An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model
Open accessAbstract
We previously showed that middle-aged female rats sustain a larger infarct following experimental stroke as compared to younger female rats, and paradoxically, estrogen treatment to the older group is neurotoxic. Plasma and brain insulin-like growth factor-1 (IGF-1) levels decrease with age. However, IGF-1 infusion following stroke, prevents estrogen neurotoxicity in middle-aged female rats. IGF1 is neuroprotective and well tolerated, but also has potentially undesirable side effects. We hypothesized that microRNAs (miRNAs) that target the IGF-1 signaling family for translation repression could be alternatively suppressed to promote IGF-1-like neuroprotection. Here, we report that two conserved IGF pathway regulatory microRNAs, Let7f and miR1, can be inhibited to mimic and even extend the neuroprotection afforded by IGF-1. Anti-mir1 treatment, as late as 4 hours following ischemia, significantly reduced cortical infarct volume in adult female rats, while anti-Let7 robustly reduced both cortical and striatal infarcts, and preserved sensorimotor function and interhemispheric neural integration. No neuroprotection was observed in animals treated with a brain specific miRNA unrelated to IGF-1 (anti-miR124). Remarkably, anti-Let7f was only effective in intact females but not males or ovariectomized females indicating that the gonadal steroid environment critically modifies miRNA action. Let7f is preferentially expressed in microglia in the ischemic hemisphere and confirmed in ex vivo cultures of microglia obtained from the cortex. While IGF-1 was undetectable in microglia harvested from the non-ischemic hemisphere, IGF-1 was expressed by microglia obtained from the ischemic cortex and was further elevated by anti-Let7f treatment. Collectively these data support a novel miRNA-based therapeutic strategy for neuroprotection following stroke.
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miRNAs targeting several genes regulate microglia behavior and functions in diverse CNS pathologies.
“Recently, miRNAs targeting several genes are involved in regulating microglia behavior and functions in diverse CNS pathologies including ischemic brain injuries (Selvamani et al., 2012; Zhao et al., 2013; Karthikeyan et al., 2018), multiple sclerosis (Ponomarev et al., 2011) and prion disease (Saba et al., 2012; Slota and Booth, 2019).”
From miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A (2020) · cites this paper as Selvamani et al., 2012
The Results (no page available) show that anti-Let7f increased IGF-1 production in microglia harvested from ischemic cortex. The Discussion proposes that this may alter microglial activation, but does not establish broad regulation of microglial behavior and functions by miRNAs targeting several genes. This source supports an ischemic-injury example, not the broader claim by itself. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIGF-1 promotes neuroprotection and neuroregeneration.
“Some in vitro and in vivo studies have shown the role of IGF-1 in promoting neuroprotection and neuroregeneration (Li et al., 2010; Selvamani et al., 2012; Sohrabji and Williams, 2013; Bake et al., 2014).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Selvamani et al., 2012
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,825 · see citing works
The Diverse Functions of MicroRNAs in Animal Development and Disease
Kloosterman, W. P., & Plasterk, R. H. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.009 · Cited by 1,714 · see citing works
Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
Roush, S. F., & Slack, F. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.007 · Cited by 1,332 · see citing works
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187 · see citing works
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183 · see citing works
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923 · see citing works
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 878 · see citing works
Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain
Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874 · see citing works
Packer, A. N., Xing, Y., Harper, S. Q., Jones, L., & Davidson, B. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2390-08.2008 · Cited by 679 · see citing works
Jeyaseelan, K., Lim, K. Y., & Armugam, A. (2008) · Stroke · doi:10.1161/strokeaha.107.500736 · Cited by 586 · see citing works
Estradiol Protects against Ischemic Injury
Dubal, D. B., Kashon, M. L., Pettigrew, L. C., Ren, J. M., Finklestein, S. P., Rau, S. W., & Wise, P. M. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199811000-00012 · Cited by 554 · see citing works
Simpkins, J. W., Rajakumar, G., Zhang, Y. Q., Simpkins, C. E., Greenwald, D., Yu, C., Bodor, N. S., & Day, A. L. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.87.5.0724 · Cited by 509 · see citing works
Liu, D.-Z., Tian, Y., Ander, B. P., Xu, H., Stamova, B. S., Zhan, X., Turner, R. J., Jickling, G. C., & Sharp, F. R. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.186 · Cited by 496 · see citing works
Paxinos, G., WATSON, C. R. R., Pennisi, M., & Topple, A. N. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90026-3 · Cited by 483 · see citing works
Specificity, duplex degradation and subcellular localization of antagomirs
Krützfeldt, J., Kuwajima, S., Braich, R. S., Rajeev, K. G., Pena, J., Tuschl, T., Manoharan, M., & Stoffel, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm024 · Cited by 456 · see citing works
Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome
Dharap, A. A., Bowen, K. K., Place, R. F., Li, L., & Vemuganti, R. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.157 · Cited by 445 · see citing works
Wang, G., van der Walt, J. M., Mayhew, G. M., Li, Y., Zuchner, S. L., Scott, W. K., Martin, E. R., & Vance, J. M. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.021 · Cited by 441 · see citing works
MicroRNAs in Disease and Potential Therapeutic Applications
Soifer, H. S., Rossi, J. J., & Sætrom, P. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300311 · Cited by 394 · see citing works
Elia, L., Contu, R., Quintavalle, M., Varrone, F., Chimenti, C., Russo, M. A., Cimino, V., Marinis, L. D., Frustaci, A., Catalucci, D., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.879429 · Cited by 394 · see citing works
A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury
Gluckman, P. D., Klempt, N. D., Guan, J., Mallard, C. E., Sirimanne, E. S., Dragunow, M., Klempt, M., Singh, K., Williams, C., & Nikolics, K. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91774-k · Cited by 384 · see citing works
Laughlin, G. A., Barrett-Connor, E., Criqui, M. H., & Kritz-Silverstein, D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030967 · Cited by 374 · see citing works
Butovsky, O., Talpalar, A. E., Ben‐Yaakov, K., & Schwartz, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.005 · Cited by 368 · see citing works
A microRNA-based gene dysregulation pathway in Huntington's disease
Johnson, R., Zuccato, C., Belyaev, N. D., Guest, D. J., Cattaneo, E. F., & Buckley, N. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.001 · Cited by 360 · see citing works
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
Bhat‐Nakshatri, P., Wang, G., Collins, N., Thomson, M. J., Geistlinger, T., Carroll, J. S., Brown, M. A., Hammond, S. M., Srour, E. F., Liu, Y., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp500 · Cited by 345 · see citing works
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis
Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., Silani, V., Vos, P. E., Wokke, J. H. J., Dobbins, T., et al. (1998) · Neurology · doi:10.1212/wnl.51.2.583 · Cited by 339 · see citing works
Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
Beveridge, N. J., Tooney, P. A., Carroll, A. P., Gardiner, E. J., Bowden, N. A., Scott, R. J., Tran, N., Dedova, I. V., & Cairns, M. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn005 · Cited by 328 · see citing works
17β-Estradiol Reduces Stroke Injury in Estrogen-Deficient Female Animals
Rusa, R., Alkayed, N. J., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A., & Hurn, P. D. (1999) · Stroke · doi:10.1161/01.str.30.8.1665 · Cited by 304 · see citing works
miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
Yin, K., Deng, Z., Huang, H., Hamblin, M., Xie, C., Zhang, J., & Chen, Y. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.021 · Cited by 292 · see citing works
Lu, L., Katsaros, D., de la Longrais, I. A. R., Sochirca, O., & Yu, H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2544 · Cited by 282 · see citing works
Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction.
Shan, Z., Lin, Q., Fu, Y.-H., Deng, C.-Y., Zhou, Z.-L., Zhu, J.-N., Liu, X.-Y., Zhang, Y.-Y., Li, Y.-X., Lin, S.-G., et al. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2009.02.097 · Cited by 206 · see citing works
MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia
Yang, G.-Y. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e330 · Cited by 190 · see citing works
Johnston, B. M., Mallard, C. E., Williams, C. E., & Gluckman, P. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118416 · Cited by 181 · see citing works
Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
Yu, X.-Y., Song, Y.-H., Geng, Y., Lin, Q.-X., Shan, Z., Shu-guang, L., & Li, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.025 · Cited by 177 · see citing works
Insulin-Like Growth Factor (IGF) I, -II, and IGF Binding Protein-3 and Risk of Ischemic Stroke
Johnsen, S. P., Hundborg, H. H., Sørensen, H. T., Ørskov, H., Tjønneland, A. M., Overvad, K., & Jørgensen, J. O. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2088 · Cited by 168 · see citing works
Sex Differences in Caspase Activation After Stroke
Liu, F., Li, Z., Li, J., Siegel, C. S., Yuan, R., & McCullough, L. D. (2009) · Stroke · doi:10.1161/strokeaha.108.538686 · Cited by 166 · see citing works
Yan, Y., Sailor, K. A., Vemuganti, R., & Dempsey, R. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04872.x · Cited by 148 · see citing works
Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings
Bartke, A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00387.x · Cited by 142 · see citing works
Granjon, A., Gustin, M., Rieusset, J., Lefai, É., Meugnier, E., Güller, I., Cerutti, C., Paultre, C. Z., Disse, E., RABASA-LHORET, R. P. R., et al. (2009) · Diabetes · doi:10.2337/db09-0165 · Cited by 142 · see citing works
IGF‐I and microglia/macrophage proliferation in the ischemic mouse brain
O'Donnell, S. L., Frederick, T. J., Krady, J. K., Vannucci, S. J., & Wood, T. L. (2002) · Glia · doi:10.1002/glia.10081 · Cited by 139 · see citing works
Woodlee, M. T., ASSEOGARCIA, A., ZHAO, X., LIU, S., Jones, T. A., & Schallert, T. J. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.09.005 · Cited by 137 · see citing works
Selvamani, A., & Sohrabji, F. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.014 · Cited by 136 · see citing works
Self-citationIntranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
Lin, S., Fan, L., Rhodes, P. G., & Cai, Z. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.021 · Cited by 132 · see citing works
Selvamani, A., & Sohrabji, F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0761-10.2010 · Cited by 130 · see citing works
Self-citationIGF-1 and Retinopathy of Prematurity in the Preterm Infant
Smith, L. E. H. (2005) · Neonatology · doi:10.1159/000087587 · Cited by 129 · see citing works
Biernaskie, J. A., Corbett, D., Peeling, J., Wells, J. E. A., & Lei, H. C. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1263 · Cited by 125 · see citing works
Mongroo, P. S., Noubissi, F. K., Cuatrecasas, M., Kalabis, J., King, C. E., Johnstone, C. N., Bowser, M., Castells, A., Spiegelman, V. S., & Rustgi, A. K. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3295 · Cited by 123 · see citing works
Sayeed, I., Wali, B., & Stein, D. G. (2007) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2007-00378 · Cited by 116 · see citing works
Sex Differences in Minocycline-Induced Neuroprotection after Experimental Stroke
Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.3 · Cited by 116 · see citing works
Schäbitz, W.-R., Hoffmann, T. T., Heiland, S., Kollmar, R., Bardutzky, J., Sommer, C., & Schwab, S. (2001) · Stroke · doi:10.1161/01.str.32.5.1226 · Cited by 116 · see citing works
The clinical potential of microRNAs
Budhu, A., Ji, J., & Wang, X. W. (2010) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-3-37 · Cited by 110 · see citing works
Insulin-Like Growth Factor-1 Reduces Postischemic White Matter Injury in Fetal Sheep
Guan, J., Bennet, L., George, S., Wu, D. H., Waldvogel, H. J., Gluckman, P. D., Faull, R. L. M., Crosier, P. S., & Gunn, A. J. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200105000-00003 · Cited by 107 · see citing works
Intracerebroventricular injection of microglia protects against focal brain ischemia
Kitamura, Y., Takata, K., Inden, M., Tsuchiya, D., Yanagisawa, D., Nakata, J., & Taniguchi, T. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.203 · Cited by 104 · see citing works
Hua, Y., Zhang, Y., & Ren, J. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01307.x · Cited by 98 · see citing works
Schwab, S., Spranger, M., Krempien, S., Hacke, W., & Bettendorf, M. (1997) · Stroke · doi:10.1161/01.str.28.9.1744 · Cited by 91 · see citing works
Reid, J. G., Nagaraja, A. K., Lynn, F. C., Drabek, R. B., Muzny, D. M., Shaw, C. A., Weiss, M. K., Naghavi, A. O., Khan, M. F., Zhu, H., et al. (2008) · Genome Research · doi:10.1101/gr.078246.108 · Cited by 91 · see citing works
Liu, X., Fawcett, J. R., Hanson, L. R., & Frey, W. H. (2004) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2004.01.005 · Cited by 90 · see citing works
Kocerha, J., Kauppinen, S., & Wahlestedt, C. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8066-1 · Cited by 84 · see citing works
WANG, J., Hayashi, T., Zhang, W. R., Sakai, K., Shiro, Y., & Abe, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02008-4 · Cited by 78 · see citing works
Sex differences in cerebral ischemia: Possible molecular mechanisms
Siegel, C. S., Turtzo, L. C., & McCullough, L. D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22406 · Cited by 74 · see citing works
Rizk, N. N., Myatt-Jones, J., Rafols, J. A., & Dunbar, J. C. (2007) · Endocrine · doi:10.1007/s12020-007-0012-0 · Cited by 59 · see citing works
Preconditioning and the developing brain
Hagberg, H., Dammann, O., Mallard, C. E., & Leviton, A. (2004) · Seminars in Perinatology · doi:10.1053/j.semperi.2004.10.006 · Cited by 53 · see citing works
Stroke in Women: Risk and Prevention Throughout the Lifespan
Bushnell, C. (2008) · Neurologic Clinics · doi:10.1016/j.ncl.2008.05.009 · Cited by 53 · see citing works
The Therapeutic Potential of microRNAs in Nervous System Damage, Degeneration, and Repair
Hutchison, E. R., Okun, E., & Mattson, M. P. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8086-x · Cited by 51 · see citing works
Estrogen's effects on central and circulating immune cells vary with reproductive age
Johnson, A. B., & Sohrabji, F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.006 · Cited by 47 · see citing works
Self-citationTakane, K., Fujishima, K., Watanabe, Y., Sato, A., Saito, N., Tomita, M., & Kanai, A. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-101 · Cited by 39 · see citing works
Barriers to intravenous tissue plasminogen activator for acute stroke therapy in women
Lisabeth, L. D., Brown, D. L., & Morgenstern, L. B. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80215-9 · Cited by 35 · see citing works
IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.
Trojan, L. A., Kopinski, P., Wei, M., Ly, A., Głogowska, A., Czarny, J., Shevelev, A., Przewłocki, R., Hénin, D., & Trojan, J. (2002) · Acta Biochimica Polonica · doi:10.18388/abp.2002_3757 · Cited by 19 · see citing works
‘Sex, neuroprotection, and neonatal ischemia’
Renolleau, S., Fau, S., Goyenvalle, C., & Charriaut‐Marlangue, C. (2007) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2007.00477.x · Cited by 16 · see citing works
Prevention of breast cancer: the case for studying inhibition of IGF-1 actions
Smith, J. A., Axelrod, D., Singh, B., & Kleinberg, D. L. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq666 · Cited by 14 · see citing works
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The biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 724 · see citing works
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works
Estrogens, Neuroinflammation, and Neurodegeneration
Villa, A., Vegeto, E., Poletti, A., & Maggi, A. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1007 · Cited by 423 · see citing works
MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer’s disease
Banzhaf‐Strathmann, J., Benito, E., May, S., Arzberger, T., Tahirovic, S., Kretzschmar, H., Fischer, A., & Edbauer, D. (2014) · The EMBO Journal · doi:10.15252/embj.201387576 · Cited by 326 · see citing works
Baumann, V., & Winkler, J. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.116 · Cited by 300 · see citing works
Mellios, N., Feldman, D., Sheridan, S. D., Ip, J. P. K., Kwok, S., Amoah, S. K., Rosen, B. P., Rodriguez, B. A., Crawford, B., Swaminathan, R., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.86 · Cited by 288 · see citing works
Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair
Zárate, S., Stevnsner, T., & Gredilla, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00430 · Cited by 286 · see citing works
MicroRNA-based therapeutics in central nervous system injuries
Sun, P., Liu, D., Jickling, G. C., Sharp, F. R., & Yin, K. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18773871 · Cited by 256 · see citing works
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B. N., Wu, G. F., & Miller, T. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt261 · Cited by 236 · see citing works
Suh, H.-S., Zhao, M.-L., Derico, L., Choi, N., & Lee, S. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-37 · Cited by 226 · see citing works
Sex differences in the brain: Implications for behavioral and biomedical research
Choleris, E., Galea, L. A. M., Sohrabji, F., & Frick, K. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.005 · Cited by 214 · see citing works
Self-citationEpigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
Neal, M. P., & Richardson, J. R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.004 · Cited by 185 · see citing works
Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
Khoshnam, S. E., Winlow, W., Farbood, Y., Moghaddam, H. F., & Farzaneh, M. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01368 · Cited by 156 · see citing works
Doeppner, T. R., Doehring, M., Bretschneider, E., Zechariah, A., Kaltwasser, B., Müller, B., Koch, J. C., Bähr, M., Hermann, D. M., & Michel, U. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1142-5 · Cited by 155 · see citing works
Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia
Mehta, S. L., Pandi, G., & Vemuganti, R. (2017) · Stroke · doi:10.1161/strokeaha.117.017469 · Cited by 154 · see citing works
Sabirzhanov, B. E., Zhao, Z., Stoica, B. A., Loane, D. J., Wu, J., Borroto, C., Dorsey, S. G., & Faden, A. I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1260-14.2014 · Cited by 152 · see citing works
Angiogenesis-regulating microRNAs and Ischemic Stroke
Yin, K., Hamblin, M., & Chen, Y. (2015) · Current Vascular Pharmacology · doi:10.2174/15701611113119990016 · Cited by 152 · see citing works
Sex differences in stroke: Review of current knowledge and evidence
Girijala, R. L., Sohrabji, F., & Bush, R. L. (2016) · Vascular Medicine · doi:10.1177/1358863x16668263 · Cited by 146 · see citing works
Self-citationmicroRNAs: innovative targets for cerebral ischemia and stroke
Ouyang, Y.-B., Stary, C., Yang, G.-Y., & Giffard, R. (2012) · Current Drug Targets · doi:10.2174/138945013804806424 · Cited by 141 · see citing works
Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms
Gu, Y., Zhou, C., Piao, Z. H., Yuan, H., Jiang, H., Wei, H., Zhou, Y., Nan, G., & Ji, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.988283 · Cited by 134 · see citing works
Diagnosis, Prognosis and Therapeutic Role of Circulating miRNAs in Cardiovascular Diseases
Sayed, A. S. M., Xia, K., Salma, U., Yang, T., & Peng, J. (2014) · Heart Lung and Circulation · doi:10.1016/j.hlc.2014.01.001 · Cited by 132 · see citing works
Mehta, S. L., Kim, T., & Vemuganti, R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2943-15.2015 · Cited by 131 · see citing works
Tu, Y., Wan, L., Fan, Y., Wang, K., Bu, L., Huang, T., Cheng, Z., & Shen, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075872 · Cited by 127 · see citing works
Emerging Role of MicroRNAs in Cardiovascular Diseases
Rosa, S. D., Curcio, A., & Indolfi, C. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0086 · Cited by 119 · see citing works
Peripheral biomarkers of stroke: Focus on circulatory microRNAs
Vijayan, M., & Reddy, P. H. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.003 · Cited by 115 · see citing works
40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain
Gubbi, S., Quipildor, G. F., Barzilai, N., Huffman, D. M., & Milman, S. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0093 · Cited by 115 · see citing works
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works
Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy
Clossen, B. L., & Reddy, D. S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.003 · Cited by 115 · see citing works
MicroRNAs Expression and Function in Cerebral Ischemia Reperfusion Injury
Yu, D., Yang, L., Feng, Y., Fan, C., Wang, S., & Mo, X. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0293-8 · Cited by 113 · see citing works
Non-coding RNAs and neuroprotection after acute CNS injuries
Chandran, R., Mehta, S. L., & Vemuganti, R. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.015 · Cited by 111 · see citing works
Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery
Felling, R. J., & Song, H. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.09.017 · Cited by 111 · see citing works
Sex, stroke, and inflammation: The potential for estrogen-mediated immunoprotection in stroke
Ritzel, R. M., Capozzi, L. A., & McCullough, L. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.007 · Cited by 107 · see citing works
Zhao, H., Tao, Z., Wang, R., Liu, P., Yan, F., Li, J., Zhang, C., Ji, X., & Luo, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.055 · Cited by 102 · see citing works
Selvamani, A., Williams, M. H., Miranda, R. C., & Sohrabji, F. (2014) · Clinical Science · doi:10.1042/cs20130565 · Cited by 99 · see citing works
Self-citationSex differences in Alzheimer’s disease: Understanding the molecular impact
Toro, C. A., Zhang, L., Cao, J., & Cai, D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.031 · Cited by 97 · see citing works
Bake, S., Selvamani, A., Cherry, J., & Sohrabji, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091427 · Cited by 98 · see citing works
Self-citationBrain Response to Injuries: When Microglia Go Sexist
Rahimian, R., Cordeau, P., & Križ, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.048 · Cited by 95 · see citing works
Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases
Xia, X., Wang, Y., & Zheng, J. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.01.003 · Cited by 87 · see citing works
The emerging role of micro RNA s in cardiovascular disease
Mäegdefessel, L. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12298 · Cited by 88 · see citing works
Liu, D., Jickling, G. C., Ander, B. P., Hull, H., Zhan, X., Cox, C. D., Shroff, N., Dykstra-Aiello, C., Stamova, B. S., & Sharp, F. R. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610786 · Cited by 84 · see citing works
Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy
Younus, I., & Reddy, D. S. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.002 · Cited by 83 · see citing works
MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury
Hu, Y. H., Deng, H., Xu, S., & Zhang, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024895 · Cited by 81 · see citing works
Yan, B., Zhao, L., Guo, J., & Zhao, J. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.079590 · Cited by 82 · see citing works
Estrogen-IGF-1 interactions in neuroprotection: Ischemic stroke as a case study
Sohrabji, F. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.003 · Cited by 81 · see citing works
Self-citationInvolvement of MicroRNA in Microglia-Mediated Immune Response
Guedes, J. R., Cardoso, A. L., & de Lima, M. C. P. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/186872 · Cited by 79 · see citing works
microRNAs in Cerebrovascular Disease
Volný, O., Kašičková, L., Coufalová, D., Cimflová, P., & Novák, J. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_9 · Cited by 76 · see citing works
PreImplantation factor promotes neuroprotection by targeting microRNA let-7
Mueller, M., Zhou, J., Yang, L., Gao, Y., Wu, F., Schoeberlein, A., Surbek, D., Barnea, E. R., Paidas, M. J., & Huang, Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411674111 · Cited by 77 · see citing works
MicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke
Peng, G., Yuan, Y., Wu, S., He, F., Hu, Y., & Luo, B. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0422-x · Cited by 76 · see citing works
Sex differences in stroke therapies
Sohrabji, F., Park, M. J., & Mahnke, A. H. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23855 · Cited by 76 · see citing works
Self-citationmiR-711 upregulation induces neuronal cell death after traumatic brain injury
Sabirzhanov, B. E., Stoica, B. A., Zhao, Z., Loane, D. J., Wu, J., Dorsey, S. G., & Faden, A. I. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.132 · Cited by 76 · see citing works
Epigenetics and the Modulation of Neuroinflammation
Garden, G. A. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0207-4 · Cited by 70 · see citing works
Non-Coding RNAs in Stroke and Neuroprotection
Saugstad, J. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00050 · Cited by 71 · see citing works
All’s well that transcribes well: Non-coding RNAs and post-stroke brain damage
Vemuganti, R. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.07.014 · Cited by 71 · see citing works
The Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke
Khoshnam, S. E., Winlow, W., & Farzaneh, M. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx036 · Cited by 69 · see citing works
Mellios, N., Woodson, J., Garcia, R. I., Crawford, B., Sharma, J., Sheridan, S. D., Haggarty, S. J., & Sur, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309426111 · Cited by 69 · see citing works
Danka Mohammed, C. P., Park, J. S., Nam, H. G., & Kim, K. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.01.007 · Cited by 68 · see citing works
Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia
Habib, P., Dreymueller, D., Ludwig, A., Beyer, C., & Dang, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.06.003 · Cited by 67 · see citing works
Chakrabarti, M., Das, A., Samantaray, S., Smith, J. A., Banik, N. L., Haque, A., & Ray, S. K. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0032 · Cited by 65 · see citing works
Age and sex differences in the pathophysiology of acute CNS injury
Kim, T., Chelluboina, B., Chokkalla, A. K., & Vemuganti, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.012 · Cited by 63 · see citing works
MicroRNA-206 Regulation of Skin Pigmentation in Koi Carp (Cyprinus carpio L.)
Dong, Z., Luo, M., Wang, L., Yin, H., Zhu, W., & Fu, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00047 · Cited by 61 · see citing works
El-Hakim, Y., Mani, K. K., Eldouh, A., Pandey, S., Grimaldo, M. T., Dabney, A. R., Pilla, R., & Sohrabji, F. (2021) · Biology of Sex Differences · doi:10.1186/s13293-020-00352-1 · Cited by 58 · see citing works
Self-citationTsai, P.-C., Bake, S., Balaraman, S., Rawlings, J. A., Holgate, R., DuBois, D. W., & Miranda, R. C. (2014) · Biology Open · doi:10.1242/bio.20147765 · Cited by 59 · see citing works
Self-citationNeuroprotection of microRNA in neurological disorders (Review)
Wang, C., Ji, B., Cheng, B., Chen, J., & Bai, B. (2014) · Biomedical Reports · doi:10.3892/br.2014.297 · Cited by 58 · see citing works
Regulatory function of microRNAs in microglia
Brites, D. M. T. O. (2020) · Glia · doi:10.1002/glia.23846 · Cited by 55 · see citing works
The Involvement of miRNA in Carotid-Related Stroke
Maitrias, P., Meuth, V. M., Nader, J., Reix, T., Caus, T., & Metzinger, L. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309233 · Cited by 56 · see citing works
MicroRNA and diseases: Therapeutic potential as new generation of drugs
Wahid, F., Khan, T., & Kim, Y. Y. (2014) · Biochimie · doi:10.1016/j.biochi.2014.05.004 · Cited by 54 · see citing works
Drug Delivery Systems for the Treatment of Ischemic Stroke
Rhim, T., Lee, D. Y., & Lee, M. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0959-2 · Cited by 54 · see citing works
Effect of Sex and Age Interactions on Functional Outcome after Stroke
Kim, T., & Vemuganti, R. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12346 · Cited by 56 · see citing works
The Emerging Role of Epigenetics in Cerebral Ischemia
Hu, Z., Zhong, B., Tan, J., Chen, C., Qiang, L., & Zeng, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9788-3 · Cited by 53 · see citing works
MicroRNAs: a novel promising therapeutic target for cerebral ischemia/reperfusion injury?
Wang, T., Min, X., Wang, T.-Y., Cao, Y., Liu, J., & Li, J. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.170302 · Cited by 50 · see citing works
The complexity, function and applications of RNA in circulation
Etheridge, A., Gomes, C. P. C., Pereira, R. W., Galas, D. J., & Wang, K. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00115 · Cited by 51 · see citing works
Wu, Y., Yao, J., & Feng, K. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02931-0 · Cited by 48 · see citing works
Noncoding RNA crosstalk in brain health and diseases
Mehta, S. L., Chokkalla, A. K., & Vemuganti, R. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105139 · Cited by 47 · see citing works
Mueller, M., Schoeberlein, A., Zhou, J., Joerger-Messerli, M. S., Oppliger, B., Reinhart, U., Bordey, A., Surbek, D., Barnea, E. R., Huang, Y., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.55 · Cited by 47 · see citing works
Hypothermia and brain inflammation after cardiac arrest
Geocadin, R. G., Tahsili‐Fahadan, P., & Farrokh, S. (2018) · Brain Circulation · doi:10.4103/bc.bc_4_18 · Cited by 46 · see citing works
Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review
Yao, Y., Zhang, Y., Liao, X., Yang, R., Lei, Y., & Luo, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.618819 · Cited by 44 · see citing works
Mir363-3p improves ischemic stroke outcomes in female but not male rats
Selvamani, A., & Sohrabji, F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.008 · Cited by 44 · see citing works
Self-citationWindow of opportunity: Estrogen as a treatment for ischemic stroke
Liu, R., & Yang, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.023 · Cited by 43 · see citing works
Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke
Jickling, G. C., Ander, B. P., Shroff, N., Orantia, M., Stamova, B. S., Dykstra-Aiello, C., Hull, H., Zhan, X., Liu, D., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003354 · Cited by 42 · see citing works
Sarkar, S. N., Russell, A. E., Engler-Chiurazzi, E. B., Porter, K. N., & Simpkins, J. W. (2018) · Aging and Disease · doi:10.14336/ad.2018.0409 · Cited by 42 · see citing works
Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke.
Liu, W., Chen, X., & Zhang, Y. (2016) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Inflammasomes are neuroprotective targets for sex steroids
Slowik, A., & Beyer, C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.02.013 · Cited by 40 · see citing works
Innate and adaptive immune response in stroke: Focus on epigenetic regulation
Picascia, A., Grimaldi, V., Iannone, C., Soricelli, A., & Claudio Napoli, A. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.10.013 · Cited by 40 · see citing works
Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury
Peplow, P., & Martinez, B. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.191196 · Cited by 40 · see citing works
miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A
Gupta, N., Jadhav, S., Tan, K.-L., Saw, G., Mallilankaraman, K. B., & Dheen, S. T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00132 · Cited by 40 · see citing works
Sun, M., Li, M., Huang, Q., Han, F., Gu, J., Xie, J., Han, R., Qin, Z., & Zhou, Z. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.09.006 · Cited by 39 · see citing works
MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
Devaux, Y., Stammet, P., Friberg, H., Hassager, C., Kuiper, M. A., Wise, M. P., & Nielsen, N. (2015) · Critical Care · doi:10.1186/s13054-015-0767-2 · Cited by 39 · see citing works
Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury
Kaur, P., Liu, F., Tan, J., Lim, K. J., Sepramaniam, S., Karolina, D. S., Armugam, A., & Jeyaseelan, K. (2013) · Brain Sciences · doi:10.3390/brainsci3010360 · Cited by 38 · see citing works
Li, G., Ma, Q., Wang, R., Fan, Z., Tao, Z., Liu, P., Zhao, H., & Luo, Y. (2018) · Aging and Disease · doi:10.14336/ad.2017.0602 · Cited by 38 · see citing works
Honarpisheh, P., & McCullough, L. D. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14675 · Cited by 38 · see citing works
Wang, Z., Wang, J., Chen, Z., Wang, K., & Shi, L. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0015 · Cited by 37 · see citing works
Sex differences in microRNA expression during developmentin rat cortex
Murphy, S. J., Lusardi, T. A., Phillips, J. I., & Saugstad, J. A. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.06.007 · Cited by 37 · see citing works
Let‐7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin
Yan, S., Han, X., Xue, H., Zhang, P., Guo, X. H., Li, T., Guo, X., Yuan, G., Deng, L., & Li, G. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25128 · Cited by 36 · see citing works
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea, E. R., Almogi‐Hazan, O., Or, R., Mueller, M., Ria, F., Weiss, L., & Paidas, M. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.10.008 · Cited by 34 · see citing works
Tackling Aging by Using miRNA as a Target and a Tool
Lai, W., Lin, M., & Wong, W. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.007 · Cited by 34 · see citing works
MicroRNAs and Ethanol Toxicity
Miranda, R. C. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00007-x · Cited by 33 · see citing works
Self-citationGelosa, P., Castiglioni, L., Rzemieniec, J., Muluhie, M., Camera, M., & Sironi, L. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02154-3 · Cited by 33 · see citing works
Majdi, A., Mahmoudi, J., Sadigh‐Eteghad, S., Farhoudi, M., & Shotorbani, S. S. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2643-5 · Cited by 32 · see citing works
Let-7g* and miR-98 Reduce Stroke-Induced Production of Proinflammatory Cytokines in Mouse Brain
Bernstein, D. L., & Rom, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00632 · Cited by 32 · see citing works
- Authors
- Selvamani, A., Sathyan, P., Miranda, R. C., & Sohrabji, F.
- Affiliations
- Texas A&M Health Science Center (US)
- Corresponding author
- Sohrabji, Farida
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-02-29
- Volume
- 7
- Issue
- 2
- Pages
- e32662
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3290559
- OpenAlex
- W2071432376
- Cited by
- 217
- References
- 79
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 16 · 2019: 19 · 2018: 18 · 2017: 26 · 2016: 20 · 2015: 23 · 2014: 27 · 2013: 22 · 2012: 4
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- OakTrust (Texas A&M University Libraries) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG027684, AG027684, AG028303, R01AG028303)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- ischemic stroke, neuroprotection, microRNA, let-7f, miR-1, insulin-like growth factor I, IGF-1 signaling, microglia, sex differences, infarct size, sensorimotor function, hemispheric integration, sex steroids
- MeSH terms
- Animals, Behavior, Animal, Disease Models, Animal, Female, Gene Expression Regulation, Insulin-Like Growth Factor I, Ischemia, Male, Sex Factors, Reperfusion Injury, Microglia, Neuroprotective Agents, Stroke, MicroRNAs, Rats
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