Cited by 205Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

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Liability to substance use disorders: 1. Common mechanisms and manifestations

Vanyukov, Michael M, Tarter, Ralph E, Kirisci, Levent, Kirillova, Galina P, Maher, Brion S, Clark, Duncan B·2003·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2003.08.002

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Abstract

Variation in the risk for and severity of substance use disorders (SUD) in the population is caused by multiple organismic (genetic, biochemical, psychological) and environmental factors. Whereas drug- or drug-class-specific liability mechanisms exist, a substantial proportion of variance in the risk is shared between specific liabilities, reflecting mechanisms that determine common liability to SUD. Data from epidemiologic, clinical, psychological, physiological, biochemical, and family and genetic studies reviewed in this paper indicate the existence of mechanisms and characteristics shared in common by liabilities to SUD related to different drugs. These mechanisms can be conceptualized as common liability to SUD, a latent trait accounting for a substantial portion of variation in SUD risk and severity and determined by all factors influencing the probability of SUD development. An accompanying paper describes an approach to the quantitative estimation of this trait.

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Items 101–200 of 205

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Kirisci, L., Tarter, R. E., Reynolds, M., Ridenour, T. A., Stone, C. A., & Vanyukov, M. M. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.016 · Cited by 21
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Vaughn, M. G., Beaver, K. M., & DeLisi, M. (2009) · Youth Violence and Juvenile Justice · doi:10.1177/1541204008330409 · Cited by 22
“We employ the term liability similarly to Vanyukov et al. (2003a, 2003b), wherein liability to a disorder is attributable to a complex variation of genetic polymorphisms, neural substrates, temperament and personality, and distal and proximal environmental variables.”
Method
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White, H. R., Jackson, K. M., & Loeber, R. (2009) · Handbooks of Sociology and Social Research · doi:10.1007/978-1-4419-0245-0_21 · Cited by 34
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“First, aggression and substance use initiation may be specific manifestations of more general underlying disinhibitory control problems.(7,8) Second, aggression can be conceptualized as an externalizing behavior with a strong affective component.”
Background
Nonmedical Cannabis Use: Patterns and Correlates of Use, Exposure, and Harm, and Cancer Risk
Cohn, A. M., Blount, B. C., & Hashibe, M. (2021) · JNCI Monographs · doi:10.1093/jncimonographs/lgab006 · Cited by 20
Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder
Kirisci, L., Tarter, R., Ridenour, T., Reynolds, M., Horner, M., & Vanyukov, M. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.10.028 · Cited by 19
“TLI was derived using a previously described multistage procedure (Vanyukov et al., 2003a,b).”
Method
Longitudinal Modeling of Transmissible Risk in Boys Who Subsequently Develop Cannabis Use Disorder
Kirisci, L., Tarter, R. E., Ridenour, T. A., Reynolds, M., & Vanyukov, M. M. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.774009 · Cited by 19
“In contrast to scales measuring temperament, personality and motivation borrowed from other fields of research that have been utilized in virtually all studies to investigate the psychological antecedents of SUD, the TLI was specifically derived according to theory regarding SUD etiology (3).”
BackgroundMethodInfluential
Rural and urban comparisons of polysubstance use profiles and associated injection behaviors among people who inject drugs in Puerto Rico
Hautala, D. S., Abadie, R., Khan, B., & Dombrowski, K. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.09.030 · Cited by 20
“These patterns across diverse populations of PWID suggests that polysubstance use is normative (rather than restricted to a small subset) within the PWID population—and may reflect a common liability for polysubstance use among heavy substance users everywhere (Vanyukov et al., 2003).”
Genetic Relationship Between the Addiction Diagnosis in Adults and Their Childhood Measure of Addiction Liability
Vanyukov, M. M., Kim, K., Irons, D. E., Kirisci, L., Neale, M. C., Ridenour, T. A., Hicks, B. M., Tarter, R. E., Reynolds, M., Kirillova, G. P., et al. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9684-4 · Cited by 18
Risk and resistance perspectives in translation-oriented etiology research
Vanyukov, M. M., Tarter, R. E., Conway, K. P., Kirillova, G. P., Chandler, R. K., & Daley, D. C. (2015) · Translational Behavioral Medicine · doi:10.1007/s13142-015-0355-7 · Cited by 17
“These associations and other commonalities between the liabilities to drug-specific SUDs suggest common sources of variation, termed general/common liability to addiction, GLA [32, 35, 36].”
Background
Adolescent Life History Strategy in the Intergenerational Transmission and Developmental Stability of Substance Use
Richardson, G. B., Dai, C., Chen, C., Nedelec, J. L., Swoboda, C. M., & Chen, W. (2016) · Journal of Drug Issues · doi:10.1177/0022042615623986 · Cited by 19
Measuring the temporal association between cannabis and tobacco use among Co-using young adults using ecological momentary assessment
Wilhelm, J. A., Abudayyeh, H., Perreras, L., Taylor, R., Peters, E. N., Vandrey, R. G., Hedeker, D., Mermelstein, R. J., & Cohn, A. M. (2019) · Addictive Behaviors · doi:10.1016/j.addbeh.2019.106250 · Cited by 17
“There are several theoretical explanations for co-use, including shared predisposition to substance use (6, 33) mediated by genetic (34–36) and cultural/environmental (3, 34, 36) factors, as well as the “gateway” hypothesis (3, 10, 37, 38).”
Background
Stigmata that are desired: contradictions in addiction
Vanyukov, M. M. (2023) · Addiction Research & Theory · doi:10.1080/16066359.2023.2238603 · Cited by 16
“The common phenotypic variance is termed common (general) liability to addiction (Vanyukov et al. 2003; Vanyukov 2012).”
Background
The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees: its moderation by personal, family, and community factors
Kendler, K. S., Ohlsson, H., Bacanu, S., Sundquist, J., & Sundquist, K. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0111-8 · Cited by 16
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Loeber, R., Clark, D. B., Ahonen, L., FitzGerald, D., Trucco, E. M., & Zucker, R. A. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.03.011 · Cited by 18
“(Vanyukov et al., 2003a,b; 2009).”
Item Response Theory Analysis to Assess Dimensionality of Substance Use Disorder Abuse and Dependence Symptoms
Kirisci, L., Tarter, R. E., Reynolds, M., & Vanyukov, M. M. (2017) · The International Journal of Person Centered Medicine · doi:10.5750/ijpcm.v6i4.613 · Cited by 15
“in [4]) and the relationships among liabilities to drug-specific SUDs.”
BackgroundResult
Developmental trajectory classes in psychological dysregulation predict later decision-making competence
Weller, J. A., Parker, A. M., Reynolds, M., & Kirisci, L. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106650 · Cited by 14
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“…their markers of heavy nicotine and cannabis use, and significant engagement with dual use of smoked and vaped modes of delivery are consistent with common liability models of substance use, highlighting the importance of person-level characteristics in studies of co-use (Vanyukov et al., 2003).”
Method
Developmental perspective of substance use disorder etiology.
Tarter, R. E., Horner, M. S., & Ridenour, T. A. (2012) · American Psychological Association eBooks · doi:10.1037/13751-014 · Cited by 13
Infusing Neuroscience Into the Study and Prevention of Drug Misuse and Co-Occurring Aggressive Behavior
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“A complementary developmental model aligned with a behavior genetic framework has also been proposed (Vanyukov et al., 2003).”
Background
Does stress mediate the development of substance use disorders among youth transitioning to young adulthood?
Cornelius, J. R., Kirisci, L., Reynolds, M., & Tarter, R. E. (2014) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2014.895833 · Cited by 13
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“It addresses shared risk factors for alcohol and marijuana use (Vanyukov et al., 2003a, 2003b) using an advanced statistical technique, propensity score weighting.”
Method
A systematic review of gene-by-intervention studies of alcohol and other substance use
Neale, Z. E., Kuo, S. I., & Dick, D. M. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000590 · Cited by 15
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Liao, D., Cheng, M.-C., Lai, C.-H., Tsai, H., & Chen, C. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00390.x · Cited by 13
“Like the other substance use disorders, the development of heroin dependence results from the interactions between psychosocial factors and genetic predisposing factors (Vanyukov et al. 2003).”
Background
Application of person-centered medicine in addiction.
Tarter, R. E., Kirisci, L., Ridenour, T. A., & Bogen, D. L. (2012) · PubMed · Cited by 12
Introduction and Rationale for Individualized Substance Abuse Prevention from an Ontogenetic Perspective
Ridenour, T. A., & Stormshak, E. A. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990903005924 · Cited by 12
“However, evidence supports the widely-accepted ecological, multifactorial, and liability-threshold theories that manifold factors contribute to SA ontogeny (13, 14).”
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Cadoni, C., De Felice, M., Corongiu, S., Dessì, C., Espa, E., Melis, M., & Fenu, S. (2020) · Addiction Biology · doi:10.1111/adb.12803 · Cited by 10
Smoking Cessation for Those Pursuing Recovery from Substance Use Disorders
Derefinko, K. J., García, F. I. S., & Sumrok, D. D. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.02.014 · Cited by 10
Temperament disturbances measured in infancy progress to substance use disorder 20years later
Horner, M. S., Reynolds, M., Braxter, B., Kirisci, L., & Tarter, R. E. (2015) · Personality and Individual Differences · doi:10.1016/j.paid.2015.03.001 · Cited by 10
“Detailed description of the theory and method of TLI development can be found in Vanyukov et al. (2003).”
Method
Quick screen to detect current substance use disorder in adolescents and the likelihood of future disorder
Kirisci, L., Reynolds, M., Carver, D., & Tarter, R. E. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.08.017 · Cited by 8
Identifying trajectories of alcohol use in a sample of secondary school students in Ontario and Alberta: longitudinal evidence from the COMPASS study
Gohari, M. R., Dubin, J. A., Cook, R. J., & Leatherdale, S. T. (2019) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.39.8/9.02 · Cited by 9
Estimation of BDNF gene polymorphism and predisposition to dependence development for selected psychoactive compounds
Biskupska, J., Borowiak, K. S., Karlin-Grażewicz, K., Janus, T., Waloszczyk, P., Potocka‐Banaś, B., Machoy‐Mokrzyńska, A., Ossowski, A., & Ciechanowicz, A. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112459203 · Cited by 9
“Most of divergences in earlier results can be explained by a high heterogeneity of the studied population, stratification effect, clinical course of disorders and different clinical and diagnostic criteria for studied and control groups.(14,15) Therefore, the umbilical infant blood from the same population was used as…”
Result
Relation among HPA and HPG neuroendocrine systems, transmissible risk and neighborhood quality on development of substance use disorder: Results of a 10-year prospective study
Tarter, R. E., Kirisci, L., Kirillova, G. P., Reynolds, M., Gavaler, J. S., Ridenour, T. A., Horner, M. S., Clark, D. B., & Vanyukov, M. M. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.07.008 · Cited by 9
Alcohol substitution during one month of cannabis abstinence among non-treatment seeking youth
Schuster, R. M., Potter, K. W., Lamberth, E., Rychik, N., Hareli, M., Allen, S. E., Broos, H. C., Mustoe, A. K., Gilman, J. M., Pachas, G. N., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110205 · Cited by 10
Translating Genetics, Cognitive Science, and Other Basic Science Research Findings Into Applications for Prevention
Ames, S. L., & McBride, C. M. (2006) · Evaluation & the Health Professions · doi:10.1177/0163278706290407 · Cited by 9
“Advances in understanding of human genetics, and now more than a decade of research in behavioral genetics, suggest that variation in trait-based susceptibility is heritable (e.g., Vanyukov et al., 2003).”
Background
First use of cannabis compared to first use of alcohol and tobacco: Associations with single and poly-substance use behavior.
Cohn, A. M., & Elmasry, H. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109904 · Cited by 8
Family Functioning as a Mediator of Relations Between Family History of Substance Use Disorder and Impulsivity
Ryan, S. R., Friedman, C. K., Liang, Y., Lake, S. L., Mathias, C. W., Charles, N. E., Acheson, A., & Dougherty, D. M. (2015) · Addictive Disorders & Their Treatment · doi:10.1097/adt.0000000000000070 · Cited by 10
“There is substantial research suggesting that offspring of parents with a history of drug use demonstrate higher levels of impulsivity.(4) One hypothesis for this link is a genetic transmission of impulsivity.”
Background
Factores predictores del consumo de alcohol en adolescentes: datos de un estudio prospectivo de 1 año de seguimiento
Serrano, M. B., Al‐Halabí, S., Burón, P., Garrido, M., Díaz-Mesa, E., Galván, G., García-Álvarez, L., Velasco, Á., Wasserman, C., Carli, V., et al. (2018) · Adicciones · doi:10.20882/adicciones.998 · Cited by 9
Genetics and Epigenetics of Substance Use
Vanyukov, M. M., & Tarter, R. E. (2019) · Advances in prevention science · doi:10.1007/978-3-030-00627-3_4 · Cited by 8
Repeated Cocaine Intake Differentially Impacts Striatal D2/3 Receptor Availability, Psychostimulant-Induced Dopamine Release, and Trait Behavioral Markers of Drug Abuse
Urueña‐Méndez, G., Dimiziani, A., Bellés, L., Goutaudier, R., & Ginovart, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713238 · Cited by 7
“Besides the contribution of genetic and environmental risk factors [1], personality traits concerning impulsivity and novelty (or sensation) seeking are widely considered to contribute to the development of substance use disorders (SUD), due to their high prevalence in drug abusers [2–5], and their prospective associa…”
Background
Substance use and mating success
Richardson, G. B., Chen, C., Dai, C., Swoboda, C. M., Nedelec, J. L., & Chen, W. (2016) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2016.06.006 · Cited by 9
The Impact of Substance Use Disorder and Drug Transfer into Breast Milk: Implications for Maternal and Infant Health
Yang, Y., Yi, B., & Zhang, T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060719 · Cited by 7
“This disorder affects the brain’s reward, motivation, and memory systems, making it challenging for individuals to control their impulses and cravings [33,34].”
Positive associations between cannabis and alcohol use polygenic risk scores and phenotypic opioid misuse among African-Americans
Rabinowitz, J. A., Jin, J., Kuo, S. I., Campos, A. I., Rentería, M. E., Huhn, A. S., Thrul, J., Reboussin, B. A., Benke, K. S., Domingue, B. W., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266384 · Cited by 7
“[12], it is thought that there is a continuous latent trait, which is shared across drug classes, that is reflected in risk for developing a drug addiction.”
Background
Modeling the association between sexual maturation, transmissible risk, and peer relationships during childhood and adolescence on development of substance use disorder in young adulthood
Horner, M. S., Tarter, R. E., Kirisci, L., & Clark, D. B. (2013) · American Journal on Addictions · doi:10.1111/j.1521-0391.2013.12046.x · Cited by 7
Never, non-daily, and daily smoking status and progression to daily cigarette smoking as correlates of major depressive episode in a national sample of youth: Results from the National Survey of Drug Use and Health 2013 to 2015
Cohn, A. M. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.03.001 · Cited by 7
Forecasting Opioid Use Disorder at 25 Years of Age in 16-Year-Old Adolescents
Tarter, R. E., Kirisci, L., Cochran, G., Seybert, A. L., Reynolds, M., & Vanyukov, M. M. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.07.025 · Cited by 7
“—Previous reports describe the theory (21) and methods (8,22) guiding development and validation of the TLI.”
Background
Derivation and assessment of the opioid use disorder severity scale: prediction of health, psychological and social adjustment problems
Kirisci, L., Tarter, R. E., Reynolds, M., Hayes, K. N., Cochran, G., & Vanyukov, M. M. (2020) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2019.1707840 · Cited by 6
The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project
Vanyukov, M. M., MAES, H. H. M., Iacono, W. G., Kirisci, L., Samek, D. R., Silberg, J. L., Zimmerman, E. B., & Prom‐Wormley, E. C. (2023) · Twin Research and Human Genetics · doi:10.1017/thg.2023.8 · Cited by 6
A New Approach to Researching the Etiology of Cannabis Use Disorder: Integrating Transmissible and Nontransmissible Risk within a Developmental Framework
Tarter, R. E., Kirisci, L., & Reynolds, M. (2014) · Substance Abuse · doi:10.1080/08897077.2014.956918 · Cited by 6
“In adults, the TLI predicts that all substance use disorder categories(66) are commensurate with the common liability model of addiction etiology.(10,29,30,42,43) Development of the TLI employed a multistage procedure.”
Background
Informing Prevention and Intervention Policy Using Genetic Studies of Resistance
Maher, B. S., Latendresse, S. J., & Vanyukov, M. M. (2016) · Prevention Science · doi:10.1007/s11121-016-0730-8 · Cited by 6
“Such an index, for instance, has been developed for measurement liability to drug addiction in children, before any exposure to drugs (Vanyukov et al. 2003a, b; Vanyukov et al. 2009; Vanyukov et al. 2016).”
Determining non-cigarette tobacco, alcohol, and substance use typologies across menthol and non-menthol smokers using latent class analysis
Cohn, A. M., Johnson, A. L., Pearson, J., Rose, S. W., Ehlke, S. J., Ganz, O., & NIAURA, R. S. (2017) · Tobacco Induced Diseases · doi:10.1186/s12971-017-0111-5 · Cited by 6
“This may suggest a willingness to try new products or a vulnerability to engage in a variety of health-risk behaviors [56], which may impede efforts toward positive behavior change.”
Background
Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders
Vitkauskas, M., & Mathuru, A. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186525 · Cited by 5
“Epidemiological evidence suggests a co-occurrence with nicotine dependence [2,3], substance use disorders [3,4], anxiety disorders [5], insomnia, and chronic pain [6].”
Background
Drug Use among Residents of Juvenile Correctional Center in Kerman, Iran, and its Relationship with Personality Dimensions and Self-concept.
Gousheh, A., Ziaaddini, H., Baneshi, M. R., & Nakhaee, N. (2014) · Europe PMC (PubMed Central) · Cited by 5
Introduction to Metrics in Person Centered Medicine Research
Kirisci, L., Vanyukov, M. M., & Mezzich, J. E. (2017) · The International Journal of Person Centered Medicine · doi:10.5750/ijpcm.v6i4.611 · Cited by 5
“Statistical Manual categories of substance use disorder (SUD) share common liability variance.[4, 5] The liability model is currently the prevailing conceptualization of complex (polygenic, multifactorial) disorders, including general psychiatric and alcohol use disorders.”
Background
Problematic alcohol use among gay, bisexual, and other men who have sex with men in Canada: the role of proximal stressors and anxiety
Zahran, A., Dermody, S. S., Berlin, G. W., Palma, P. A., Skakoon‐Sparling, S., Noor, S. W. B., Lachowsky, N. J., Grace, D., Cox, J., Moore, D. M., et al. (2024) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-024-00597-8 · Cited by 4
“However, previous research has also shown support for other directional pathways, including the substance-induced distress hypothesis [73] and the shared-vulnerability hypothesis [74].”
Result
Substance Use Disorders
Abou‐Saleh, M. T., Tarter, R. E., & Salloum, I. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-39724-5_24 · Cited by 4
Was it the drink? The conditioned association of alcohol and desire to quit smoking on the dual use of little cigars/cigarillos and cigarettes among men and women
Ehlke, S. J., & Cohn, A. M. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.03.010 · Cited by 4
Visited a vape shop? Prevalence and correlates from a national sample of U.S. young adults
Rose, S. W., Cohn, A. M., Pearson, J., Johnson, A., Rath, J. M., & Villanti, A. C. (2016) · Tobacco Prevention & Cessation · doi:10.18332/tpc/65203 · Cited by 4
Relations between Positive Temperament, Substance Use, and Internalizing Problems among Adolescents and Young Adults with and without Medical Conditions
Davis, M., Eaton, C. K., Gutierrez‐Colina, A. M., Oshri, A., Blount, R. L., & Suveg, C. M. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2018.1429474 · Cited by 4
“The results for high intensity pleasure among healthy AYAs support a common liability model (Vanyukov et al., 2003), whereby a given characteristic underlies problematic substance use in multiple substance categories.”
Background
Do the Transmissible Liability Index (TLI) and Adolescent Cannabis Use Predict Paranoid and Schizotypal Symptoms at Young Adulthood?
Sharma, P., Riehm, K. E., Young, A. S., Reynolds, M., Tarter, R. E., Horner, M. S., & Hammond, C. J. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1964086 · Cited by 4
Substance Use: Disorders and Continuous Traits
Kirisci, L., & Vanyukov, M. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_1 · Cited by 4
Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder
Tarter, R. E., Kirisci, L., Reynolds, M., Horner, M. S., Zhai, Z. W., Gathuru, I. M., & Vanyukov, M. M. (2015) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000163 · Cited by 4
“The theory underlying development of the TLI (Vanyukov et al., 2003b), the methodology used to derive this index (Vanyukov et al., 2003a), and its psychometric properties (Kirisci et al., 2009; Vanyukov et al., 2009) have been described in detail.”
Method
Cognitive functioning in alcohol and other substance use disorders in young adulthood : A genetic epidemiological study
Latvala, A. (2011) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) · Cited by 4
Psychiatric comorbidity and progression in drug use in adult male twins: Implications for the design of genetic association studies
Todorov, A. A., Lynskey, M. T., Grant, J. D., Scherrer, J. F., Todd, R. D., & Bucholz, K. K. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.03.046 · Cited by 4
Advances in diagnosis of adolescent substance abuse.
Gray, K. M., Upadhyaya, H. P., Deas, D., & Brady, K. T. (2006) · PubMed · doi:10.1016/j.admecli.2006.03.011 · Cited by 4
Comprehensive Assessment of Substance Abuse and Addiction Risk in Adolescence
Wright, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-72778-3_3 · Cited by 3
Multilevel risk and protective factors for frequent and non-frequent past 30-day marijuana use: Findings from a representative sample of high school youth
Lensch, T., Drake, C. S., Clements-Nolle, K. D., & Pearson, J. (2023) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.22-00240 · Cited by 3
Dietary Modulation of the Behavioral Consequences of Psychoactive Drugs
D’Anci, K. E., Kanarek, R. B., Mathes, W. F., Leibovici, M., Coy, R. T., & Yamamoto, R. T. (2005) · Nutrition, brain, and behavior./Nutrition, brain and behavior · doi:10.1201/9780203564554.ch12 · Cited by 3
Psychological Antecedents and Correlates of Substance Use and Addiction
Tarter, R. E., & Reynolds, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_3 · Cited by 3
Transitioning from DSM-IV Abuse to Dependence: The Essence of Harmful Compulsive Substance Use is Ontogenetic and Dynamic
Ridenour, T. A. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.797988 · Cited by 2
“To illustrate the heterogeneity of the population that qualifies for an SUD, DSM-IV criteria allow for 466 combinations of symptoms/criteria to qualify for an SUD, related to the use of a particular drug (notwithstanding additional variance due to clinical judgment) (8).”
Background
Antecedents of hazardous teenage drinking: analysis of the 1970 British Cohort Study
Percy, A., & Iwaniec, D. (2008) · IOE EPrints · Cited by 2
Family and Adoption Studies of Substance Use
Stallings, M. C., Kent, K. R., & Frieser, M. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_5 · Cited by 3
Does the Transmissible Liability Index (TLI) assessed in late childhood predict suicidal symptoms at young adulthood?
Cornelius, J. R., Kirisci, L., Reynolds, M., Vanyukov, M. M., & Tarter, R. E. (2015) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2015.1011744 · Cited by 2
“The behavior genetic construct ‘‘transmissible risk’’ includes all genetic and environmental mechanisms underlying parent-child correlation for liability to an illness (3,5,6).”
Impulsivity, Peer Influence, and Adolescent Substance Use
Stautz, K. (2013) · Goldsmiths (University of London) · Cited by 2
Genome-wide association study identifies common genetic risk factors for alcohol, heroin and methamphetamine dependencePreprint
Sun, Y., Chang, S., Liu, Z., Zhang, L., Wang, F., Yue, W., Sun, H., Ni, Z., Chang, X., Zhang, Y., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/505917 · Cited by 2
The etiologic, theory-based, ontogenetic hierarchical framework of alcohol use disorder: a translational systematic review of reviews
Boness, C. L. (2021) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/90983 · Cited by 2
Decriminalization and police productivity: the 2018 Farm Bill’s effect on cannabis case processing time
Wilds, K. M., & WORRALL, J. L. (2025) · Police Practice and Research · doi:10.1080/15614263.2024.2440499 · Cited by 1
“And while there is evidence that cannabis and hard drug use are associated with one another, it is difficult to parse out the temporal ordering and rule out confounding variables (e.g., Vanyukov et al., 2003).”
The Youth Risk Index: psychometrics, predicting the initiation of early adolescent substance use, and the breadth of liability detected
Ridenour, T. A., Gottfredson, N. C., Williams, J. G., Shaw, D. S., Reynolds, M., Roberts, C. A., Spoth, R. L., Garnica-Agudelo, D., Baran, I., Belger, A., et al. (2025) · Frontiers in Child and Adolescent Psychiatry · doi:10.3389/frcha.2025.1513607 · Cited by 1
The relationship between inhalant use and adolescent gateway drug use sequencing: a latent transition analysis
Crankshaw, E. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/k1tf-y168 · Cited by 1
Assessing TLI as a Predictor of Treatment Seeking for SUD among Youth Transitioning to Young Adulthood.
Cornelius, J. R., & Kirisci, L. (2013) · PubMed · Cited by 1
Measuring the Abuse Liability of Video Games
Bassett, D. T. (2018) · Cited by 1
Ethical considerations in genetic research with children affected by parental substance abuse
McMahon, T. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139058971.006 · Cited by 1
The role of attachment to parents in the etiology of substance use disorder
Zhai, Z. W. (2015) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth
Hulvershorn, L. A., Hummer, T. A., Wu, Y., Tarter, R. E., Rea, P., Anand, A., Chambers, R. A., & Finn, P. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9679-x · Cited by 1
“Furthermore, family history alone is a limited indicator of risk status because the majority of youths whose parents have a drug use disorder do not develop this disorder, and most youths who develop SUD do not have an affected parent (Vanyukov et al. 2003b).”
Influential
Avaliação do perfil de comorbidades, gravidade da dependência e motivação para o tratamento em uma amostra de usuários de maconha que procuram tratamento
Júnior, H. P. D. O. (2010) · doi:10.11606/d.5.2010.tde-02062010-101805 · Cited by 1
Substance use profiles from ages 11 to 18: personality correlates and relations with emerging adult adjustment.
Oliva, E. M. (2009) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 1
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 313 Maternal Separation in Rats An Experimental Model for Long-Term Effects of Early Life Experiences on Neurochemistry, Voluntary Ethanol Intake and Exploration and Risk Assessment Behavior
Roman, E. (2004)
Avaliação do perfil de comorbidades, gravidade da dependência e motivação para o tratamento em uma amostra de usuários de maconha que procuram tratamento
Malbergier, A. (2010)
Integrating longitudinal twin research and measured genetic variation to test developmental theories of behavioral disinhibition and adolescent substance use.
Vrieze, S. I. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Trace amine associated receptors : a new target for medications in drug addiction
Cotter, R. (2012) · UC Research Repository (University of Canterbury) · doi:10.26021/5624
Alcohol exposure and the developing human brain
Bjork, J. M. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511757402.018
Acculturation, Family Context, and Mexican Origin Youth Substance Use Risk Across Time
Cruz, R. A. (2014) · ResearchWorks at the University of Washington (University of Washington)
BIG TOBACCO. BIG MARIJUANA? LONGITUDINAL TRENDS AND MULTI-DIRECTIONAL TOBACCO AND MARIJUANA USE AMONG YOUTH AND YOUNG ADULTS IN TEXAS
Rogers, S. M. (2019) · Digital Commons-TMC (Texas Medical Center)
Understanding Youth Trajectories of Alcohol Use: Evaluating the Impact of a Policy of Authorizing Alcohol Sales in Some Grocery Stores in Ontario
Gohari, M. R. (2019) · UWSpace (University of Waterloo)
Facts Versus Fiction in Adolescent Substance Use: Implications for Public Health
Schick, M. R., Nalven, T., Crawford, M. C., Kirk‐Provencher, K. T., & Spillane, N. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_10-1
Linkage and Association Studies of Substance Use Disorders
Maher, B. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_7
Facts Versus Fiction in Adolescent Substance Use: Implications for Public Health
Schick, M. R., Nalven, T., Crawford, M. C., Kirk‐Provencher, K. T., & Spillane, N. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_10
Genetic Influences in Opioid Use Disorder
Maher, B. S., & Rabinowitz, J. A. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197618431.013.7
THE ROLE OF A FAMILY IN POLITOXICOMANIA OXICOMANIA
Šapić, R., Krvokapić, Ž., Nenadović, M., & Krivokapić, M. (2008) · Praxis medica · doi:10.70949/pramed200801221s

Authors: Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B.
Affiliations: University of Pittsburgh (US)
Corresponding author: Vanyukov, Michael M
ORCID: Vanyukov, Michael M
Tarter, Ralph E
Kirisci, Levent
Maher, Brion S
Clark, Duncan B
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2003-10
Volume: 27
Issue: 6
Pages: 507-515
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2003.08.002
OpenAlex: W2000690643
Cited by: 205
References: 92
Citations by year: 2026: 2 · 2025: 5 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 9 · 2012: 22
FWCI: 1.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da011922-05)
National Institute on Alcohol Abuse and Alcoholism (R01AA011637, K02AA000291, K02-AA00291)
National Institute on Drug Abuse (R01-DA011922, P50DA005605)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: substance use disorders, latent traits, genetic susceptibility, environmental risk factors, biochemical factors, psychological factors
MeSH terms: Brain Chemistry, Disease Susceptibility, Humans, Phenotype, Risk Factors, Sex Factors, Social Environment, Causality, Precipitating Factors, Substance-Related Disorders, Genetic Predisposition to Disease

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Liability to substance use disorders: 1. Common mechanisms and manifestations

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