Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex‐dependent way
Open accessAbstract
Exposures to prenatal maternal depressive symptoms (PMDS) may lead to neurodevelopmental changes in the offspring in a sex‐dependent way. Although a connection between PMDS and infant brain development has been established by earlier studies, the relationship between PMDS exposures measured at various prenatal stages and microstructural alterations in fundamental subcortical structures such as the amygdala remains unknown. In this study, we investigated the associations between PMDS measured during gestational weeks 14, 24 and 34 and infant amygdala microstructural properties using diffusion tensor imaging. We explored amygdala mean diffusivity (MD) alterations in response to PMDS in infants aged 11 to 54 days from birth. PMDS had no significant main effect on the amygdala MD metrics. However, there was a significant interaction effect for PMDS and infant sex in the left amygdala MD. Compared with girls, boys exposed to greater PMDS during gestational week 14 showed significantly higher left amygdala MD. These results indicate that PMDS are linked to infants' amygdala microstructure in boys. These associations may be relevant to later neuropsychiatric outcomes in the offspring. Further research is required to better understand the mechanisms underlying these associations and to develop effective interventions to counteract any potential adverse consequences.
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Male offspring exposed to greater maternal depressive symptoms at 14 GW show higher left amygdala mean diffusivity (MD) compared with females.
“Compared with females, male offspring exposed to greater maternal depressive symptoms at 14 GW show higher left amygdala mean diffusivity (MD) [17].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [17]
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- tb02031.x · DOI · Paper page
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- Authors
- Hashempour, N., Tuulari, J. J., Merisaari, H., Acosta, H., Lewis, J. D., Pelto, J., Scheinin, N. M., Fonov, V. S., Collins, D. L., Lehtola, S. J., Saunavaara, J., Lähdesmäki, T., Parkkola, R., Karlsson, L., & Karlsson, H.
- Affiliations
- University of Turku (FI)
- Montreal Neurological Institute and Hospital (CA)
- Turku University Hospital (FI)
- FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine University of Turku Turku Finland
- Corresponding author
- Hashempour, Niloofar
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2023-05
- Volume
- 57
- Issue
- 10
- Pages
- 1671-1688
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W4365135202
- Cited by
- 20
- References
- 96
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 7 · 2023: 1
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Funders
- Turun yliopiston tutkijakoulu
- Orionin Tutkimussäätiö
- Emil Aaltosen Säätiö
- Juho Vainion Säätiö
- Jane ja Aatos Erkon Säätiö
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Signe ja Ane Gyllenbergin Säätiö
- Academy of Finland (134950, 253270, 264363 (HK), 308176 (LK), 26080983 (HM))
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- left amygdala, sex differences, mean diffusivity, infant brain development, gestational age, prenatal stress, neurodevelopmental outcomes
- MeSH terms
- Amygdala, Brain, Depression, Female, Humans, Infant, Infant, Newborn, Male, Pregnancy, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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