Cited by 440Autism Spectrum Disorder ResearchMaternal Mental Health During Pregnancy and PostpartumFamily and Disability Support Research

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Prenatal stress and risk for autism

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KINNEY, D, MUNIR, K, CROWLEY, D, MILLER, A·2008·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2008.06.004PMC PMC2632594

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Abstract

This paper reviews several converging lines of research that suggest that prenatal exposure to environmental stress may increase risk for Autistic Disorder (AD). We first discuss studies finding that prenatal exposure to stressful life events is associated with significantly increased risk of AD, as well as other disorders, such as schizophrenia and depression. We then review evidence from animal and human studies that prenatal stress can produce both (a) abnormal postnatal behaviors that resemble the defining symptoms of AD, and (b) other abnormalities that have elevated rates in AD, such as learning deficits, seizure disorders, perinatal complications, immunologic and neuroinflammatory anomalies, and low postnatal tolerance for stress. We explain why an etiologic role for prenatal stress is compatible with genetic factors in AD, and describe how stress can disrupt fetal brain development. Finally, we discuss implications for understanding underlying processes in AD, including potential gene-environment interactions, and developing new therapies and early prevention programs.

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Authors: KINNEY, D., MUNIR, K., CROWLEY, D., & MILLER, A.
Affiliations: Harvard University (US)
McLean Hospital (US)
Corresponding author: KINNEY, D
ORCID: CROWLEY, D
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2008-10
Volume: 32
Issue: 8
Pages: 1519-1532
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2008.06.004
PMC: PMC2632594
OpenAlex: W2025653580
Cited by: 440
References: 112
Citations by year: 2026: 7 · 2025: 16 · 2024: 28 · 2023: 19 · 2022: 23 · 2021: 33 · 2020: 28 · 2019: 20 · 2018: 20 · 2017: 35 · 2016: 33 · 2015: 32 · 2014: 28 · 2013: 45 · 2012: 32
FWCI: 6.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH 071286, R25MH071286)
Fogarty International Center (D43TW005807)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords: prenatal stress, autism spectrum disorder, autistic disorder, environmental stressors, life events, schizophrenia, depression, learning deficits, epilepsy, perinatal complications, neuroinflammation, stress tolerance, fetal brain development, gene-environment interaction, autism etiology, prevention
MeSH terms: Autistic Disorder, Female, Humans, Male, Parent-Child Relations, Pregnancy, Prenatal Exposure Delayed Effects, Risk, Stress, Psychological

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