Cited by 454Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Brain reward circuitry beyond the mesolimbic dopamine system: A neurobiological theory

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Ikemoto, Satoshi·2010·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2010.02.001PMC PMC2894302

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Abstract

Reductionist attempts to dissect complex mechanisms into simpler elements are necessary, but not sufficient for understanding how biological properties like reward emerge out of neuronal activity. Recent studies on intracranial self-administration of neurochemicals (drugs) found that rats learn to self-administer various drugs into the mesolimbic dopamine structures-the posterior ventral tegmental area, medial shell nucleus accumbens and medial olfactory tubercle. In addition, studies found roles of non-dopaminergic mechanisms of the supramammillary, rostromedial tegmental and midbrain raphe nuclei in reward. To explain intracranial self-administration and related effects of various drug manipulations, I outlined a neurobiological theory claiming that there is an intrinsic central process that coordinates various selective functions (including perceptual, visceral, and reinforcement processes) into a global function of approach. Further, this coordinating process for approach arises from interactions between brain structures including those structures mentioned above and their closely linked regions: the medial prefrontal cortex, septal area, ventral pallidum, bed nucleus of stria terminalis, preoptic area, lateral hypothalamic areas, lateral habenula, periaqueductal gray, laterodorsal tegmental nucleus and parabrachical area.

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Items 201–277 of 277

The central extended amygdala network as a proposed circuit underlying reward valuation
Waraczynski, M. A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.09.001 · Cited by 78
The Anatomical Locus of Reinforcement
Valenstein, E. S. (1966) · NASA Technical Reports Server (NASA) · Cited by 76
Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists
Shippenberg, T. S., Bals-Kubik, R., Huber, A., & Herz, A. (1991) · Psychopharmacology · doi:10.1007/bf02244205 · Cited by 74
Conditioned place preference induced by microinjection of 8-OH-DPAT into the dorsal or median raphe nucleus
Fletcher, P. J., Ming, Z.-H., & Higgins, G. A. (1993) · Psychopharmacology · doi:10.1007/bf02244330 · Cited by 74
Cell cycle kinetics in the embryonic mouse corpus striatum
Bhide, P. G. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961028)374:4 · Cited by 73
Dual Role of Medial A10 Dopamine Neurons in Affective Encoding
Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73
Self-citation
The effect of food and water deprivation upon intracranial self-stimulation.
Brady, J. V., Boren, J. J., Conrad, D. G., et al. (1957) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0045231 · Cited by 72
Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons
Rodd, Z. A., Bell, R. L., Kuc, K. A., Zhang, Y., Murphy, J. M., & McBride, W. J. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.075952 · Cited by 72
Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat
Kinney, G. G., Kocsis, B., & Vertes, R. P. (1995) · Psychopharmacology · doi:10.1007/bf02311170 · Cited by 70
A motivational analyses of the reticular activating system
Olds, J., & Peretz, B. (1960) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(60)90020-1 · Cited by 68
The Reinforcing Properties of Salsolinol in the Ventral Tegmental Area: Evidence for Regional Heterogeneity and the Involvement of Serotonin and Dopamine
Rodd, Z. A., Oster, S. M., Ding, Z., Toalston, J. E., Deehan, G. A., Bell, R. L., Li, T., & McBride, W. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00572.x · Cited by 68
Afferents to the midline thalamus issue collaterals to the nucleus tractus solitarii: an anatomical basis for thalamic and visceral reflex integration
Otake, K., Dj, R., & Ruggiero, D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05694.1994 · Cited by 67
Two substrates for medial forebrain bundle self-stimulation: Myelinated axons and dopamine axons
Yeomans, J. S. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80016-8 · Cited by 67
Rewarding brain stimulation induces only sparse Fos-like immunoreactivity in dopaminergic neurons
Hunt, G. E., & McGregor, I. S. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00409-0 · Cited by 66
Effect of lesions in the central nervous system on lateral hypothalamic self-stimulation in the rat.
Lorens, S. A. (1966) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0023658 · Cited by 65
Mesolimbic dopamine and its control of locomotor activity in rats: differences in pharmacology and light/dark periodicity between the olfactory tubercle and the nucleus accumbens
Cools, A. R. (1986) · Psychopharmacology · doi:10.1007/bf00178506 · Cited by 62
Studies on the behavioral activation produced by stimulation of GABAB receptors in the median raphe nucleus
Wirtshafter, D., Stratford, T. R., & Pitzer, M. R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90154-i · Cited by 61
Brain stem afferents to the rat medial septum.
Segal, M. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011577 · Cited by 61
Median raphe injections of 8-OH-DPAT lower frequency thresholds for lateral hypothalamic self-stimulation
Fletcher, P., Tampakeras, M., & Yeomans, J. S. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00441-k · Cited by 58
Injections of excitatory amino acid antagonists into the median raphe nucleus produce hippocampal theta rhythm in the urethane-anesthetized rat
Kinney, G. G., Kocsis, B., & Vertes, R. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91575-x · Cited by 58
Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat
Hayakawa, T., Ito, H., & Zyo, K. (1993) · Anatomy and Embryology · doi:10.1007/bf00186247 · Cited by 57
Rewarding Effects of AMPA Administration into the Supramammillary or Posterior Hypothalamic Nuclei But Not the Ventral Tegmental Area
Ikemoto, S., Witkin, B. M., Zangen, A., & Wise, R. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5367-04.2004 · Cited by 56
Self-citation
Septohippocampal properties of N ‐methyl‐ D ‐aspartate‐induced theta‐band oscillation and synchrony
Bland, B. H., Declerck, S., Jackson, J., Glasgow, S. D., & Oddie, S. (2006) · Synapse · doi:10.1002/syn.20357 · Cited by 56
Conditioned responses in rats reinforced by light
Hurwitz, H. M. B. (1956) · The British Journal of Animal Behaviour · doi:10.1016/s0950-5601(56)80013-0 · Cited by 55
The role of the olfactory tubercle in the effects of cocaine, morphine and brain-stimulation reward
Kornetsky, C. H., Huston-Lyons, D., & Porrino, L. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91076-d · Cited by 53
Self-administration of morphine into the lateral hypothalamus in the mouse
Cazala, P., Darracq, C., & Saint-Marc, M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90908-5 · Cited by 52
Laminar and cellular distribution of AMPA, kainate, and NMDA receptor subunits in monkey sensory-motor cortex
Mu�oz, A., Woods, T. M., & Jones, E. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990517)407:4 · Cited by 52
The sites of origin of dopaminergic afferent fibers to the lateral habenular nucleus in the rat
Li, Y., Takada, M., Shinonaga, Y., & Mizuno, N. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330110 · Cited by 50
Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle
Shin, R. S., Qin, M., Liu, Z., & Ikemoto, S. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1131-x · Cited by 47
Self-citation
The relationship between self-stimulation and sniffing in rats: does a common brain system mediate these behaviors?
Ikemoto, S., & Panksepp, J. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90155-4 · Cited by 46
Self-citation
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Flores, C., Arvanitogiannis, A., & Shizgal, P. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)02288-2 · Cited by 44
Self-administration of the GABA A antagonist bicuculline into the ventral tegmental area in mice: dependence on D 2 dopaminergic mechanisms
David, V., Durkin, T., & Cazala, P. (1997) · Psychopharmacology · doi:10.1007/s002130050214 · Cited by 43
The Supramammillary Nucleus Mediates Primary Reinforcement via GABAA Receptors
Ikemoto, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300660 · Cited by 43
Self-citation
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Rodd, Z. A., Gryszowka, V. E., Toalston, J. E., Oster, S. M., Ji, D., Bell, R. L., & McBride, W. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112607 · Cited by 43
The midbrain raphe nuclei mediate primary reinforcement via GABAA receptors
Liu, Z., & Ikemoto, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05319.x · Cited by 42
Self-citation
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Arvanitogiannis, A., Flores, C., & Shizgal, P. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00065-x · Cited by 42
Increased ipsilateral expression of Fos following lateral hypothalamic self-stimulation
Arvanitogiannis, A., Flores, C., Pfaus, J. G., & Shizgal, P. (1996) · Brain Research · doi:10.1016/0006-8993(96)00096-0 · Cited by 42
Organization of the basal forebrain projection to the thalamus in rats
Kolmac, C. I., & Mitrofanis, J. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00614-x · Cited by 41
Evidence against serotonin involvement in the hyperactivity produced by injections of muscimol into the median raphe nucleus
Wirtshafter, D., Klitenick, M. A., & Asin, K. E. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90475-8 · Cited by 39
Projections from the medial septum and diagonal band of Broca to the dorsal and central superior raphe nuclei: a non-cholinergic pathway
Kal�n, P., & Wiklund, L. (1989) · Experimental Brain Research · doi:10.1007/bf00247947 · Cited by 37
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Judge, S. J., Ingram, C. D., & Gartside, S. E. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.05.003 · Cited by 36
Toward a cellular analysis of intracranial self-stimulation: Contributions of collision studies
Shizgal, P. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80015-6 · Cited by 36
Self-stimulation of the olfactory bulb
Phillips, A. G., & Mogenson, G. J. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90080-8 · Cited by 35
Amphetamine Administration into the Ventral Striatum Facilitates Behavioral Interaction with Unconditioned Visual Signals in Rats
Shin, R. S., Cao, J., Webb, S. M., & Ikemoto, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008741 · Cited by 35
Self-citation
Effects of intracranial self-stimulation on selected physiological variables in rats
Burgess, M. L., Davis, J. M., Wilson, S. P., Borg, T. K., Burgess, W. A., & Buggy, J. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.1.r149 · Cited by 34
Microinjections of dopamine agonists and cocaine elevate plasma corticosterone: dissociation effects among the ventral and dorsal striatum and medial prefrontal cortex
Ikemoto, S., & Goeders, N. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01070-1 · Cited by 34
Self-citation
Differentiation of intracranial morphine self-administration behavior among five brain regions in mice
David, V., & Cazala, P. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90324-7 · Cited by 34
Intra-median raphe infusions of muscimol and the substance P analogue DiMe-C7 produce hyperactivity: role of serotonin neurons
PARIS, J., & Lorens, S. A. (1987) · Behavioural Brain Research · doi:10.1016/0166-4328(87)90162-8 · Cited by 33
Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus
Shim, I., Javaid, J. I., & Wirtshafter, D. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00060-0 · Cited by 32
Localization of reward-relevant neurons in the pontine tegmentum: a moveable electrode mapping study
Rompré, P.-P., & Boye, S. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91076-7 · Cited by 32
Motivation as central organizing process: the psychophysical approach to its functional and neurophysiological analysis.
Gallistel, C. R. (1975) · PubMed · Cited by 32
The effects of excitotoxin lesions of the lateral hypothalamus on self-stimulation reward
Stellar, J. R., Hall, F. S., & Waraczynski, M. A. (1991) · Brain Research · doi:10.1016/0006-8993(91)91070-h · Cited by 31
Rewarding injections of the cholinergic agonist carbachol into the ventral tegmental area induce locomotion and c-Fos expression in the retrosplenial area and supramammillary nucleus
Ikemoto, S., Witkin, B. M., & Morales, M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02280-7 · Cited by 30
Self-citation
A GABAergic mechanism in the medial septum influences cortical arousal and locomotor activity but not a previously learned spatial discrimination task
Osborne, P. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90150-3 · Cited by 30
Pressor responses to electrical and chemical stimulation of the rat brain A10 dopaminergic system
Cornish, J. L., & van den Buuse, M. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90068-x · Cited by 30
Analysis of the relationships between self-stimulation sniffing and brain-stimulation sniffing
Rossi, J., & Panksepp, J. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90119-m · Cited by 29
N-Methyl-d-aspartic acid-induced lesions of the nucleus accumbens and/or ventral pallidum fail to attenuate lateral hypothalamic self-stimulation reward
Johnson, P. I., & Stellar, J. R. (1994) · Brain Research · doi:10.1016/0006-8993(94)90059-0 · Cited by 29
Reinforcing Brain Stimulation in Competition with Water Reward and Shock Avoidance
Valenstein, E. S., & Beer, B. (1962) · Science · doi:10.1126/science.137.3535.1052 · Cited by 27
Effects of knife-cut lesions of the medial forebrain bundle in self-stimulating rats.
Janas, J. D., & Stellar, J. R. (1987) · Behavioral Neuroscience · doi:10.1037//0735-7044.101.6.832 · Cited by 27
Studies in Light-Reinforced Behaviour III. the Effect of Continuous, Zero and Fixed-Ratio Reinforcement
Stewart, J., & Hurwitz, H. M. B. (1958) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470215808416254 · Cited by 24
Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression
Shin, R. S., & Ikemoto, S. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-101 · Cited by 24
Self-citation
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Shin, R. S., & Ikemoto, S. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1757-3 · Cited by 24
Self-citation
Destruction of the medial forebrain bundle caudal to the site of stimulation reduces rewarding efficacy but destruction rostrally does not.
Gallistel, C. R., Leon, M., Lim, B. T., et al. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.766 · Cited by 22
6-Hydroxydopamine lesions of the olfactory tubercle do not alter (+)-amphetamine-conditioned place preference
Clarke, P. B. S., White, N. M., & Franklin, K. B. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90173-c · Cited by 21
Nicotinic receptor mechanism in supramammillary nucleus mediates physiological regulation of neural activity in dorsal hippocampal field CA1 of anaesthetized rat
Ariffin, M. Z., Jiang, F., Low, C., & Khanna, S. (2009) · Hippocampus · doi:10.1002/hipo.20687 · Cited by 20
Self-administration of the GABAA agonist muscimol into the medial septum: dependence on dopaminergic mechanisms
Gavello-Baudy, S., Merrer, J. L., Decorte, L., David, V., & Cazala, P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1263-z · Cited by 19
Intense vasoconstriction and bradycardia evoked by stimulation of neurones within the midbrain ventral tegmentum of the rabbit
Tan, E., Goodchild, A. K., & Dampney, R. A. L. (1983) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1983.tb00202.x · Cited by 19
Differential involvement of the lateral and medial divisions of the septal area on spatial learning processes as revealed by intracranial self-administration of morphine in mice
Cazala, P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00040-0 · Cited by 19
Ventral midbrain stimulation, blood pressure responses and their relation to the dopaminergic nigro-striatal pathways
Spring, A., & Winkelm�ller, W. (1975) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580531 · Cited by 17
A five-minute, but not a fifteen-minute, conditioning trial duration induces conditioned place preference for cocaine administration into the olfactory tubercle
Ikemoto, S., & Donahue, K. M. (2005) · Synapse · doi:10.1002/syn.20124 · Cited by 17
Self-citation
Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon
Marcangione, C., & Rompré, P.-P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.014 · Cited by 16
Hippocampal theta rhythm in anesthetized rats
Puma, C., & Bizot, J. (1999) · Neuroreport · doi:10.1097/00001756-199908020-00014 · Cited by 16
Nonserotonergic control of nucleus accumbens dopamine metabolism by the median raphe nucleus
Wirthshafter, D., & Trifunovic, R. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90364-l · Cited by 12
Behavioral function of GABA in the median raphe nucleus.
Fink, H., & Morgenstern, R. (1986) · PubMed · Cited by 7
6-OHDA-treated weanling rats show normal neuroleptic sensitivity as adults on LHSS
Sidhu, K. S., Stellar, J. R., Garity, D., et al. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90022-l · Cited by 3
Muscimol injections into the median raphe nucleus increase serum ACTH and corticosterone concentrations via a nonserotonergic mechanism
Paris, J. M., Lorens, S. A., Lee, J. M., et al. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90161-t · Cited by 3
Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: a histoautoradiographic study
Veinante, P., & Freund-Mercier, M.-J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970707)383:3

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Authors: Ikemoto, S.
Affiliations: National Institutes of Health (US)
Corresponding author: Ikemoto, Satoshi
ORCID: Ikemoto, Satoshi
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2010-11
Volume: 35
Issue: 2
Pages: 129-150
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2010.02.001
PMC: PMC2894302
OpenAlex: W2026626196
Cited by: 454
References: 277
Citations by year: 2026: 20 · 2025: 20 · 2024: 26 · 2023: 22 · 2022: 39 · 2021: 33 · 2020: 35 · 2019: 31 · 2018: 24 · 2017: 13 · 2016: 23 · 2015: 31 · 2014: 33 · 2013: 35 · 2012: 32
FWCI: 13.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (ZIADA000480, Z01DA000439, ZIADA000439)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: brain reward system, mesolimbic dopamine system, drug reward, supramammillary nucleus, rostromedial tegmental nucleus, midbrain raphe nuclei, approach behavior, reinforcement, medial prefrontal cortex, septal area, ventral pallidum, bed nucleus of the stria terminalis, preoptic area, lateral hypothalamus, lateral habenula, periaqueductal gray, laterodorsal tegmental nucleus, parabrachial area
MeSH terms: Animals, Brain, Dopamine, Models, Neurological, Neural Pathways, Reward, Self Administration

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Brain reward circuitry beyond the mesolimbic dopamine system: A neurobiological theory

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