The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Glia and alpha-synuclein in neurodegeneration: A complex interaction
Open accessAbstract
α-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) that are characterized by α-synuclein (AS) aggregates in neurons or glia. PD and DLB feature neuronal AS-positive inclusions termed Lewy bodies (LB) whereas glial cytoplasmic inclusions (GCIs, Papp-Lantos bodies) are recognized as the defining hallmark of MSA. Furthermore, AS-positive cytoplasmic aggregates may also be seen in astroglial cells of PD/DLB and MSA brains. The glial AS-inclusions appear to trigger reduced trophic support resulting in neuronal loss. Moreover, microgliosis and astrogliosis can be found throughout the neurodegenerative brain and both are key players in the initiation and progression of ASP. In this review, we will highlight AS-dependent alterations of glial function and their impact on neuronal vulnerability thereby providing a detailed summary on the multifaceted role of glia in ASP.
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Cites
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Cited by
How neuroinflammation contributes to neurodegeneration
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Neuroinflammation as a common feature of neurodegenerative disorders
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Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
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Metadata
- Authors
- Brück, D., Wenning, G. K., Stefanova, N., & Fellner, L.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 85
- Pages
- 262-274
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2076569898
- Cited by
- 202
- References
- 46
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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