The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Mechanisms of action of deep brain stimulation (DBS)
Abstract
Deep brain stimulation (DBS) is remarkably effective for a range of neurological and psychiatric disorders that have failed pharmacological and cell transplant therapies. Clinical investigations are underway for a variety of other conditions. Yet, the therapeutic mechanisms of action are unknown. In addition, DBS research demonstrates the need to re-consider many hypotheses regarding basal ganglia physiology and pathophysiology such as the notion that increased activity in the globus pallidus internal segment is causal to Parkinson's disease symptoms. Studies reveal a variety of apparently discrepant results. At the least, it is unclear which DBS effects are therapeutically effective. This systematic review attempts to organize current DBS research into a series of unifying themes or issues such as whether the therapeutic effects are local or systems-wide or whether the effects are related to inhibition or excitation. A number of alternative hypotheses are offered for consideration including suppression of abnormal activity, striping basal ganglia output of misinformation, reduction of abnormal stochastic resonance effects due to increased noise in the disease state, and reinforcement of dynamic modulation of neuronal activity by resonance effects.
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“Also, deep brain stimulation (DBS) is suggested and demonstrated to activate or inhibit brain signals for neurological disease such as Parkinson's disease, essential tremor, dystonia, chronic pain, and major depression.29,30”
From From flexible electronics technology in the era of IoT and artificial intelligence toward future implanted body sensor networks (2019) · cites this paper as [29]
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Metadata
- Authors
- Montgomery, E. B., & Gale, J. T.
- Affiliations
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Corresponding author
- Montgomery, Erwin B.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 32
- Issue
- 3
- Pages
- 388-407
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2143662434
- Cited by
- 344
- References
- 109
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 12 · 2020: 12 · 2019: 18 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 24 · 2014: 27 · 2013: 28 · 2012: 38
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (C06RR020141, RR 15459-01, C06RR015459, RR 020141-01, P51RR000167)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, mechanism of action, basal ganglia, Parkinson's disease, globus pallidus internus, therapeutic effects, stochastic resonance, basal ganglia output, neuropsychiatric disorders
- MeSH terms
- Basal Ganglia, Humans, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Parkinson Disease, Deep Brain Stimulation
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