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hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation
Open accessAbstract
The exploration of effective spinal cord injury (SCI) healing still remain a great challenge due to the high morbidity, complex pathology and unclear targets. Human umbilical cord mesenchymal stem cells (hucMSC) play an important role in tissue regeneration. However, transplanting stem cells has a potential risk of teratogenicity. Recent studies have suggested that exosomes secreted by stem cells may contribute to tissue injury repair. We hypothesized that the application of hucMSC derived exosomes may be a potential way for SCI treatment. Our studies showed the hucMSC derived exosomes with a mean particle size of 70 nm could effectively trigger the bone marrow derived macrophage (BMDM) polarization from M1 to a M2 phenotype. In vivo studies demonstrated that the hucMSC derived exosomes could improve the functional recovery after SCI through down-regulation of the inflammatory cytokines, such as TNF-α, MIP-1α, IL-6 and IFN-γ. Collectively, our findings indicated that hucMSC derived exosomes could facilitate spinal cord injury healing via attenuating the inflammation of the injury region. Our results provided a new perspective and therapeutic strategy for the use of hucMSC derived exosomes in soft tissue repair.
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“Several studies reported that MSC-derived exosomes efficiently suppressed detrimental immune response in inflamed tissues, and promoted the survival and regeneration of injured cells [[73], [74], [75]].”
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Metadata
- Authors
- Sun, G., Li, G., Li, D., Huang, W., Zhang, R., Zhang, H., Duan, Y., & Wang, B.
- Affiliations
- Jinan University (CN)
- Corresponding author
- Duan, Yuanyuan
- Wang, Baocheng
- Venue
- Materials Science and Engineering C
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 89
- Pages
- 194-204
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2796692968
- Cited by
- 314
- References
- 65
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 54 · 2023: 43 · 2022: 46 · 2021: 72 · 2020: 30 · 2019: 24 · 2018: 3
- FWCI
- 24.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 254 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Materials Science and Engineering C (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31670969)
- Guangdong Innovative and Entrepreneurial Research Program (201301S0105240297)
- Key Program of Traditional Chinese Medicine of Guangdong Province (20173018)
- National Science Foundation for Young Scientists of China (31500734)
- China Postdoctoral Science Foundation (2015M572411)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- spinal cord injury, exosomes, human umbilical cord mesenchymal stem cells, functional recovery, inflammation, macrophage polarization, M1/M2 macrophages, inflammatory cytokines, TNF-α, interleukin-6, interferon-gamma, MIP-1α, tissue regeneration
- MeSH terms
- Animals, Arginase, Female, Humans, Inflammation, Lipopolysaccharides, Locomotion, Macrophages, Mice, Inbred C57BL, Phenotype, Spinal Cord Injuries, Umbilical Cord, Cytokines, Cell Polarity, Recovery of Function, Mice, Nitric Oxide Synthase Type II, Exosomes, Mesenchymal Stem Cells, Tetraspanin 30
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