The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Caffeine use in children: What we know, what we have left to learn, and why we should worry
Open accessAbstract
Caffeine is a widely used psychoactive substance in both adults and children that is legal, easy to obtain, and socially acceptable to consume. Although once relatively restricted to use among adults, caffeine-containing drinks are now consumed regularly by children. In addition, some caffeine-containing beverages are specifically marketed to children as young as four years of age. Unfortunately, our knowledge of the effects of caffeine use on behavior and physiology of children remains understudied and poorly understood. The purpose of this article is to review what is known about caffeine use in children and adolescents, to discuss why children and adolescents may be particularly vulnerable to the negative effects of caffeine, and to propose how caffeine consumption within this population may potentiate the rewarding properties of other substances. The following topics are reviewed: 1) tolerance and addiction to caffeine 2) sensitization and cross-sensitization to the effects of caffeine 3) caffeine self-administration and reinforcing value and 4) conditioning of preferences for caffeine-containing beverages in both adults and children.
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Citations
Cites
Ferster, C. B., & Skinner, B. F. (1957) · doi:10.1037/10627-000 · Cited by 4,894
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers
Bickel, W. K., Odum, A. L., & Madden, G. J. (1999) · Psychopharmacology · doi:10.1007/pl00005490 · Cited by 1,433
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Coffee and Health: A Review of Recent Human Research
Higdon, J. V., & Frei, B. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390500400009 · Cited by 1,090 · cited 1×
“These topics have been reviewed recently and, thus, will only be discussed briefly here (Higdon and Frei, 2006; Nawrot et al., 2003).”
Caffeinated energy drinks a growing problem
Reissig, C. J., Strain, E. C., & Griffiths, R. R. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.08.001 · Cited by 1,026
A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
Hernán, M. A., Takkouche, B., Caamaño‐Isorna, F., & Gestal‐Otero, J. J. (2002) · Annals of Neurology · doi:10.1002/ana.10277 · Cited by 818 · cited 1×
“Finally, there is some evidence of an inverse relationship between caffeine consumption and colorectal cancer (Giovannucci, 1998; Tavani and La Vecchia, 2004) and Parkinson’s disease (Hernan et al., 2002; Ross et al., 2000), but the mechanisms for this apparent protection remain unknown.”
Association of coffee and caffeine intake with the risk of Parkinson disease
Ross, G. W. (2000) · JAMA · doi:10.1001/jama.283.20.2674 · Cited by 778
Effects of caffeine on human behavior
Smith, A. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00096-0 · Cited by 741
Cited by
Health effects of energy drinks on children, adolescents, and young adults
Seifert, S. M., Schaechter, J. L., Hershorin, E. R., & Lipshultz, S. E. (2011) · Pediatrics · doi:10.1542/peds.2009-3592 · Cited by 893
Caffeine as a factor influencing the functioning of the human body-friend or foe?
Rodak, K., Kokot, I., & Kratz, E. M. (2021) · Nutrients · doi:10.3390/nu13093088 · Cited by 188
Wong, M. M., Brower, K. J., Nigg, J. T., & Zucker, R. A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01178.x · Cited by 161
Trends in Caffeine Intake Among US Children and Adolescents
Branum, A. M., Rossen, L. M., & Schoendorf, K. C. (2014) · Pediatrics · doi:10.1542/peds.2013-2877 · Cited by 151
Al-Shaar, L., Vercammen, K., Lu, C., Richardson, S., Tamez, M., & Mattei, J. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00225 · Cited by 136
“While moderate caffeine intake (up to 400 mg/day) is generally considered safe and even beneficial for health among adults (11), there has not been extensive research conducted on children and adolescents to determine if any tolerable level exists (12).”
Background
Metadata
- Authors
- Temple, J. L.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 33
- Issue
- 6
- Pages
- 793-806
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2010158637
- Cited by
- 326
- References
- 46
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Temple, J. L. (2009). Caffeine use in children: What we know, what we have left to learn, and why we should worry. Neuroscience & Biobehavioral Reviews. https://doi.org/10.1016/j.neubiorev.2009.01.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.