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ATP-binding cassette transporter A1: From metabolism to neurodegeneration
Open accessAbstract
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport - a role that determines its importance for atherosclerosis. Over the last 10 years studies have provided convincing evidence that ABCA1, via its control of apoE lipidation, also has a role in Alzheimer's disease (AD). A series of reports have revealed a significant impact of ABCA1 on Aβ deposition and clearance in AD model mice, as well as an association of common and rare ABCA1 gene variants with the risk for AD. Since APOE is the major genetic risk factor for late onset AD, the regulation of apoE level or its functionality by ABCA1 may prove significant for AD pathogenesis. ABCA1 is transcriptionally regulated by Liver X Receptors (LXR) and Retinoic X Receptors (RXR) which provides a starting point for drug discovery and development of synthetic LXR and RXR agonists for treatment of metabolic and neurodegenerative disorders. This review summarizes the recent results of research on ABCA1, particularly relevant to atherosclerosis and AD.
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“In addition to its role in lipid transport, ABCA1 also indirectly facilitates amyloid β clearance through ApoE lipidation in brain [6].”
From Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease (2017) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Deletion of ABCA1 gene increases amyloid β accumulation, whereas its overexpression prevents amyloid β aggregation in amyloid mouse models [6].”
From Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease (2017) · cites this paper as [6]
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“Agonists of these nuclear receptors increased the levels of ABCA1 and decreased amyloid β accumulation in APP mouse models [6].”
From Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease (2017) · cites this paper as [6]
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“ATP-binding cassette transporter A1 (ABCA1) is a major cholesterol transporter that transfers cellular cholesterol onto lipid-poor apolipoproteins and regulates ApoE lipidation in the brain (Koldamova et al., 2014).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Koldamova et al., 2014
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“Previous animal studies demonstrated that improvement of ApoE lipidation inhibits amyloid deposition in APP mouse models.”
From Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease (2017) · cites this paper as [6]
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Items 101–145 of 145
Darabi, M. K., Rafeeinia, A., Pezeshki, S. P., Nazeri, Z., Kheirollah, A., & Cheraghzadeh, M. (2025) · The FASEB Journal · doi:10.1096/fj.202401167rr · Cited by 2
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ApoE: A Risk Factor for Dementia
Jeelani, H., Nabi, J., Akhter, Y., Tabasum, N., Afroze, D., Pottoo, F. H., & Ali, F. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_1 · Cited by 2
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Pang, K. S., Peng, H., Li, B. P., Wen, B., Noh, K., Xia, R., Toscan, A., Serson, S., Fraser, P. E., Tirona, R. G., et al. (2024) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2386 · Cited by 1
“Brain cholesterol is continuously being shed from the plasma membrane by transporters ABCG1/ ABCG5 and ABCA1, the ATP binding cassette subfamily A member 1 (Koldamova et al., 2014), and is metabolized by CYP46A1, the cholesterol 24(S) ‐ hydroxylase in neurons to 24(S) ‐ hydrox-ycholesterol.”
BackgroundExpanding the role of alpha lipoic acid for psychiatric and neurological health
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Laham, M. S., Ackerman-Berrier, M. S., Alam, F., Turner, S., Velma, G. R., Penton, C., Musku, S. R., Rana, M., Kumar, S., Anandhan, A., et al. (2025) · eLife · doi:10.7554/elife.109146.1 · Cited by 1
Lipidated APOE has effects on cognitive function that are independent of amyloid-β pathology
Corona, A. W., & Landreth, G. E. (2015) · Brain · doi:10.1093/brain/awv300
Nakayama, S., Mitsunaga, F., Maeda, A., & Nakamura, S. (2016) · Food and Nutrition Sciences · doi:10.4236/fns.2016.79076
“KE administration also upregulated the expression of hepatic ABCA1, which played a role in cholesterol efflux to HDL apoproteins, apoA-1 and apoE, and regulated the pathogenesis of atherosclerosis and/or Alzheimer’s disease [43].”
BackgroundInfluentialCastranio, E. L. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
A study of the global effects of Apolipoprotein E using lipidomics
Hawksworth, J. I. (2019) · ORCA Online Research @Cardiff (Cardiff University)
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MicroRNA-29c-3p in Dual-Labeled Exosome is Potential Marker of Alzheimer's DiseasePreprint
Li, Y., Xia, M., Meng, S., Wu, D., Ling, S., Chen, X., & Liu, C. (2021) · Research Square · doi:10.21203/rs.3.rs-934448/v1
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Imaging blood-brain barrier function in aging
Verheggen, I. C. M. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210601iv
Liao, S., Zhou, Q., & Zhang, Y. (2023) · Journal of Genetics · doi:10.1007/s12041-023-01424-y
“To date, a variety of epidemiological studies have focussed on the associations between the ABCA1 gene polymorphisms and several human diseases, such as cardiovascular disease (Yin et al. 2015) and Alzheimer’s disease (Koldamova et al. 2014).”
BackgroundA Brief Review on Alzheimer’s Disease
Suvitha, D., Dhivya, P., Saraswathy, T., & Ahamed Nisha, K. (2023) · International Journal of Pharmacy and Pharmaceutical Research · doi:10.25166/ijppr.2023.27.2.66
Chakraborty, S., Parashar, R., Jha, N. K., Jha, A. K., & Jha, S. K. (2023) · Springer eBooks · doi:10.1007/978-3-030-81404-5_58-1
Chakraborty, S., Parashar, R., Jha, N. K., Jha, A. K., & Jha, S. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-28109-9_58
Oxisteróis e sua relação com a neuroinflamação na esclerose lateral amiotrófica
Lima, R. S. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2023.tde-12122023-105206
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Liu, S. K., Cao, H., Yang, X., Zhou, X., Chen, Y., Fu, W., Chan, S. Y., Ip, F. C. F., Mok, K. Y., Mok, V., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251350722
“35 Therefore, to examine the effect of ABCA1 R219 K on cholesterol ef fl ux, we overexpressed WT ABCA1 or the R219 K mutant in human glioblastoma U87 cells.”
Machowska, M., Leszek, J., Rączy-Krzemianowska, M., Tomasiewicz, B., Hurkacz, M., Rąpała, M., Piechota, J., Głowacka, K., & Wiela−Hojeńska, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110759
Laham, M. S., Ackerman-Berrier, M. S., Alam, F., Turner, S., Velma, G. R., Penton, C., Musku, S. R., Rana, M., Thulasingam, S., Anandhan, A., et al. (2025) · eLife · doi:10.7554/elife.109146
“Therefore, the beneficial role of ABCA1 in CNS disorders may derive from central actions and peripheral effects ( Koldamova et al., 2014 ; Tang et al., 2019 ).”
Zhai, X., Hu, Y., Xu, X., Xu, X., Ma, B., Huang, D., Liu, H., Li, H., Hu, Y., & Jiang, H. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20250144
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APOE, Biomarkers, and Proteogenomics in Alzheimer’s Disease
Pereira, J. D., Tosatti, J. A. G., & Gomes, K. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-52641-1_66-1
The Role of ApoE Genetics in Glial Lipid Metabolism and Inflammation
Julia, T. C. W., Negi, R., & Kurkela, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_74-1
Laham, M. S., Ackerman-Berrier, M. S., Alam, F., Turner, S., Velma, G. R., Penton, C., Musku, S. R., Rana, M., Thulasingam, S., Anandhan, A., et al. (2026) · eLife · doi:10.7554/elife.109146.2
APOE, Biomarkers, and Proteogenomics in Alzheimer’s Disease
Pereira, J. D., Tosatti, J. A. G., & Gomes, K. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_66
The Role of ApoE Genetics in Glial Lipid Metabolism and Inflammation
Julia, T. C. W., Negi, R., & Kurkela, M. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_74
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Apolipoprotein E in Alzheimer’s disease: Genetic predisposition and mechanistic implications
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Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation
Lv, W., Deng, W., Deng, F., Xu, S., & Ren, W. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70200
BindingDB Entry 50018264: Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
BindingDB (2024) · UC San Diego · doi:10.7270/q27p93md
Metadata
- Authors
- Koldamova, R., Fitz, N. F., & Lefterov, I.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Koldamova, Radosveta
- Lefterov, Iliya
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 72
- Pages
- 13-21
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC4302328
- OpenAlex
- W2013375919
- Cited by
- 144
- References
- 146
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 6 · 2023: 18 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 2
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH (R01AG037481, R01AG037919, R21ES021243, K01AG044490)
- DOD (W81XWH-13-1-0384)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- ABCA1, ABC transporters, Alzheimer's disease, atherosclerosis, reverse cholesterol transport, high-density lipoprotein, apolipoprotein E, apolipoprotein A-I, amyloid-beta clearance, liver X receptor, retinoid X receptor, LXR agonists, RXR agonists, cholesterol efflux, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Brain, Disease Models, Animal, Humans, Risk Factors, Tangier Disease, Amyloid beta-Peptides, Atherosclerosis, Mice, ATP Binding Cassette Transporter 1
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