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Cited by 506

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation

Open access
Talelli, Marina, Barz, Matthias, Rijcken, Cristianne J.F., Kiessling, Fabian, Hennink, Wim E., Lammers, Twan·2015·Nano Today
DOI 10.1016/j.nantod.2015.01.005
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Abstract

Polymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs. Many different PM have been designed and evaluated over the years, and some of them have steadily progressed through clinical trials. Increasing evidence suggests, however, that for prolonged circulation times and for efficient EPR-mediated drug targeting to tumors and to sites of inflammation, PM need to be stabilized, to prevent premature disintegration. Core-crosslinking is among the most popular methods to improve the in vivo stability of PM, and a number of core-crosslinked polymeric micelles (CCPM) have demonstrated promising efficacy in animal models. The latter is particularly true for CCPM in which (pro−) drugs are covalently entrapped. This ensures proper drug retention in the micelles during systemic circulation, efficient drug delivery to pathological sites via EPR, and tailorable drug release kinetics at the target site. We here summarize recent advances in the CCPM field, addressing the chemistry involved in preparing them, their in vitro and in vivo performance, potential biomedical applications, and guidelines for efficient clinical translation.

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Metadata

Authors
Talelli, M., Barz, M., Rijcken, C. J. F., Kiessling, F., Hennink, W. E., & Lammers, T.
Venue
Nano Today
Publisher
Elsevier BV
Published
2015-02
Volume
10
Issue
1
Pages
93-117
ISSN
1748-0132 (ISSN-L)
DOI
10.1016/j.nantod.2015.01.005
OpenAlex
W2072931565
Cited by
506
References
24
FWCI
19.47
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation. https://app.cochat.ai/papers/10.1016/j.nantod.2015.01.005
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Talelli, M., Barz, M., Rijcken, C. J. F., Kiessling, F., Hennink, W. E., & Lammers, T. (2015). Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation. Nano Today. https://doi.org/10.1016/j.nantod.2015.01.005

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.