Mild cognitive impairment and Alzheimer disease: regional diffusivity of water
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PURPOSE: To compare the regional diffusivity of water in the brains of normally aging elderly people and patients with mild cognitive impairment (MCI) or Alzheimer disease. MATERIALS AND METHODS: Magnetic resonance images were obtained in 21 patients with Alzheimer disease, 19 patients with MCI, and 55 normally aging elderly control subjects without evidence of cognitive impairment. Regions of interest were drawn to compare the apparent diffusion coefficient (ADC) and the anisotropy index (AI) in frontal, parietal, temporal, occipital, anterior, and posterior cingulate white matter (WM), and the thalami and hippocampi. RESULTS: Hippocampal ADC was higher in MCI and Alzheimer disease patients than in control subjects. ADC of the temporal stem and posterior cingulate, occipital, and parietal WM was higher in Alzheimer disease patients than in control subjects. Except for occipital AI, which was lower in MCI patients than in control subjects, there were no differences in AI among the three groups for any of the regions. CONCLUSION: Hippocampal ADC was significantly different between control subjects and MCI patients, many of whom likely have preclinical Alzheimer disease. Elevation in hippocampal ADC may reflect early ultrastructural changes in the progression of Alzheimer disease.
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The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients and in mouse models exhibiting amyloid pathology at late stages of progression.
“The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients (Fellgiebel et al., 2004, Kantarci et al., 2001, Rose et al., 2008) and in mouse models exhibiting amyloid pathology at late stages of progression (Sun et al., 2005).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Kantarci et al., 2001
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- Authors
- Kantarci, K., Jack, C. R., Xu, Y. C., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., & Petersen, R. C.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Radiology
- Published
- 2001-04
- Volume
- 219
- Issue
- 1
- Pages
- 101-107
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- PMC
- PMC2771587
- OpenAlex
- W2128776571
- Cited by
- 300
- References
- 36
- Citations by year
- 2026: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 22 · 2012: 9
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- mild cognitive impairment, Alzheimer's disease, apparent diffusion coefficient, anisotropy index, water diffusion, white matter, hippocampus, posterior cingulate cortex, preclinical Alzheimer's disease, brain aging, ultrastructural changes
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Brain, Cerebral Cortex, Diffusion, Female, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reference Values, Sensitivity and Specificity, Thalamus, Anisotropy
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