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Cited by 517Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

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Edison, Paul, Archer, Hilary A., Gerhard, Alexander, Hinz, Rainer, Pavese, Nicola, Turkheimer, Federico E., Hammers, Alexander, Tai, Yen Fong, Fox, Nick, Kennedy, Angus, Rossor, Martin, Brooks, David J.·2008·Neurobiology of Disease
DOI 10.1016/j.nbd.2008.08.001
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Abstract

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p<0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p<0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage.

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Metadata

Authors
Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., Rossor, M., & Brooks, D. J.
Affiliations
  • Hammersmith Hospital (GB)
  • University of Manchester (GB)
Corresponding author
Edison, Paul
ORCID
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2008-12
Volume
32
Issue
3
Pages
412-419
ISSN
0969-9961 (ISSN-L)
DOI
10.1016/j.nbd.2008.08.001
OpenAlex
W1993305977
Cited by
513
References
55
Citations by year
2026: 9 · 2025: 19 · 2024: 21 · 2023: 16 · 2022: 27 · 2021: 40 · 2020: 29 · 2019: 32 · 2018: 27 · 2017: 44 · 2016: 39 · 2015: 40 · 2014: 46 · 2013: 33 · 2012: 31
FWCI
12.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, microglial activation, amyloid-beta, cognitive impairment, [11C](R)-PK11195, [11C]PIB, positron emission tomography, association cortex, Mini-Mental State Examination, neuroinflammation, neuronal injury
MeSH terms
Aged, Alzheimer Disease, Amyloid, Aniline Compounds, Carbon Radioisotopes, Cerebral Cortex, Cognition, Female, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Thiazoles, Cluster Analysis, Microglia, Positron-Emission Tomography

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