The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide
Abstract
The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.
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“curcumin-containing nanoliposomes as well as other delivery systems have been designed and show to be very effective in reducing the Aβ fibrils formation (Taylor et al., 2011; Lazar et al., 2013; Mourtas et al., 2014; Shahbaz et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Taylor et al., 2011
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Metadata
- Authors
- Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., Ferla, B. L., Nicotra, F., Masserini, M., Antimisiaris, S. G., Gregori, M., & Allsop, D.
- Affiliations
- Lancaster University (GB)
- University of Patras (GR)
- University of Milano-Bicocca (IT)
- Corresponding author
- Allsop, David
- ORCID
- Venue
- Nanomedicine Nanotechnology Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 7
- Issue
- 5
- Pages
- 541-550
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2082371846
- Cited by
- 149
- References
- 46
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 17 · 2013: 9 · 2012: 10
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- Funders
- Seventh Framework Programme (212043)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- curcumin, nanoliposomes, amyloid-beta 42, peptide aggregation inhibition, Alzheimer's disease, phosphatidic acid, cardiolipin, GM1 ganglioside, click chemistry, fibril formation, oligomerization, lipid ligands, nanomedicine
- MeSH terms
- Alzheimer Disease, Cardiolipins, Curcumin, G(M1) Ganglioside, Humans, Ligands, Liposomes, Peptide Fragments, Phosphatidic Acids, Amyloid beta-Peptides, Nanoparticles
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