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Cited by 864Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Fone, Kevin C.F., Porkess, M. Veronica·2008·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2008.03.003
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Abstract

Exposing mammals to early-life adverse events, including maternal separation or social isolation, profoundly affects brain development and adult behaviour and may contribute to the occurrence of psychiatric disorders, such as depression and schizophrenia in genetically predisposed humans. The molecular mechanisms underlying these environmentally induced developmental adaptations are unclear and best evaluated in animal paradigms with translational salience. Rearing rat pups from weaning in isolation, to prevent social contact with conspecifics, produces reproducible, long-term changes including; neophobia, impaired sensorimotor gating, aggression, cognitive rigidity, reduced prefrontal cortical volume and decreased cortical and hippocampal synaptic plasticity. These alterations are associated with hyperfunction of mesolimbic dopaminergic systems, enhanced presynaptic dopamine (DA) and serotonergic (5-HT) function in the nucleus accumbens (NAcc), hypofunction of mesocortical DA and attenuated 5-HT function in the prefrontal cortex and hippocampus. These behavioural, morphological and neurochemical abnormalities, as reviewed herein, strongly resemble core features of schizophrenia. Therefore unravelling the mechanisms that trigger these sequelae will improve our knowledge of the aetiology of neurodevelopmental psychiatric disorders, enable identification of longitudinal biomarkers of dysfunction and permit predictive screening for novel compounds with potential antipsychotic efficacy.

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Crossref · 10.1016/j.neubiorev.2008.03.003

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Research works printed but not linked: 4

  1. Harte, 2006, Deficits in parvalbumin and calbindin immunoreactivity in the hippocampus of isolation reared rats, Schizophr. Res., 81, 210
  2. King, 2007, The novel 5-HT6 receptor antagonist, PRX-07037, enhances memory and reduces food intake in a neurodevelopmental model of schizophrenia, J. Psychopharmacol., 21, A57
  3. Porkess, 2006, Aniracetam has no effect on isolation rearing induced hyperactivity, PPI deficits or passive avoidance impairment in rats, but does improve novel object recognition, J. Psychopharmacology, 20, A46
  4. Porkess, 2007, Isolation rearing of rats induces a reduction in prefrontal cortex volume measured by MR volumetry, J. Psychopharmacology, 21, A57

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Metadata

Authors
Fone, K. C. F., & Porkess, M. V.
Affiliations
University of Nottingham (GB)
Corresponding author
Fone, Kevin C.F.
ORCID
Fone, Kevin C.F.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2008-08
Volume
32
Issue
6
Pages
1087-1102
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2008.03.003
OpenAlex
W2019243277
Cited by
864
References
208
Citations by year
2026: 28 · 2025: 34 · 2024: 37 · 2023: 46 · 2022: 41 · 2021: 64 · 2020: 51 · 2019: 47 · 2018: 41 · 2017: 62 · 2016: 50 · 2015: 71 · 2014: 55 · 2013: 57 · 2012: 54
FWCI
5.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
post-weaning social isolation, maternal separation, childhood adversity, schizophrenia, depression, neophobia, sensorimotor gating, aggression, synaptic plasticity, mesolimbic dopamine system, mesocortical dopamine, nucleus accumbens, serotonin, prefrontal cortex, hippocampus, brain development, biomarkers
MeSH terms
Animals, Animals, Newborn, Behavior, Animal, Brain Chemistry, Child, Developmental Disabilities, Disease Models, Animal, Humans, Rodentia, Social Isolation

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