Cited by 440Autism Spectrum Disorder ResearchMaternal Mental Health During Pregnancy and PostpartumFamily and Disability Support Research

The DOI matches its Crossref record; 111 of the 112 references it cites were found in a registry or an index.

Prenatal stress and risk for autism

Open access

KINNEY, D, MUNIR, K, CROWLEY, D, MILLER, A·2008·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2008.06.004PMC PMC2632594

Open this paper in CoChat — free account

Abstract

This paper reviews several converging lines of research that suggest that prenatal exposure to environmental stress may increase risk for Autistic Disorder (AD). We first discuss studies finding that prenatal exposure to stressful life events is associated with significantly increased risk of AD, as well as other disorders, such as schizophrenia and depression. We then review evidence from animal and human studies that prenatal stress can produce both (a) abnormal postnatal behaviors that resemble the defining symptoms of AD, and (b) other abnormalities that have elevated rates in AD, such as learning deficits, seizure disorders, perinatal complications, immunologic and neuroinflammatory anomalies, and low postnatal tolerance for stress. We explain why an etiologic role for prenatal stress is compatible with genetic factors in AD, and describe how stress can disrupt fetal brain development. Finally, we discuss implications for understanding underlying processes in AD, including potential gene-environment interactions, and developing new therapies and early prevention programs.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2008.06.004

Cites

111 of 111 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Handbook of Autism and Pervasive Developmental Disorders
(2005) · Wiley eBooks · doi:10.1002/9780470939352 · Cited by 2,258
Temperament: Early Developing Personality Traits
Buss, A. H., & Plomin, R. J. (1984) · Research Portal (King's College London) · Cited by 2,164
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 2×
“7.3 Immunologic and Neuroinflammatory Abnormalities Analyses of post-mortem brain tissue of AD patients (Vargas et al., 2005) have found signs of neuroinflammatory activity in the cerebellum and cerebral cortex.”
BackgroundInfluential
Prevalence of autism spectrum disorders--autism and developmental disabilities monitoring network, 14 sites, United States, 2002.
(2007) · PubMed · Cited by 2,018
Comparing the Strengths and Difficulties Questionnaire and the Child Behavior Checklist: Is Small Beautiful?
Goodman, R., & Scott, S. (1999) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022658222914 · Cited by 1,420
The Extreme Male-Brain Theory of Autism
Baron‐Cohen, S. (1999) · The MIT Press eBooks · doi:10.7551/mitpress/4945.003.0023 · Cited by 1,414
Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why?
Talge, N. M., Neal, C., Glover, V., & the Early Stress, T. R. A. P. S. N. F. A. N. E. O. C. A. A. M. H. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01714.x · Cited by 1,349
Gene–environment interactions in psychiatry: joining forces with neuroscience
Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300
The genetics of autism
Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207
Sex differences in the brain: implications for explaining autism
Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005) · Science · doi:10.1126/science.1115455 · Cited by 1,145
Pervasive Developmental Disorders in preschool children
Chakrabarti, S. (2001) · JAMA · doi:10.1001/jama.285.24.3093 · Cited by 1,132
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058
Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044 · cited 1×
“Prenatally stressed rats have also shown delayed learning in a task requiring spatial memory (Lemaire et al., 2000).”
Background
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984
Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
Meaney, M. J., & Szyf, M. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.2/mmeaney · Cited by 958
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928
PSYCHOSOCIAL ASSETS, LIFE CRISIS AND THE PROGNOSIS OF PREGNANCY12
Nuckolls, K. B., Cassel, J. C., & Kaplan, B. H. (1972) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a121410 · Cited by 807
Prenatal maternal stress: effects on pregnancy and the (unborn) child
Mulder, E. J. H., Robles de Medina, P. G., Huizink, A. C., Van den Bergh, B. R. H., Buitelaar, J. K., & Visser, G. H. A. (2002) · Early Human Development · doi:10.1016/s0378-3782(02)00075-0 · Cited by 779
Untitled work
(2005) · PubMed · Cited by 775
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727
Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis
O’Connor, T. G., Heron, J., Golding, J., Glover, V. A. S., & the AL SPAC Study Team (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00187 · Cited by 725
The genetics of autistic disorders and its clinical relevance: a review of the literature
Freitag, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001896 · Cited by 638
High Antenatal Maternal Anxiety Is Related to ADHD Symptoms, Externalizing Problems, and Anxiety in 8- and 9-Year-Olds
den Bergh, B. R. H. V., & Marcoen, A. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00727.x · Cited by 627
Perinatal risk factors for infantile autism
Hultman, C. M., Sparén, P., & Cnattingius, S. (2002) · Epidemiology · doi:10.1097/00001648-200207000-00009 · Cited by 561
Perinatal Factors and the Development of Autism
Glasson, E. J., Bower, C. I., Petterson, B., de Klerk, N. H., Chaney, G., & Hallmayer, J. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.6.618 · Cited by 542
Does Prenatal Stress Impair Coping and Regulation of Hypothalamic-Pituitary-Adrenal Axis?
Weinstock, M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00014-0 · Cited by 539
Emery and Rimoin's Principles and Practice of Medical Genetics
Rimoin, D. L. (1997) · Cited by 523
Neurotoxicity of Glucocorticoids in the Primate Brain
Uno, H., Eisele, S., Sakai, A., Shelton, S. E., Baker, E. H., DeJesus, O. T., & Holden, J. E. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1030 · Cited by 511
Prenatal exposure to maternal stress and subsequent schizophrenia
van Os, J., & Selten, J. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.4.324 · Cited by 481
Continuous Emotional Support During Labor in a US Hospital
Kennell, J. H. (1991) · JAMA · doi:10.1001/jama.265.17.2197 · Cited by 473
Stress During Pregnancy Affects General Intellectual and Language Functioning in Human Toddlers
Laplante, D. P., Barr, R. G., Brunet, A., Du Fort, G. G., Meaney, M. L., Saucier, J.-F., Zelazo, P. R., & King, S. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000136281.34035.44 · Cited by 466
Brain anatomy and development in autism: review of structural MRI studies
Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.06.001 · Cited by 418
The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism
Bachevalier, J., & Loveland, K. A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.002 · Cited by 402
A genetic variant that disrupts MET transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401
Antenatal Glucocorticoids and Programming of the Developing CNS
Matthews, S. G. (2000) · Pediatric Research · doi:10.1203/00006450-200003000-00003 · Cited by 400
Prenatal Loss of Father and Psychiatric Disorders
HUTTUNEN, M. O. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770280039004 · Cited by 372
Timing of Prenatal Stressors and Autism
Beversdorf, D. Q., Manning, S. E., Hillier, A. J., Anderson, S. L., Nordgren, R. E., Walters, S., Nagaraja, H. N., Cooley, W. C., Gaelic, S. E., & Bauman, M. L. (2005) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-5037-8 · Cited by 371
The psychological impact of infertility: a comparison with patients with other medical conditions.
Domar, A. D., Zuttermeister, P. C., & Friedman, R. B. (1993) · PubMed · Cited by 353
Autism and Genetics
Smalley, S. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340081013 · Cited by 351
Early communication development and intervention for children with autism
Landa, R. J. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20134 · Cited by 341
Cortisol levels and very early pregnancy loss in humans
Nepomnaschy, P. A., Welch, K. B., McConnell, D. S., Low, B. S., Strassmann, B. I., & England, B. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511183103 · Cited by 335
Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?
Rodriguez, A., & Bohlin, G. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00359.x · Cited by 333
Prenatal stress and cognitive development and temperament in infants
Buitelaar, J. K., Huizink, A. C., Mulder, E. J. H., de Medina, P. R., & Visser, G. H. A. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00050-2 · Cited by 332
The Development of Autism
Burack, J. A., Charman, T., Yirmiya, N., & Zelazo, P. R. (2001) · Routledge eBooks · doi:10.4324/9781410600196 · Cited by 323
Psychological evaluation and support in a program of in vitro fertilization and embryo transfer
Freeman, E. W., Boxer, A. S., Rickels, K., Tureck, R., & Mastroianni, L. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48316-0 · Cited by 319
The effects of prenatal maternal stress on children's cognitive development: Project Ice Storm
King, S., & Laplante, D. P. (2005) · Stress · doi:10.1080/10253890500108391 · Cited by 307
Autism Prevalence Following Prenatal Exposure to Hurricanes and Tropical Storms in Louisiana
Kinney, D. K., Miller, A. M., Crowley, D. J., Huang, E., & Gerber, E. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0414-0 · Cited by 295
Self-citation
Adoptive and Biological Families of Children and Adolescents With ADHD
SPRICH, S., BIEDERMAN, J., CRAWFORD, M. H., MUNDY, E., & FARAONE, S. V. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200011000-00018 · Cited by 291
Autism Spectrum Disorders: Early Detection, Intervention, Education, and Psychopharmacological Management
Bryson, S. E., Rogers, S. J., & Fombonne, E. J. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800802 · Cited by 288
Elevated rates of testosterone-related disorders in women with autism spectrum conditions
Ingudomnukul, E., Baron‐Cohen, S., Wheelwright, S. J., & Knickmeyer, R. C. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.02.001 · Cited by 280
Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability
Schneider, M. L., Roughton, E. C., Koehler, A. J., & Lubach, G. R. (1999) · Child Development · doi:10.1111/1467-8624.00020 · Cited by 267
The impact of prenatal maternal stress and optimistic disposition on birth outcomes in medically high-risk women.
Lobel, M., DeVincent, C. J., Kaminer, A., & Meyer, B. A. (2000) · Health Psychology · doi:10.1037//0278-6133.19.6.544 · Cited by 265
The prevalence and predictability of depression in infertile women
Domar, A. D., Broome, A., Zuttermeister, P. C., Seibel, M. J., & Friedman, R. B. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90662-g · Cited by 260
Cortisol circadian rhythms and response to stress in children with autism
Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.011 · Cited by 258 · cited 1×
“For example, Corbett et al. (2006) found that AD children were more likely than control children to show HPA-axis hyperactivity in response to novel stimuli.”
Background
The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling
(1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.8.1032 · Cited by 255 · cited 2×
“Similar results were obtained by Rodriguez and Bohlin (2005), who prospectively assessed maternal stress at six points during pregnancy using the Swedish 10Kinney et al.”
Result
Prenatal stress increase anxiety related behavior and alters cerebral lateralization of dopamine activity
Fride, E., & Weinstock, M. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90561-9 · Cited by 255
Long‐term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys
Clarke, A. S., Wittwer, D. J., Abbott, D. H., & Schneider, M. L. (1994) · Developmental Psychobiology · doi:10.1002/dev.420270502 · Cited by 245
Mapping corpus callosum deficits in autism: An index of aberrant cortical connectivity
Vidal, C. N., Nicolson, R., DeVito, T. J., Hayashi, K. M., Geaga, J. A., Drost, D. J., Williamson, P. C., Rajakumar, N., Sui, Y., Dutton, R. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.011 · Cited by 244
International Consensus Statement On ADHD
Barkley, R. A. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200212000-00001 · Cited by 242
Glucocorticoid “Programming” and PTSD Risk
SECKL, J. R., & MEANEY, M. J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.027 · Cited by 234
Prenatal, Perinatal, and Neonatal Factors in Autism, Pervasive Developmental Disorder-Not Otherwise Specified, and the General Population
Juul-Dam, N., Townsend, J., & Courchesne, E. (2001) · PEDIATRICS · doi:10.1542/peds.107.4.e63 · Cited by 232
Topical Review: Fetal Testosterone and Sex Differences in Typical Social Development and in Autism
Knickmeyer, R. C., & Baron-Cohen, S. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210101601 · Cited by 230
Prenatal teratogens and the development of adult mental illness
WATSON, J. B., MEDNICK, S. A., HUTTUNEN, M., & WANG, X. (1999) · Development and Psychopathology · doi:10.1017/s0954579499002151 · Cited by 224
Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study
Trautman, P. D., Meyer-Bahlburg, H. F. L., Postelnek, J., & New, M. I. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00070-0 · Cited by 217
Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis
Langley‐Evans, S. C. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715050-00010 · Cited by 216
The Economic Impact of Autism in Britain
Järbrink, K., & Knapp, M. R. J. (2001) · Autism · doi:10.1177/1362361301005001002 · Cited by 212
Prenatal stress effects on functional development of the offspring
Weinstock, M., Fride, E., & Hertzberg, R. (1988) · Progress in brain research · doi:10.1016/s0079-6123(08)60513-0 · Cited by 173
Should fertilization treatment start with reducing stress?
Campagne, D. M. (2006) · Human Reproduction · doi:10.1093/humrep/del078 · Cited by 154
Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex
Mennes, M., Stiers, P. L. J., Lagae, L. G., & den Bergh, B. R. H. V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.04.003 · Cited by 151
Prenatal Stress Depresses Immune Function in Rats
Kay, G., Tarcic, N., Poltyrev, T., & Weinstock, M. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00456-3 · Cited by 149
Etiology of Autism: Genetic Influences
Folstein, S. E., & Piven, J. (1991) · PEDIATRICS · doi:10.1542/peds.87.5.767 · Cited by 147
Repeated doses of antenatal corticosteroids in animals: A systematic review
Aghajafari, F., Murphy, K. E., Matthews, S. G., Ohlsson, A., Amankwah, K., & Hannah, M. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.121624 · Cited by 139
Early childhood psychosis and bleeding during pregnancy
Torrey, E. F., Hersh, S. P., & McCabe, K. D. (1975) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01540676 · Cited by 133
Handedness patterns in autism suggest subtypes
Soper, H. V., Satz, P., Orsini, D. L., Henry, R. R., Zvi, J. C., & SCHULMAN, M. L. (1986) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531727 · Cited by 128
Maternal stress or anxiety in pregnancy and emotional development of the child
Glover, V. A. S. (1997) · The British Journal of Psychiatry · doi:10.1192/bjp.171.2.105 · Cited by 128
Naloxone prevents interruption of parturition and increases plasma oxytocin following environmental disturbance in parturient sows
Lawrence, A. B., Petherick, J. C., McLean, K. A., Gilbert, C. L., Chapman, C., & Russell, J. A. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90371-8 · Cited by 126
Prenatal stress potentiates stress-induced behavior and reduces the propensity to play in juvenile rats
Takahashi, L. K., HAGLIN, C., & Kalin, N. H. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90147-t · Cited by 122
A systems neuroscience approach to autism: Biological, cognitive, and clinical perspectives
Eigsti, I., & Shapiro, T. (2003) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10081 · Cited by 121
Antenatal maternal anxiety is linked with atypical handedness in the child
Glover, V. A. S., O’Connor, T. G., Heron, J., & Golding, J. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2004.04.012 · Cited by 111
Prenatal Stress Alters Seizure Thresholds and the Development of Kindled Seizures in Infant and Adult Rats
Edwards, H. E., Dortok, D., Tam, J., Won, D., & Burnham, W. M. (2002) · Hormones and Behavior · doi:10.1006/hbeh.2002.1839 · Cited by 109
Perinatal complications in adopted and non‐adopted schizophrenics and their controls: Preliminary results
Jacobsen, B., & Kinney, D. K. (1980) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1980.tb07709.x · Cited by 107
Self-citation
Prenatal origins of individual variation in behavior and immunity
Coe, C. L., & Lubach, G. R. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.11.003 · Cited by 106
Urinary cortisol circadian rhythm in a group of high-functioning children with autism
Richdale, A. L., & Prior, M. R. (1992) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01048245 · Cited by 105
The economic consequences of autistic spectrum disorder among children in a Swedish municipality
Järbrink, K. (2007) · Autism · doi:10.1177/1362361307079602 · Cited by 105
Twins and twinning
Hall, J. G. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960122)61:3 · Cited by 103
Prenatal exposure to high levels of glucocorticoids increases the susceptibility of cerebellar granule cells to oxidative stress-induced cell death
Ahlbom, E., Gogvadze, V. G., Chen, M., Celsi, G. E., & Ceccatelli, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260501697 · Cited by 100
Prenatal and Perinatal Factors in the Etiology of Autism
Nelson, K. B. (1991) · PEDIATRICS · doi:10.1542/peds.87.5.761 · Cited by 94
Psychogenic pregnancy disruptions in mammals
de Catanzaro, D., & MacNiven, E. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80050-8 · Cited by 90
Amniotic fluid testosterone: relationship with cortisol and gestational age
Sarkar, P., Bergman, K., Fisk, N. M., O’Connor, T. G., & Glover, V. A. S. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02955.x · Cited by 79
Influence of perinatal factors on the nucleus accumbens dopamine response to repeated stress during adulthood: an electrochemical study in the rat
Brake, W. G., Noel, M. B., Boksa, P., & Gratton, A. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00543-x · Cited by 74
A comparison and analysis of the presence of family problems during pregnancy of mothers of ?autistic? children and mothers of normal children
Ward, A. J. (1990) · Child Psychiatry & Human Development · doi:10.1007/bf00706020 · Cited by 74
Prenatal disturbance alters the size of the corpus callosum in young monkeys
Coe, C. L., Lulbach, G. R., & Schneider, M. L. (2002) · Developmental Psychobiology · doi:10.1002/dev.10063 · Cited by 74
Social withdrawal, neophobia, and stereotyped behavior in developing rats exposed to neonatal asphyxia
Giovanni Laviola, A., Adriani, W., Rea, M., Aloe, L., & Alleva, E. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1800-3 · Cited by 72
Moderate Level Alcohol During Pregnancy, Prenatal Stress, or Both and Limbic-Hypothalamic-Pituitary-Adrenocortical Axis Response to Stress in Rhesus Monkeys
Schneider, M. L., Moore, C. F., & Kraemer, G. W. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00656.x · Cited by 66
A Single Course of Prenatal Betamethasone in the Rat Alters Postnatal Brain Cell Proliferation but not Apoptosis
Scheepens, A., van de Waarenburg, M. P. H., van den Hove, D., & Blanco, C. E. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.043414 · Cited by 65
Hyperactivity and alteration of the midbrain dopaminergic system in maternally stressed male mice offspring
Son, G. H., Chung, S., Geum, D., Kang, S. S., Choi, W. S., Kim, K., & Choi, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.104 · Cited by 62
Maternal gestational stress alters adaptive and social behavior in adolescent rhesus monkey offspring
Clarke, A. S., Soto, A. A., Bergholz, T. M., & Schneider, M. L. (1996) · Infant Behavior and Development · doi:10.1016/s0163-6383(96)90006-5 · Cited by 50
Prenatal Stress Disrupts Reproductive Behavior and Physiology in Offspring
Herrenkohl, L. R. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb28003.x · Cited by 44
Effect of disturbance on labor
Newton, N. R., Peeler, D. F., & Newton, M. (1968) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(68)90355-4 · Cited by 43
Recent advances in companion animal behavior problems
Nicol, C. J. (2000) · Cited by 39
Can the Behaviour Abnormalities Induced by Gestational Stress in Rats be Prevented or Reversed?
Weinstock, M. (2002) · Stress · doi:10.1080/1025389021000010503 · Cited by 37
Induction of microglial apoptosis by corticotropin‐releasing hormone
Ock, J., Lee, H., Kim, S., Lee, W., Choi, D., Park, E. J., Kim, S., Kim, I. K., & Suk, K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03933.x · Cited by 36
Prenatal Stress and Risk for Schizophrenia
Kinney, D. K. (2000) · International Journal of Mental Health · doi:10.1080/00207411.2000.11449503 · Cited by 30
Self-citation
Effects of stress management on testosterone levels in women with early-stage breast cancer
Cruess, D. G., Antoni, M. H., Kumar, M., McGregor, B., Alferi, S. M., Boyers, A. E., Carver, C. S., & Kilbourn, K. M. (2001) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0803_2 · Cited by 24
Human Teratogens: How Can We Sort Them Out?a
Shepard, T. H. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb40325.x · Cited by 13
Infant—Toddler Information Processing Assessment for Children with Pervasive Developmental Disorder and Autism: Part I
Zelazo, P. R. (1997) · Infants & Young Children · doi:10.1097/00001163-199707000-00003 · Cited by 12
The development of the brain and teratogenesis.
Ml, O.-G. (1988) · PubMed · Cited by 3
Psychiatric Genetics in the 21st Century
Bassett, A. S. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600201 · Cited by 3
O-9
Croughan, M. S., Schembri, M. E., Bernstein, D., Chamberlain, N., Purcell, N., & Camarano, L. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.012 · Cited by 2
Untitled work
Sandman (1999) · doi:10.1002/(sici)1098-2302(199904)34:3

Flagged first, then by citations

1 of the 112 references couldn’t be matched to a known paper.

Sorted by citations

The Cerebellum, Sensitive Periods, and Autism
Wang, S. S. ‐., Kloth, A. D., & Badura, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.016 · Cited by 866
Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation
Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-13.2013 · Cited by 814
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662
Prenatal stress and brain development
Charil, A., Laplante, D. P., Vaillancourt, C., & King, S. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.06.002 · Cited by 576

See all 440

Authors: KINNEY, D., MUNIR, K., CROWLEY, D., & MILLER, A.
Affiliations: Harvard University (US)
McLean Hospital (US)
Corresponding author: KINNEY, D
ORCID: CROWLEY, D
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2008-10
Volume: 32
Issue: 8
Pages: 1519-1532
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2008.06.004
PMC: PMC2632594
OpenAlex: W2025653580
Cited by: 440
References: 112
Citations by year: 2026: 7 · 2025: 16 · 2024: 28 · 2023: 19 · 2022: 23 · 2021: 33 · 2020: 28 · 2019: 20 · 2018: 20 · 2017: 35 · 2016: 33 · 2015: 32 · 2014: 28 · 2013: 45 · 2012: 32
FWCI: 6.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH 071286, R25MH071286)
Fogarty International Center (D43TW005807)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords: prenatal stress, autism spectrum disorder, autistic disorder, environmental stressors, life events, schizophrenia, depression, learning deficits, epilepsy, perinatal complications, neuroinflammation, stress tolerance, fetal brain development, gene-environment interaction, autism etiology, prevention
MeSH terms: Autistic Disorder, Female, Humans, Male, Parent-Child Relations, Pregnancy, Prenatal Exposure Delayed Effects, Risk, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prenatal stress and risk for autism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks