Magnetic nanoparticle-based drug delivery for cancer therapy
Abstract
Nanoparticles have belonged to various fields of biomedical research for quite some time. A promising site-directed application in the field of nanomedicine is drug targeting using magnetic nanoparticles which are directed at the target tissue by means of an external magnetic field. Materials most commonly used for magnetic drug delivery contain metal or metal oxide nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs consist of an iron oxide core, often coated with organic materials such as fatty acids, polysaccharides or polymers to improve colloidal stability and to prevent separation into particles and carrier medium [1]. In general, magnetite and maghemite particles are those most commonly used in medicine and are, as a rule, well-tolerated. The magnetic properties of SPIONs allow the remote control of their accumulation by means of an external magnetic field. Conjugation of SPIONs with drugs, in combination with an external magnetic field to target the nanoparticles (so-called "magnetic drug targeting", MDT), has additionally emerged as a promising strategy of drug delivery. Magnetic nanoparticle-based drug delivery is a sophisticated overall concept and a multitude of magnetic delivery vehicles have been developed. Targeting mechanism-exploiting, tumor-specific attributes are becoming more and more sophisticated. The same is true for controlled-release strategies for the diseased site. As it is nearly impossible to record every magnetic nanoparticle system developed so far, this review summarizes interesting approaches which have recently emerged in the field of targeted drug delivery for cancer therapy based on magnetic nanoparticles.
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Among different inorganic nanomaterials, MNPs have been widely employed for tumor targeting.
“Among different inorganic nanomaterials, MNPs have been widely employed for tumor targeting.190”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [190]
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- Authors
- Tietze, R., Zaloga, J., Unterweger, H., Lyer, S., Friedrich, R. P., Janko, C., Pöttler, M., Dürr, S., & Alexiou, C.
- Affiliations
- Universitätsklinikum Erlangen (DE)
- Corresponding author
- Tietze, Rainer
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 468
- Issue
- 3
- Pages
- 463-470
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1173549266
- Cited by
- 425
- References
- 69
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 30 · 2023: 39 · 2022: 43 · 2021: 58 · 2020: 63 · 2019: 56 · 2018: 43 · 2017: 34 · 2016: 24 · 2015: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- DFG (AL 552/5-1)
- Cluster of Excellence Engineering of Advanced Materials (EAM)
- Margarete Ammon Stiftung
- Bavarian State Ministry of the Environment and Consumer Protection (74a-U8793-2012/7–35)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
- Keywords
- magnetic nanoparticles, superparamagnetic iron oxide nanoparticles, magnetic drug delivery, targeted drug delivery, cancer therapy, external magnetic field, magnetite, maghemite, nanoparticle coating, controlled release, tumor targeting
- MeSH terms
- Animals, Antineoplastic Agents, Delayed-Action Preparations, Humans, Neoplasms, Nanocapsules, Magnetite Nanoparticles, Magnetic Fields
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