Polypyrrole-coated poly(l-lactic acid-co-ε-caprolactone)/silk fibroin nanofibrous nerve guidance conduit induced nerve regeneration in rat
Abstract
According to our previous study, polypyrrole (Ppy) possessed good conductivity and non-cytotoxicity. In this study, the surface of electrospun poly(l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) was coated with Ppy to fabricate Ppy-coated nerve guidance conduit (NGC). Firstly, the presence of Ppy on the prepared NGC was characterized and confirmed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopic spectra (XPS) and Fourier transforms infrared spectroscopy (FTIR). Subsequently, Ppy-coated NGC was used to repair a 10 mm sciatic nerve gap in vivo. 4 and 12 weeks after implantation, the regenerated nerve tissues on defect sites were removed and sectioned for further evaluation. Histological analysis with hematoxylin-eosin (HE), toluidine blue (TB), and luxol fast blue (LFB) staining indicated that the coated Ppy could promote SCs proliferation in early post-surgery, and enhance myelin formation in later post-surgery. In consideration of immunofluorescence and morphology observation with SEM and TEM, it showed that the nerve regeneration of Ppy-coated NGC group was close to autograft group, which was better than PLCL/SF NGC. In addition, walking track analysis indicated that Ppy-coated NGC group showed a similar performance compared with the autograft group, and significantly better than PLCL/SF NGC group. These promising results showed the potential of Ppy-coated NGC in peripheral nerve regeneration.
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PPy coated PLCL/SF electrospun nanofibers significantly improve electrical conductivity of nerve ducts while ensuring good biocompatibility, and promote proliferation and differentiation of PC12 cells and Schwann cells and axon extension with exogenous electrical stimulation.
“Sun et al. wrapped PPy monomer into PLCL/SF electrospun nanofibers by in-situ oxidative polymerization, which significantly improved the electrical conductivity of nerve ducts while ensuring good biocompatibility, and promoted the proliferation and differentiation of PC12 cells and Schwann cells and axon extension on PPy coated nanofibers by applying exogenous electrical stimulation [188].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [188]
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- Authors
- Sun, B., Zhou, Z., Li, D., Wu, T., Zheng, H., Liu, J., Wang, G., Yu, Y., & Mo, X.
- Affiliations
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Yu, Yinxian
- Mo, Xiumei
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 94
- Pages
- 190-199
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2890358329
- Cited by
- 100
- References
- 27
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research Program of China (2016YFA0201702, 2016YFA0201700)
- National Natural Science Foundation of China (31470941, 31271035, 31370986)
- Shanghai Municipal Science and Technology Commission (15JC1490100, 15441905100)
- Sichuan University (sklpme2016-4-29)
- Fundamental Research Funds for the Central Universities (CUSF-DH-D-2017046, CUSF-DH-D-2017047)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- polypyrrole coating, nerve conduits, silk fibroin, electrospun nanofibers, peripheral nerve regeneration, sciatic nerve defect, myelination, Schwann cell proliferation, conductive biomaterials, rat model
- MeSH terms
- Animals, Fibroins, Male, Nerve Regeneration, Polyesters, Polymers, Pyrroles, Schwann Cells, Sciatic Nerve, Rats, Sprague-Dawley, Spectroscopy, Fourier Transform Infrared, Guided Tissue Regeneration, Photoelectron Spectroscopy, Nanofibers
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