In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease
Open accessAbstract
Purpose Amyloid β protein (Aβ) is known as a pathological substance in Alzheimer's disease (AD) and is assumed to coexist with a degree of activated microglia in the brain. However, it remains unclear whether these two events occur in parallel with characteristic hypometabolism in AD in vivo. The purpose of the present study was to clarify the in vivo relationship between Aβ accumulation and neuroinflammation in those specific brain regions in early AD.Methods Eleven nootropic drug-naïve AD patients underwent a series of positron emission tomography (PET) measurements with [(11)C](R)PK11195, [(11)C]PIB and [(18)F]FDG and a battery of cognitive tests within the same day. The binding potentials (BPs) of [(11)C](R)PK11195 were directly compared with those of [(11)C]PIB in the brain regions with reduced glucose metabolism.Results BPs of [(11)C](R)PK11195 and [(11)C]PIB were significantly higher in the parietotemporal regions of AD patients than in ten healthy controls. In AD patients, there was a negative correlation between dementia score and [(11)C](R)PK11195 BPs, but not [(11)C]PIB, in the limbic, precuneus and prefrontal regions. Direct comparisons showed a significant negative correlation between [(11)C](R)PK11195 and [(11)C]PIB BPs in the posterior cingulate cortex (PCC) (p < 0.05, corrected) that manifested the most severe reduction in [(18)F]FDG uptake.Conclusion A lack of coupling between microglial activation and amyloid deposits may indicate that Aβ accumulation shown by [(11)C]PIB is not always the primary cause of microglial activation, but rather the negative correlation present in the PCC suggests that microglia can show higher activation during the production of Aβ in early AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AD patients show significantly increased regional TSPO ligand binding in the cortices compared to controls using TSPO-specific radiotracers.
“AD patients all showed significantly increased regional TSPO ligand binding in the cortices compared to controls.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works
Simplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025 · see citing works
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works
Jack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099 · see citing works
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works
Microglial activation and dopamine terminal loss in early Parkinson's disease
Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., & Torizuka, T. (2005) · Annals of Neurology · doi:10.1002/ana.20338 · Cited by 846 · see citing works
Self-citationKinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., Holt, D. P., MELTZER, C. C., DeKosky, S. T., & Mathis, C. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600146 · Cited by 712 · see citing works
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
Jacobsen, J. S., Wu, C.-C., Redwine, J. M., Comery, T. A., Arias, R., Bowlby, M., Martone, R., Morrison, J. H., Pangalos, M. N., Reinhart, P. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600948103 · Cited by 701 · see citing works
The peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661 · see citing works
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
Barger, S. W., & Harmon, A. D. (1997) · Nature · doi:10.1038/42257 · Cited by 622 · see citing works
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
Engler, H., Forsberg, A., Almkvist, O., Blomquist, G., Larsson, E., Savitcheva, I., Wall, A. E., Ringheim, A., Långström, B., & Nordberg, A. K. (2006) · Brain · doi:10.1093/brain/awl178 · Cited by 614 · see citing works
Lopresti, B. J., Klunk, W. E., Mathis, C. A., Hoge, J. A., Ziolko, S. K., Lu, X., MELTZER, C. C., Schimmel, K., Tsopelas, N. D., DeKosky, S. T., et al. (2005) · PubMed · Cited by 536 · see citing works
Alexander, G. E., Chen, K., Pietrini, P., Rapoport, S. I., & Reiman, E. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.738 · Cited by 532 · see citing works
Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study
Edison, P., Archer, H. A., Hinz, R., Hammers, A., Pavese, N., Tai, Y. F., Hotton, G., Cutler, D., Fox, N., Kennedy, A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000244749.20056.d4 · Cited by 518 · see citing works
Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.001 · Cited by 513 · see citing works
Role of toll-like receptor signalling in A uptake and clearance
Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works
Anti-inflammatory drugs and Alzheimer disease
McGeer, P. L., McGeer, E. G., Rogers, J., & Sibley, J. T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91101-f · Cited by 437 · see citing works
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 352 · see citing works
Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-22 · Cited by 309 · see citing works
Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
Self-citationRichard, K. L., Filali, M., Préfontaine, P., & Rivest, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1146-08.2008 · Cited by 261 · see citing works
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R. A., & Mullan, M. J. (2002) · Nature Neuroscience · doi:10.1038/nn968 · Cited by 217 · see citing works
Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214 · see citing works
Malaplate, C., Florent‐Béchard, S., Youssef, I., Koziel, V., Sponne, I., Kriem, B., Leininger‐Muller, B., Olivier, J. L., Oster, T., & Pillot, T. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.010 · Cited by 213 · see citing works
Drzezga, A. E., Grimmer, T., Henriksen, G., Stangier, I., Perneczky, R., Diehl‐Schmid, J., Mathis, C. A., Klunk, W. E., Price, J. C., & DeKosky, S. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.020 · Cited by 202 · see citing works
Leinonen, V. (2008) · Archives of Neurology · doi:10.1001/archneur.65.10.noc80013 · Cited by 199 · see citing works
Wiley, C. A., Lopresti, B. J., Venneti, S., Price, J. C., Klunk, W. E., DeKosky, S. T., & Mathis, C. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.511 · Cited by 160 · see citing works
Ouchi, Y., Yoshikawa, E., Okada, H., Futatsubashi, M., Sekine, Y., Iyo, M., & Sakamoto, M. (1999) · PubMed · Cited by 145 · see citing works
Self-citationFollow-up of [ 11 C]PIB uptake and brain volume in patients with Alzheimer disease and controls
Scheinin, N. M., Aalto, S., Koikkalainen, J. R., Lötjönen, J. M. P., Karrasch, M., Kemppainen, N. M., Viitanen, M. H., Någren, K., Helin, S., Scheinin, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bacf1b · Cited by 128 · see citing works
Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo
Craft, J. M., Watterson, D. M., Frautschy, S. A., & Eldik, L. J. V. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.006 · Cited by 91 · see citing works
Szczepanik, A. M., Rampe, D., & Ringheim, G. E. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00240.x · Cited by 87 · see citing works
Altered glucose metabolism in the hippocampal head in memory impairment
Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., & Kaneko, M. (1998) · Neurology · doi:10.1212/wnl.51.1.136 · Cited by 85 · see citing works
Self-citationAccuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine
Rosi, S., Ramı́rez-Amaya, V., Vazdarjanova, A. I., Esparza, E. E., Larkin, P. B., Fike, J. R., Wenk, G. L., & Barnes, C. A. (2009) · Brain · doi:10.1093/brain/awp148 · Cited by 76 · see citing works
A new high-resolution PET scanner dedicated to brain research
Watanabe, M., Shimizu, K., Omura, T., Takahashi, M., Kosugi, T., Yoshikawa, E., Sato, N., Okada, H., & Yamashita, T. (2002) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2002.1039541 · Cited by 61 · see citing works
Self-citationMackenzie, I. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00304-9 · Cited by 35 · see citing works
Foster, N. L., Wang, A. Y., Taşdizen, T., Fletcher, P. T., Hoffman, J. M., & Koeppe, R. A. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.10.004 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179 · see citing works
Neuroinflammation in Alzheimer's disease: current evidence and future directions
Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457 · see citing works
Docosahexaenoic Acid and Cognition throughout the Lifespan
Weiser, M., Butt, C., & Mohajeri, M. (2016) · Nutrients · doi:10.3390/nu8020099 · Cited by 400 · see citing works
Varnum, M. M., & Ikezu, T. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0181-2 · Cited by 393 · see citing works
Nakatomi, Y., Mizuno, K., Ishii, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131045 · Cited by 366 · see citing works
Review: Systemic inflammation and<scp>A</scp>lzheimer's disease
Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356 · see citing works
The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology
Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324 · see citing works
Wright, A. L., Zinn, R., Hohensinn, B., Konen, L. M., Beynon, S. B., Tan, R. P., Clark, I. A., Abdipranoto, A., & Vissel, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059586 · Cited by 310 · see citing works
Neuroinflammation in Neurodegenerative Disorders-a Review
Schain, M., & Kreisl, W. C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0733-2 · Cited by 301 · see citing works
Neuroinflammation in Alzheimer’s Disease
Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works
Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293 · see citing works
Neuroimaging biomarkers for Alzheimer’s disease.
Márquez, F., & Yassa, M. A. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0325-5 · Cited by 289 · see citing works
Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis
Bradburn, S., Murgatroyd, C., & Ray, N. J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.002 · Cited by 268 · see citing works
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 266 · see citing works
PET Imaging of Neuroinflammation in Neurological Disorders
Kreisl, W., Kim, M.-J., Coughlin, J. M., Henter, I., Owen, D. R., & Innis, R. (2020) · Lancet Neurology · doi:10.1016/s1474-4422(20)30346-x · Cited by 180 · see citing works
Noninvasive Molecular Imaging of Neuroinflammation
Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245 · see citing works
Targeting Neuroinflammation to Treat Alzheimer’s Disease
Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 236 · see citing works
Narayanaswami, V., Dahl, K., Bernard‐Gauthier, V., Josephson, L., Cumming, P. D., & Vasdev, N. (2018) · Molecular Imaging · doi:10.1177/1536012118792317 · Cited by 215 · see citing works
Fan, Z., Aman, Y., Ahmed, I., Chetelat, G., Landeau, B., Ray Chaudhuri, K., Brooks, D. J., & Edison, P. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.016 · Cited by 212 · see citing works
PET Imaging of Inflammation Biomarkers
Wu, C., Li, F., Niu, G., & Chen, X. S. (2013) · Theranostics · doi:10.7150/thno.6592 · Cited by 199 · see citing works
Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease
Malpetti, M., Kievit, R. A., Passamonti, L., Jones, P. S., Tsvetanov, K. A., Rittman, T., Mak, E., Nicastro, N., Bevan-Jones, W. R., Su, L., et al. (2020) · Brain · doi:10.1093/brain/awaa088 · Cited by 194 · see citing works
Chandra, A., Valkimadi, P., Pagano, G., Cousins, O., Dervenoulas, G., Politis, M., & Initiative, A. D. N. (2019) · Human Brain Mapping · doi:10.1002/hbm.24782 · Cited by 187 · see citing works
Dupont, A.-C., Largeau, B., Santiago Ribeiro, M., Guilloteau, D., Tronel, C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040785 · Cited by 182 · see citing works
Hamelin, L., Lagarde, J., Dorothée, G., Potier, M. C., Corlier, F., Kuhnast, B., Caillé, F., Dubois, B., Fillon, L., Chupin, M., et al. (2018) · Brain · doi:10.1093/brain/awy079 · Cited by 177 · see citing works
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
Schuitemaker, A., Kropholler, M. A., Boellaard, R., van der Flier, W. M., Kloet, R. W., van der Doef, T. F., Knol, D. L., Windhorst, A. D., Luurtsema, G., Barkhof, F., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.021 · Cited by 167 · see citing works
Cistaro, A., Valentini, M. C., Chiò, A., Nobili, F. M., Calvo, A., Moglia, C., Montuschi, A., Morbelli, S. D., Salmaso, D., Fania, P., et al. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1979-6 · Cited by 173 · see citing works
Zeineh, M. M., Chen, Y., Kitzler, H. H., Hammond, R., Vogel, H., & Rutt, B. K. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.022 · Cited by 151 · see citing works
PET Imaging of Neuroinflammation in Alzheimer’s Disease
Zhou, R., Ji, B., Kong, Y., Qin, L., Ren, W., Guan, Y., & Ni, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739130 · Cited by 150 · see citing works
Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Nozaki, S., Takahashi, S., Mizukami, K., Asada, T., et al. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.08.013 · Cited by 148 · see citing works
Fan, Z., Okello, A. A., Brooks, D. J., & Edison, P. (2015) · Brain · doi:10.1093/brain/awv288 · Cited by 135 · see citing works
Suridjan, I., Pollock, B. G., Verhoeff, N. P. L. G., Voineskos, A. N., Chow, T., Rusjan, P. M., Lobaugh, N. J., Houle, S., Mulsant, B. H., & Mizrahi, R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.1 · Cited by 132 · see citing works
Golla, S. S. V., Boellaard, R., Oikonen, V., Hoffmann, A., van Berckel, B. N. M., Windhorst, A. D., Virta, J. R., Haaparanta‐Solin, M., Luoto, P., Savisto, N., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.261 · Cited by 128 · see citing works
Targeting innate immunity for neurodegenerative disorders of the central nervous system
Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works
Terada, T., Yokokura, M., Yoshikawa, E., Futatsubashi, M., Kono, S., Konishi, T., Miyajima, H., Hashizume, T., & Ouchi, Y. (2016) · Annals of Nuclear Medicine · doi:10.1007/s12149-016-1099-2 · Cited by 124 · see citing works
Self-citationFard, M. T., & Stough, C. K. K. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00056 · Cited by 121 · see citing works
In vivo molecular imaging of neuroinflammation in Alzheimer's disease
Chaney, A. M., Williams, S. R., & Boutin, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14615 · Cited by 116 · see citing works
Imaging of microglia in patients with neurodegenerative disorders
Politis, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00096 · Cited by 111 · see citing works
PET Neuroimaging of Alzheimer's Disease: Radiotracers and Their Utility in Clinical Research
Bao, W., Xie, F., Zuo, C., Guan, Y., & Huang, Y. H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.624330 · Cited by 102 · see citing works
Imaging of neuroinflammation in dementia: a review
Stefaniak, J. D., & O'Brien, J. T. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311336 · Cited by 109 · see citing works
Tondo, G., Iaccarino, L., Caminiti, S. P., Presotto, L., Santangelo, R., Iannaccone, S., Magnani, G., & Perani, D. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00619-0 · Cited by 107 · see citing works
In Vivo Mitochondrial and Glycolytic Impairments in Patients with Alzheimer Disease
Terada, T., Obi, T., Bunai, T., Matsudaira, T., Yoshikawa, E., Ando, I., Futatsubashi, M., Tsukada, H., & Ouchi, Y. (2020) · Neurology · doi:10.1212/wnl.0000000000009249 · Cited by 103 · see citing works
Self-citationInnate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases
Novellino, F., Saccà, V., Donato, A., Zaffino, P., Spadea, M. F., Vismara, M. F. M., Arcidiacono, B., Malara, N., Presta, I., & Donato, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031115 · Cited by 104 · see citing works
Wu, X. G., Lv, Y., Du, Y., Chen, F., Reed, M. N., Hu, M. Y., Suppiramaniam, V. D., Tang, S., & Hong, H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.018 · Cited by 100 · see citing works
Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment
Knezevic, D., & Mizrahi, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.007 · Cited by 97 · see citing works
Inflammasome-mediated innate immunity in Alzheimer’s disease
Venegas, C., & Heneka, M. T. (2019) · The FASEB Journal · doi:10.1096/fj.201900439 · Cited by 93 · see citing works
Frings, L., Hellwig, S., Spehl, T. S., Bormann, T., Buchert, R., Vach, W., Minkova, L., Heimbach, B., Klöppel, S., & Meyer, P. T. (2015) · Brain · doi:10.1093/brain/awv229 · Cited by 90 · see citing works
Patir, A., Shih, B., McColl, B. W., & Freeman, T. C. (2019) · Glia · doi:10.1002/glia.23572 · Cited by 90 · see citing works
Best, L. A., Ghadery, C., Pavese, N., Tai, Y., & Strafella, A. P. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0934-y · Cited by 89 · see citing works
Owen, D. R., & Matthews, P. M. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00002-x · Cited by 88 · see citing works
In vivo Imaging of Glial Activation in Alzheimer's Disease
Edison, P., Donat, C. K., & Sastre, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00625 · Cited by 86 · see citing works
Yokokura, M., Terada, T., Bunai, T., Nakaizumi, K., Takebayashi, K., Iwata, Y., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Mori, N., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16646788 · Cited by 85 · see citing works
Self-citationMirzaei, N., Tang, S. P., Ashworth, S., Coello, C., Plisson, C., Passchier, J., Selvaraj, V., Tyacke, R. J., Nutt, D. J., & Sastre, M. (2016) · Glia · doi:10.1002/glia.22978 · Cited by 82 · see citing works
Cerami, C., Iaccarino, L., & Perani, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050993 · Cited by 75 · see citing works
Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer’s aetiopathology
Okada, H., Ouchi, Y., Ogawa, M., Futatsubashi, M., Saito, Y., Yoshikawa, E., Terada, T., Oboshi, Y., Tsukada, H., Ueki, T., et al. (2013) · Brain · doi:10.1093/brain/awt195 · Cited by 72 · see citing works
Self-citationIn vivo PET imaging of neuroinflammation in Alzheimer’s disease
Lagarde, J., Sarazin, M., & Bottlaender, M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1731-x · Cited by 70 · see citing works
Imaging and Molecular Mechanisms of Alzheimer’s Disease: A Review
Femminella, G. D., Thayanandan, T., Calsolaro, V., Komici, K., Rengo, G., Corbi, G., & Ferrara, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123702 · Cited by 68 · see citing works
Yokokura, M., Takebasashi, K., Takao, A., Nakaizumi, K., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Nakamura, K., Yamasue, H., & Ouchi, Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0784-7 · Cited by 66 · see citing works
Self-citationCavedo, E., Lista, S., Khachaturian, Z., Aisen, P., Amouyel, P., Herholz, K., Jack Jr, C. R., Sperling, R., Cummings, J., Blennow, K., et al. (2014) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2014.32 · Cited by 67 · see citing works
Gereñu, G., Liu, K., Chojnacki, J. E., Saathoff, J. M., Martínez‐Martín, P., Perry, G. L., Zhu, X., Lee, H., & Zhang, S. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00082 · Cited by 67 · see citing works
Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.010 · Cited by 67 · see citing works
Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update
Gouilly, D., Saint‐Aubert, L., Ribeiro, M. J., Salabert, A., Tauber, C., Péran, P., Arlicot, N., Pariente, J., & Payoux, P. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15613 · Cited by 66 · see citing works
Edison, P., & Brooks, D. J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179929 · Cited by 62 · see citing works
In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer’s disease
Terada, T., Yokokura, M., Obi, T., Bunai, T., Yoshikawa, E., Ando, I., Shimada, H., Suhara, T., Higuchi, M., & Ouchi, Y. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09400-2 · Cited by 60 · see citing works
Self-citationMicroglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia
Malpetti, M., Cope, T., Street, D., Jones, P. S., Hezemans, F. H., Mak, E., Tsvetanov, K. A., Rittman, T., Bevan-Jones, W. R., Patterson, K. E., et al. (2023) · Brain · doi:10.1093/brain/awad078 · Cited by 58 · see citing works
Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
Faculty, O. B. O. T. M., Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04462-w · Cited by 55 · see citing works
PET Imaging for Early Detection of Alzheimer’s Disease
Bao, W., Jia, H., Finnema, S. J., Cai, Z., Carson, R. E., & Huang, Y. H. (2017) · PET Clinics · doi:10.1016/j.cpet.2017.03.001 · Cited by 54 · see citing works
The emerging role of PET imaging in dementia
Iaccarino, L., Sala, A., Caminiti, S. P., & Perani, D. (2017) · F1000Research · doi:10.12688/f1000research.11603.1 · Cited by 51 · see citing works
Molecular Imaging Approaches in Dementia.
Villemagne, V., Barkhof, F., Garibotto, V., Landau, S., Nordberg, A., & van Berckel, B. N. (2021) · Radiology · doi:10.1148/radiol.2020200028 · Cited by 41 · see citing works
Neuroimaging biomarkers in Alzheimer’s disease and other dementias
Villemagne, V. L., & Chételat, G. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.004 · Cited by 48 · see citing works
Advances in Brain Amyloid Imaging
Krishnadas, N., Villemagne, V. L., Doré, V., & Rowe, C. C. (2021) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2020.12.005 · Cited by 48 · see citing works
Janssen, B., & Mach, R. H. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.04.005 · Cited by 45 · see citing works
Amandine, E. B., & Marchalant, Y. (2015) · Aging and Disease · doi:10.14336/ad.2015.0617 · Cited by 43 · see citing works
Immune-mediated processes in neurodegeneration: where do we stand?
Fakhoury, M. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8052-0 · Cited by 43 · see citing works
Cai, P., Li, W., Xu, Y., & Wang, H. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106561 · Cited by 42 · see citing works
Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia
Kreisl, W. C., Henter, I. D., & Innis, R. B. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.004 · Cited by 39 · see citing works
Wang, Q., Chen, G., Schindler, S. E., Christensen, J. J., McKay, N. S., Liu, J., Wang, S., Sun, Z., Hassenstab, J. J., Su, Y., et al. (2022) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001152 · Cited by 44 · see citing works
Biomarkers for Microglial Activation in Alzheimer′s Disease
Lautner, R., Mattsson, N., Schöll, M., Augutis, K., Blennow, K., Olsson, B., & Zetterberg, H. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/939426 · Cited by 36 · see citing works
Chaney, A. M., Bauer, M., Bochicchio, D., Smigova, A., Kassiou, M., Davies, K. E., Williams, S. R., & Boutin, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14251 · Cited by 37 · see citing works
In vivo Depiction of α7 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer’s Disease
Nakaizumi, K., Ouchi, Y., Terada, T., Yoshikawa, E., Kakimoto, A., Isobe, T., Bunai, T., Yokokura, M., Suzuki, K., & Magata, Y. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170591 · Cited by 35 · see citing works
Self-citationHosoya, T., Fukumoto, D., Kakiuchi, T., Nishiyama, S., Yamamoto, S., Ohba, H., Tsukada, H., Ueki, T., Sato, K., & Ouchi, Y. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0851-4 · Cited by 34 · see citing works
Self-citationIwahara, N., Hisahara, S., Kawamata, J., Matsumura, A., Yokokawa, K., Saito, T., Fujikura, M., Manabe, T., Suzuki, H., Matsushita, T., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160887 · Cited by 34 · see citing works
Küntzelmann, A., Guenther, T., Haberkorn, U., Essig, M., Giesel, F. L., Henze, R., Schroeter, M. L., Schröder, J., & Schönknecht, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.11.026 · Cited by 31 · see citing works
Use of Biomarkers in Clinical Trials of Alzheimer Disease
Wu, L., Rosa‐Neto, P., & Gauthier, S. G. (2011) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256467 · Cited by 31 · see citing works
Hommet, C., Mondon, K., Camus, V., Ribeiro, M. J., Beaufils, É., Arlicot, N., Corcia, P., Paccalin, M., Minier, F., Gosselin, T., et al. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000354363 · Cited by 30 · see citing works
Xu, A., Tang, Y., Zeng, Q., Wang, X., Tian, H., Zhou, Y., & Li, Z. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200242 · Cited by 30 · see citing works
Kikuchi, M., Hirosawa, T., Yokokura, M., Yagi, S., Mori, N., Yoshikawa, E., Yoshihara, Y., Sugihara, G., Takebayashi, K., Iwata, Y., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2535-11.2011 · Cited by 30 · see citing works
Self-citationJeong, Y. J., Yoon, H. J., & Kang, D. (2017) · Medicine · doi:10.1097/md.0000000000009042 · Cited by 29 · see citing works
Loftus, J. R., Puri, S., & Meyers, S. P. (2023) · Insights into Imaging · doi:10.1186/s13244-022-01358-6 · Cited by 28 · see citing works
New Molecular Targets for PET and SPECT Imaging in Neurodegenerative Diseases
Benadiba, M., Luurtsema, G., Wichert‐Ana, L., Buchpiguel, C. A., & Busatto, G. F. (2012) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.07.002 · Cited by 27 · see citing works
Parametric Binding Images of the TSPO Ligand 18F-DPA-714
Golla, S. S. V., Boellaard, R., Oikonen, V., Hoffmann, A., van Berckel, B. N. M., Windhorst, A. D., Virta, J. R., Beek, E. T. T., Groeneveld, G. J., Haaparanta‐Solin, M., et al. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.173013 · Cited by 27 · see citing works
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter
Glodzik, L., Kuceyeski, A. F., Rusinek, H., Tsui, W.-H., Mosconi, L., Li, Y., Osorio, R. S., Williams, S., Randall, C., Spector, N. C., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.060 · Cited by 26 · see citing works
Iaccarino, L., Moresco, R. M., Presotto, L., Bugiani, O., Iannaccone, S., Giaccone, G., Tagliavini, F., & Perani, D. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0522-6 · Cited by 26 · see citing works
Yamagishi, S., Iga, Y., Nakamura, M., Takizawa, C., Fukumoto, D., Kakiuchi, T., Nishiyama, S., Ohba, H., Tsukada, H., Sato, K., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1604-3 · Cited by 25 · see citing works
Self-citationPerani, D., Iaccarino, L., Lammertsma, A. A., Windhorst, A. D., Edison, P., Boellaard, R., Hansson, O., Nordberg, A. K., Jacobs, A. H., & IMBI Project (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.02.004 · Cited by 24 · see citing works
Ji, B., Ono, M., Yamasaki, T., Fujinaga, M., Zhang, M., Seki, C., Aoki, I., Kito, S., Sawada, M., Suhara, T., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21992457 · Cited by 25 · see citing works
Ayton, S., Janelidze, S., Kalinowski, P., Palmqvist, S., Belaidi, A. A., Stomrud, E., Roberts, A., Roberts, B. R., Hansson, O., & Bush, A. I. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-330052 · Cited by 24 · see citing works
Imaging multiple sclerosis and other neurodegenerative diseases
Inglese, M., & Petracca, M. (2013) · Prion · doi:10.4161/pri.22650 · Cited by 21 · see citing works
- Authors
- Yokokura, M., Mori, N., Yagi, S., Yoshikawa, E., Kikuchi, M., Yoshihara, Y., Wakuda, T., Sugihara, G., Takebayashi, K., Suda, S., Iwata, Y., Ueki, T., Tsuchiya, K. J., Suzuki, K., Nakamura, K., & Ouchi, Y.
- Affiliations
- Hamamatsu University School of Medicine (JP)
- Hamamatsu University (JP)
- Hamamatsu Photonics (Japan) (JP)
- Kanazawa University (JP)
- Corresponding author
- Ouchi, Yasuomi
- ORCID
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2010-09-16
- Volume
- 38
- Issue
- 2
- Pages
- 343-351
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- OpenAlex
- W1991282216
- Cited by
- 174
- References
- 42
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 12 · 2020: 13 · 2019: 18 · 2018: 11 · 2017: 17 · 2016: 14 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 10
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- HamaMed-Repository (Hamamatsu University School of Medicine) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (22591260, 23390287, 22591258, 23659562)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microglial activation, amyloid-beta, hypometabolism, neuroinflammation, PK11195, Pib, FDG-PET, posterior cingulate cortex, early Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Glucose, Humans, Male, Middle Aged, Neurons, Radioactive Tracers, Case-Control Studies, Amyloid beta-Peptides, Microglia, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review