The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Liability to substance use disorders: 1. Common mechanisms and manifestations
Abstract
Variation in the risk for and severity of substance use disorders (SUD) in the population is caused by multiple organismic (genetic, biochemical, psychological) and environmental factors. Whereas drug- or drug-class-specific liability mechanisms exist, a substantial proportion of variance in the risk is shared between specific liabilities, reflecting mechanisms that determine common liability to SUD. Data from epidemiologic, clinical, psychological, physiological, biochemical, and family and genetic studies reviewed in this paper indicate the existence of mechanisms and characteristics shared in common by liabilities to SUD related to different drugs. These mechanisms can be conceptualized as common liability to SUD, a latent trait accounting for a substantial portion of variation in SUD risk and severity and determined by all factors influencing the probability of SUD development. An accompanying paper describes an approach to the quantitative estimation of this trait.
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“TLI was shown to predict substance use disorders in adolescence and young adulthood.”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Vanyukov et al., 2003
Citations
Cites
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Flagged first, then by citations
Research works printed but not linked: 3
- Vanyukov, 2000, Antisociality, substance dependence, and the DRD5 gene: a preliminary study, Am J Med Genet, 96, 654, 10.1002/1096-8628(20001009)96:5<654::AID-AJMG11>3.0.CO;2-Y · DOI
- Young, 2000, Genetic and environmental influences on behavioral disinhibition, Am J Med Genet, 96, 684, 10.1002/1096-8628(20001009)96:5<684::AID-AJMG16>3.0.CO;2-G · DOI
- Bardo, 1996, Psychobiology of novelty seeking and drug seeking behavior, Behav Brain Res, 77, 23, 10.1016/0166-4328(95)00203-0 · DOI · Paper page
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Items 201–205 of 205
Benca‐Bachman, C. E., Najera, D. D., Delawalla, C. N., Jaume-Feliciosi, N., McGeary, J. E., & Palmer, R. H. C. (2025) · Research Square · doi:10.21203/rs.3.rs-6157562/v1
“…rationale behind the TLI stems from the theory that shared and non-shared genetic and environmental factors across multiple behaviors and traits contribute to individual differences in substance use disorder (SUD) liability among individuals in families and the broader population [22, 23].”
The neuropsychological deficits in cannabis users : does motivation play a role?
Ericson, R. F. (2010) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/2ybw-r787
Richards, V. L., Oliver, J. A., Pan, S. J., Frank-Pearce, S. G., Smith, M. A., Nagawa, C. S., & Cohn, A. M. (2025) · Addictive Behaviors · doi:10.1016/j.addbeh.2025.108504
Cohn, A. M., Romm, K. F., Vogel, E. A., Pan, S., Frank-Pearce, S. G., Smith, M. A., Appleseth, H. S., Boozary, L. K., Sifat, M., & Kendzor, D. E. (2026) · Addictive Behaviors · doi:10.1016/j.addbeh.2026.108742
Miglin, R., & Sadeh, N. (2026) · Substance Use & Misuse · doi:10.1080/10826084.2026.2689088
“…the creation of comprehensive models that aim to capture the real-world complexity of this spectrum of disorders (Carroll, 2021) and several biopsychosocial models of SUD severity have been proposed (Belcher et al., 2014; Gori et al., 2022; Skewes & Gonzalez, 2013; Vanyukov et al., 2003).”
Metadata
- Authors
- Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Vanyukov, Michael M
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 27
- Issue
- 6
- Pages
- 507-515
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2000690643
- Cited by
- 205
- References
- 92
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 9 · 2012: 22
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da011922-05)
- National Institute on Alcohol Abuse and Alcoholism (R01AA011637, K02AA000291, K02-AA00291)
- National Institute on Drug Abuse (R01-DA011922, P50DA005605)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- substance use disorders, latent traits, genetic susceptibility, environmental risk factors, biochemical factors, psychological factors
- MeSH terms
- Brain Chemistry, Disease Susceptibility, Humans, Phenotype, Risk Factors, Sex Factors, Social Environment, Causality, Precipitating Factors, Substance-Related Disorders, Genetic Predisposition to Disease
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