., Fu, T.-M., Yang, X., Schuhmann, T. G., Viveros, R. D., & Lieber, C. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705509114 · Cited by 227
Thinking Small: Progress on Microscale Neurostimulation Technology
Pancrazio, J. J., Deku, F., Ghazavi, A., Stiller, A. M., Rihani, R., Frewin, C. L., Varner, V. D., Gardner, T. J., & Cogan, S. F. (2017) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/ner.12716 · Cited by 60
Metadata
- Authors
- Nemani, K. V., Moodie, K. L., Brennick, J. B., Su, A., & Gimi, B.
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 33
- Issue
- 7
- Pages
- 4453-4459
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W1986364032
- Cited by
- 262
- References
- 1
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- green
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