Multifunctional Nanoliposomes with Curcumin-Lipid Derivative and Brain Targeting Functionality with Potential Applications for Alzheimer Disease
Abstract
With the objective to formulate multifunctional nanosized liposomes to target amyloid deposits in Alzheimer Disease (AD) brains, a lipid-PEG-curcumin derivative was synthesized and characterized. Multifunctional liposomes incorporating the curcumin derivative and additionally decorated with a Blood Brain Barrier (BBB) transport mediator (anti-Transferin antibody) were prepared and characterized. The fluorescence intensity of curcumin derivative was found to increase notably when the curcumin moiety was in the form of a diisopropylethylamine (DIPEA) salt. Both curcumin-derivative liposomes and curcumin-derivative Anti-TrF liposomes showed a high affinity for the amyloid deposits, on post-mortem brains samples of AD patients. The ability of both liposomes to delay Aβ1-42 peptide aggregation was confirmed by Thioflavin assay. However, the decoration of the curcumin-derivative liposomes with the Anti-TrF improved significantly the intake by the BBB cellular model. Results verify that the attachment of an antibody on the curcumin-liposome surface does not block deposit staining or prevention of Aβ aggregation, while the presence of the curcumin-PEG-lipid conjugate does not reduce their brain-targeting capability substantially, proving the potential of such multifunctional NLs for application in Alzheimer disease treatment and diagnosis.
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Curcumin-containing nanoliposomes and other delivery systems are very effective in reducing Aβ fibrils formation.
“curcumin-containing nanoliposomes as well as other delivery systems have been designed and show to be very effective in reducing the Aβ fibrils formation (Taylor et al., 2011; Lazar et al., 2013; Mourtas et al., 2014; Shahbaz et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Mourtas et al., 2014
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- Authors
- Mourtas, S., Lazar, A. N., Markoutsa, E., Duyckaerts, C., & Antimisiaris, S. G.
- Affiliations
- University of Patras (GR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Antimisiaris, Sophia G.
- Venue
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 80
- Pages
- 175-183
- ISSN
- 0223-5234 (ISSN-L)
- OpenAlex
- W2055937873
- Cited by
- 263
- References
- 36
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 21 · 2023: 25 · 2022: 27 · 2021: 31 · 2020: 28 · 2019: 23 · 2018: 21 · 2017: 9 · 2016: 11 · 2015: 21 · 2014: 5
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nanoliposomes, curcumin derivatives, PEG-lipid conjugates, blood-brain barrier targeting, amyloid deposits, Alzheimer's disease, amyloid-beta aggregation, fluorescence imaging, postmortem brain
- MeSH terms
- Alzheimer Disease, Biological Transport, Blood-Brain Barrier, Brain, Curcumin, Humans, Liposomes, Peptide Fragments, Polyethylene Glycols, Amyloid beta-Peptides, Protein Structure, Secondary, Nanoparticles, Protein Multimerization, Molecular Targeted Therapy
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