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Restraint stress in biobehavioral research: Recent developments
Abstract
In the 15 years since the publication of two previous reviews on restraint stress much advancement has been made in the field. However, while previous reviews have focused mainly on drug effects, recent research has focused on broader implications in the health fields. This research has placed an increased emphasis on stress effects in physiological, immunological, endocrine and developmental processes as well as the impact of stress on numerous disorders. A major problem with our review was the inability to identify a large number of articles focusing on restraint and immobilization, since those keywords were often omitted from the title or not referred to within the body of the article. It seems likely that additional reviews with extended literature research of this field are required.
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“The CRS model ideally mimics the key features of this type of stressor and has been used as a major experimental model of depression [28, 29].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [28]
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“The naïve control group was included as a potential control for stress induced by gavage, because prenatal stress can alter later behaviors (reviewed in Buynitsky and Mostofsky, 2009;Maccari and Morley-Fletcher, 2007;Weinstock, 2001).”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Buynitsky and Mostofsky, 2009
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Metadata
- Authors
- Buynitsky, T., & Mostofsky, D. I.
- Affiliations
- Boston University (US)
- Corresponding author
- Mostofsky, David I.
- ORCID
- Mostofsky, David I.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 33
- Issue
- 7
- Pages
- 1089-1098
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1985240984
- Cited by
- 426
- References
- 136
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 36 · 2023: 22 · 2022: 33 · 2021: 24 · 2020: 27 · 2019: 32 · 2018: 23 · 2017: 23 · 2016: 33 · 2015: 22 · 2014: 36 · 2013: 23 · 2012: 20
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- restraint stress, stress and disease, animal models of stress
- MeSH terms
- Alzheimer Disease, Animals, Autonomic Nervous System, Endocrine System, Female, Humans, Infections, Inflammation, Male, Pain, Pregnancy, Prenatal Exposure Delayed Effects, Restraint, Physical, Sex Characteristics, Stress, Psychological, Time Factors, Wound Healing
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