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Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition
Open accessAbstract
Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing beta-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid beta (Abeta) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI.
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“The effects of amyloid plaques, the other hallmark pathology of AD, have been investigated in previous studies (Song et al., 2004, Sun et al., 2005) where differences in DTI parameters have been observed at late time points after the appearance of amyloid plaques.”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Song et al., 2004
In the citing paper
“These observations raise the prospect that degeneration could be initiated through synaptic or axonal mechanisms, independent of apoptosis, a mechanism which has been widely studied in other model systems, such as spinal cord injury and Multiple Sclerosis 59–61.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [59]
In the citing paper
“Our dMRI results are generally consistent with those reported using other mouse models of AD [31–35].”
From Brain microstructure abnormalities in the 3xTg-AD mouse – A diffusion MRI and morphology correlation study (2022) · cites this paper as [31]
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Self-citation
Metadata
- Authors
- Song, S.-K., Kim, J. H., Lin, S.-J., Brendza, R. P., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Song, Sheng-Kwei
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 15
- Issue
- 3
- Pages
- 640-647
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W1969674465
- Cited by
- 170
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 15 · 2012: 8
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eli Lilly and Company
- National Institute on Aging (AG11355, AG 05681, P 50 AG05681, P50AG005681, AG13956, P01AG011355)
- National Cancer Institute (R24CA083060, 1 R24 CA83060-01)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, white matter injury, amyloid-beta deposition, PDAPP mice, age-related neurodegeneration, diffusion tensor imaging, transgenic mouse model
- MeSH terms
- Aging, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Transgenic, Platelet-Derived Growth Factor, Promoter Regions, Genetic, Amyloid beta-Protein Precursor, Diffusion Magnetic Resonance Imaging, Mice, Plaque, Amyloid
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