Cited by 170Advanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

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Song, Sheng-Kwei, Kim, Joong Hee, Lin, Shiow-Jiuan, Brendza, Robert P., Holtzman, David M.·2004·Neurobiology of Disease

DOI 10.1016/j.nbd.2003.12.003

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Abstract

Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing beta-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid beta (Abeta) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI.

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Authors: Song, S.-K., Kim, J. H., Lin, S.-J., Brendza, R. P., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Song, Sheng-Kwei
ORCID: Song, Sheng-Kwei
Holtzman, David M.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2004-04
Volume: 15
Issue: 3
Pages: 640-647
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2003.12.003
OpenAlex: W1969674465
Cited by: 170
References: 52
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 15 · 2012: 8
FWCI: 7.82
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Eli Lilly and Company
National Institute on Aging (AG11355, AG 05681, P 50 AG05681, P50AG005681, AG13956, P01AG011355)
National Cancer Institute (R24CA083060, 1 R24 CA83060-01)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, white matter injury, amyloid-beta deposition, PDAPP mice, age-related neurodegeneration, diffusion tensor imaging, transgenic mouse model
MeSH terms: Aging, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Transgenic, Platelet-Derived Growth Factor, Promoter Regions, Genetic, Amyloid beta-Protein Precursor, Diffusion Magnetic Resonance Imaging, Mice, Plaque, Amyloid

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Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

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