The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
Open accessAbstract
Dysfunction of the microRNA (miR) network has been emerging as a major regulator in neurological diseases. However, little is known about the functional significance of unique miRs in ischemic brain damage. Here, we found that miR-497 is induced in mouse brain after transient middle cerebral artery occlusion (MCAO) and mouse N2A neuroblastoma (N2A) cells after Oxygen-Glucose-Deprivation (OGD). Loss-of-miR-497 function significantly suppresses OGD-induced N2A cell death, whereas gain-of-miR-497 function aggravates OGD-induced neuronal loss. Moreover, miR-497 directly binds to the predicted 3'-UTR target sites of bcl-2/-w genes. Furthermore, knockdown of cerebral miR-497 effectively enhances bcl-2/-w protein levels in the ischemic region, attenuates ischemic brain infarction, and improves neurological outcomes in mice after focal cerebral ischemia. Taken together, our data suggest that miR-497 promotes ischemic neuronal death by negatively regulating anti-apoptotic proteins, bcl-2 and bcl-w. We raise the possibility that this pathway may contribute to the pathogenesis of the ischemic brain injury in stroke.
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Cites
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Cited by
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Pathogenic mechanisms following ischemic stroke
Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 621
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MicroRNA-based therapeutics in central nervous system injuries
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Self-citationAn antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model
Selvamani, A., Sathyan, P., Miranda, R. C., & Sohrabji, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032662 · Cited by 217
Metadata
- Authors
- Yin, K.-J., Deng, Z., Huang, H., Hamblin, M., Xie, C., Zhang, J., & Chen, Y. E.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 38
- Issue
- 1
- Pages
- 17-26
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2014474485
- Cited by
- 291
- References
- 45
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Yin, K.-J., Deng, Z., Huang, H., Hamblin, M., Xie, C., Zhang, J., & Chen, Y. E. (2010). miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2009.12.021
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