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Restraint stress in biobehavioral research: Recent developments
Abstract
In the 15 years since the publication of two previous reviews on restraint stress much advancement has been made in the field. However, while previous reviews have focused mainly on drug effects, recent research has focused on broader implications in the health fields. This research has placed an increased emphasis on stress effects in physiological, immunological, endocrine and developmental processes as well as the impact of stress on numerous disorders. A major problem with our review was the inability to identify a large number of articles focusing on restraint and immobilization, since those keywords were often omitted from the title or not referred to within the body of the article. It seems likely that additional reviews with extended literature research of this field are required.
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“The CRS model ideally mimics the key features of this type of stressor and has been used as a major experimental model of depression [28, 29].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [28]
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“The naïve control group was included as a potential control for stress induced by gavage, because prenatal stress can alter later behaviors (reviewed in Buynitsky and Mostofsky, 2009;Maccari and Morley-Fletcher, 2007;Weinstock, 2001).”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Buynitsky and Mostofsky, 2009
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Restraint Stress Reduces the Antitumor Efficacy of Cyclophosphamide in Tumor-Bearing Mice
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Restraint alters the thermic response to morphine by postural interference
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Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing
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Early exposure to restraint stress enhances chemical carcinogenesis in rat liver
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Behavioral Effects of Aluminum in Mice: Influence of Restraint Stress
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Stress may enhance nicotine effects on periodontal tissues. An in vivo study in rats
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The effect of stress on the antioxidative potential of serum: implications for Alzheimer’s disease
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Restraint stress alters lung gene expression in an experimental influenza A viral infection
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Behavioral and Adaptive Status in an Experimental Model of Alzheimer's Disease in Rats
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EFFECT OF IMMOBILIZATION AND COLD STRESS ON VISUAL EVOKED POTENTIALS
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Psychological stress and wound healing: Kiecolt-Glaser et al. (1995).
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Repeated immobilization stress in the early postnatal period increases stress response in adult rats
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NMU-induced mammary carcinogenesis in female rats is influenced by repeated psychoemotional stress.
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A suppressive protein generated in peripheral lymph tissue induced by restraint stress
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Self-citationStress, inflammatory markers and factors associated in patients with type 2 diabetes mellitus
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Rat Strain and Sex Differences in Leptin Responses to Immobilization Stress
Ceballos, R. M., Faraday, M. M., & Klein, L. C. (2006) · Journal of Individual Differences · doi:10.1027/1614-0001.27.3.136 · Cited by 6
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Metadata
- Authors
- Buynitsky, T., & Mostofsky, D. I.
- Affiliations
- Boston University (US)
- Corresponding author
- Mostofsky, David I.
- ORCID
- Mostofsky, David I.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 33
- Issue
- 7
- Pages
- 1089-1098
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1985240984
- Cited by
- 426
- References
- 136
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 36 · 2023: 22 · 2022: 33 · 2021: 24 · 2020: 27 · 2019: 32 · 2018: 23 · 2017: 23 · 2016: 33 · 2015: 22 · 2014: 36 · 2013: 23 · 2012: 20
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- restraint stress, stress and disease, animal models of stress
- MeSH terms
- Alzheimer Disease, Animals, Autonomic Nervous System, Endocrine System, Female, Humans, Infections, Inflammation, Male, Pain, Pregnancy, Prenatal Exposure Delayed Effects, Restraint, Physical, Sex Characteristics, Stress, Psychological, Time Factors, Wound Healing
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