The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer
Abstract
Exosomes have emerged as a promising drug carrier with low immunogenicity, high biocompatibility and delivery efficiency. Here in, we isolated exosomes from A33-positive LIM1215 cells (A33-Exo) and loaded them with doxorubicin (Dox). Furthermore, we coated surface-carboxyl superparamagnetic iron oxide nanoparticles (US) with A33 antibodies (A33Ab-US), expecting that these A33 antibodies on the surface of the nanoparticles could bind to A33-positive exosomes and form a complex (A33Ab-US-Exo/Dox) to target A33-positive colon cancer cells. The results showed that A33Ab-US-Exo/Dox had good binding affinity and antiproliferative effect in LIM1215 cells, as shown by increased uptake of the complex. In vivo study showed that A33Ab-US-Exo/Dox had an excellent tumor targeting ability, and was able to inhibit tumor growth and prolong the survival of the mice with reduced cardiotoxicity. In summary, exosomes functionalized by targeting ligands through coating with high-density antibodies may prove to be a novel delivery system for targeted drugs against human cancers.
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Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
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Cited by
Biodistribution of extracellular vesicles following administration into animals: A systematic review
Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. W. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 485
Exosome engineering: Current progress in cargo loading and targeted delivery
Fu, S., Wang, Y., Xia, X., & Zheng, J. C. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100261 · Cited by 444
Engineered Extracellular Vesicles for Cancer Therapy
Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428
Extracellular vesicles: A bright star of nanomedicine
Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368
Exosome engineering in cell therapy and drug delivery
Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351
Metadata
- Authors
- Li, Y., Gao, Y., Gong, C., Wang, Z., Xia, Q., Gu, F., Hu, C., Zhang, L., Guo, H., & Gao, S.
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 14
- Issue
- 7
- Pages
- 1973-1985
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2809674729
- Cited by
- 222
- References
- 4
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y., Gao, Y., Gong, C., Wang, Z., Xia, Q., Gu, F., Hu, C., Zhang, L., Guo, H., & Gao, S. (2018). A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2018.05.020
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