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Cited by 205Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Liability to substance use disorders: 1. Common mechanisms and manifestations

Vanyukov, Michael M, Tarter, Ralph E, Kirisci, Levent, Kirillova, Galina P, Maher, Brion S, Clark, Duncan B·2003·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2003.08.002
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Abstract

Variation in the risk for and severity of substance use disorders (SUD) in the population is caused by multiple organismic (genetic, biochemical, psychological) and environmental factors. Whereas drug- or drug-class-specific liability mechanisms exist, a substantial proportion of variance in the risk is shared between specific liabilities, reflecting mechanisms that determine common liability to SUD. Data from epidemiologic, clinical, psychological, physiological, biochemical, and family and genetic studies reviewed in this paper indicate the existence of mechanisms and characteristics shared in common by liabilities to SUD related to different drugs. These mechanisms can be conceptualized as common liability to SUD, a latent trait accounting for a substantial portion of variation in SUD risk and severity and determined by all factors influencing the probability of SUD development. An accompanying paper describes an approach to the quantitative estimation of this trait.

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Crossref · 10.1016/j.neubiorev.2003.08.002

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Research works printed but not linked: 3

  1. Vanyukov, 2000, Antisociality, substance dependence, and the DRD5 gene: a preliminary study, Am J Med Genet, 96, 654, 10.1002/1096-8628(20001009)96:5<654::AID-AJMG11>3.0.CO;2-Y · DOI
  2. Young, 2000, Genetic and environmental influences on behavioral disinhibition, Am J Med Genet, 96, 684, 10.1002/1096-8628(20001009)96:5<684::AID-AJMG16>3.0.CO;2-G · DOI
  3. Bardo, 1996, Psychobiology of novelty seeking and drug seeking behavior, Behav Brain Res, 77, 23, 10.1016/0166-4328(95)00203-0 · DOI · Paper page

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Metadata

Authors
Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B.
Affiliations
University of Pittsburgh (US)
Corresponding author
Vanyukov, Michael M
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2003-10
Volume
27
Issue
6
Pages
507-515
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2003.08.002
OpenAlex
W2000690643
Cited by
205
References
92
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 9 · 2012: 22
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da011922-05)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA011637, K02AA000291, K02-AA00291)
  • National Institute on Drug Abuse (R01-DA011922, P50DA005605)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
substance use disorders, latent traits, genetic susceptibility, environmental risk factors, biochemical factors, psychological factors
MeSH terms
Brain Chemistry, Disease Susceptibility, Humans, Phenotype, Risk Factors, Sex Factors, Social Environment, Causality, Precipitating Factors, Substance-Related Disorders, Genetic Predisposition to Disease

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