Curcumin-conjugated Nanoliposomes with High Affinity for Aβ Deposits: Possible Applications to Alzheimer Disease
Abstract
Accumulation of amyloid peptide (Aβ) in senile plaques is a hallmark lesion of Alzheimer disease (AD). The design of molecules able to target the amyloid pathology in tissue is receiving increasing attention, both for diagnostic and for therapeutic purposes. Curcumin is a fluorescent molecule with high affinity for the Aβ peptide but its low solubility limits its clinical use. Curcumin-conjugated nanoliposomes, with curcumin exposed at the surface, were designed. They appeared to be monodisperse and stable. They were non-toxic in vitro, down-regulated the secretion of amyloid peptide and partially prevented Aβ-induced toxicity. They strongly labeled Aβ deposits in post-mortem brain tissue of AD patients and APPxPS1 mice. Injection in the hippocampus and in the neocortex of these mice showed that curcumin-conjugated nanoliposomes were able to specifically stain the Aβ deposits in vivo. Curcumin-conjugated nanoliposomes could find application in the diagnosis and targeted drug delivery in AD.From the clinical editor In this preclinical study, curcumin-conjugated nanoliposomes were investigated as possible diagnostics and targeted drug delivery system in Alzheimer's disease, demonstrating strong labeling of Aβ deposits both in human tissue and in mice, and in vitro downregulation of amyloid peptide secretion and prevention of Aβ-induced toxicity.
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Curcumin-containing nanoliposomes and other delivery systems are very effective in reducing Aβ fibrils formation.
“curcumin-containing nanoliposomes as well as other delivery systems have been designed and show to be very effective in reducing the Aβ fibrils formation (Taylor et al., 2011; Lazar et al., 2013; Mourtas et al., 2014; Shahbaz et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Lazar et al., 2013
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- Authors
- Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., Antimisiaris, S. G., & Duyckaerts, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Patras (GR)
- Inserm (FR)
- Pitié-Salpêtrière Hospital (FR)
- Corresponding author
- Duyckaerts, Charles
- ORCID
- Venue
- Nanomedicine Nanotechnology Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 9
- Issue
- 5
- Pages
- 712-721
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2057031120
- Cited by
- 149
- References
- 41
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 14 · 2020: 13 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 2
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- curcumin, nanoliposomes, amyloid-beta, Alzheimer's disease, amyloid plaques, targeted drug delivery, amyloid-beta secretion, amyloid-beta toxicity, fluorescence imaging, hippocampus, neocortex, curcumin solubility
- MeSH terms
- Alzheimer Disease, Animals, Autopsy, Curcumin, Coloring Agents, Humans, Liposomes, Peptide Fragments, Amyloid beta-Peptides, Neocortex, Mice, Nanoparticles
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