The DOI matches its Crossref record; 351 of the 357 references it cites were found in a registry or an index.
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Open accessAbstract
Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. Given substantial preclinical evidence that DA is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. Moreover, bridging the gap between preclinical and clinical models of anhedonia may require moving away from the conceptualization of anhedonia as a steady-state, mood-like phenomena. Consequently, we introduce the term "decisional anhedonia" to address the influence of anhedonia on reward decision-making. These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Anhedonia and impaired reward circuit pathways are associated with a poorer prognosis and suboptimal treatment response (Buckner et al., 2008;Uher et al., 2012;Treadway and Zald, 2011).”
From Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment (2021) · cites this paper as Treadway and Zald, 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“co-morbid traits, such as depression, anxiety, or inattention/hyperactivity, are often associated with ASD [212], and are known to affect general reward processing [213,214] and intervention response [215].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [213]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“studies of the neurobiology of reward processing have highlighted the variety of distinct pathways involved in its different aspects resulting in the recognition of separate subtypes of anhedonia, including consummatory, anticipatory, motivational and decisional [20,21].”
From Prefrontal cortex and depression (2022) · cites this paper as [20]
Experimental — accuracy not yet measuredIn the citing paper
“Anhedonia is a broad construct that includes deficits in anticipation of, motivation toward, and responsiveness to reward, as well as deficits in reward learning (ability to recall and make decisions based on past rewarding experiences) (Treadway and Zald, 2011) and is estimated to be 46% heritable in studies of monozygotic twins (Bogdan and Pizzagalli, 2009).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“hyposensitivity to reward and hypersensitivity to punishment have been a consistent finding in depression”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Treadway and Zald 2011
In the citing paper
“Dysregulation of dopamine release in motivating responses to rewarding and aversive stimuli, as well as cognitive demand, is a plausible mechanistic cause that can explain a range of depression symptoms [24][25][26][27][28][29].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [25]
In the citing paper
“Particularly relevant in the present context are previous reports [290,296,297] that although both DA and non-DA agents can be used to effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia, specifically when compared with non-DA agents [19,298-300].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“The mesolimbic DA system represents only one component of a very complex and integrated set of circuits, and although DA is clearly a crucial neurotransmitter in the reward-processing system, non-DA systems clearly also modulate reward responsibility [19,735].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“Additionally, multiple non-DA compounds have shown efficacy in improving reward responses, such as agents that affect glutamate circuits involved in regulating monoamine systems [19].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“However, recent studies suggest that many patients with schizophrenia or Parkinson’s, and possibly some with major depression, are not actually anhedonic after all: they report normal sensory pleasure ratings of ice cream or other sensory reward in the moment, even though they attach little value to any sensory, social or other pleasant reward in life.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“Some investigators therefore have suggested their deficit really reflects a selective loss of incentive motivation or ‘wanting,’ rather than loss of pleasure ‘liking’ (Sienkiewicz-Jarosz et al., 2005; Dowd and Barch, 2010; Treadway and Zald, 2011; Barch et al., 2014).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“Anhedonia typically does not respond to first-line pharmacotherapies [5, 7, 8]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1×
“Introduction With a lifetime prevalence of approximately 16% (Kessler et al., 2003), Major Depressive Disorder (MDD) is predicted to become the second leading cause of death and disability in the United States by the year 2020 (Murray and Lopez, 1997).”
BackgroundGray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Research works printed but not linked: 1
- Schoenbaum, 2003, A systems approach to orbitofrontal cortex reveal interactions with different learning systems, 146, 19
Cited by
Sorted by citations
Items 901–1,000 of 1,001
Studying the social mind: An updated summary of findings from the Vietnam Head Injury Study
Cristofori, I., Cohen‐Zimerman, S., Krüeger, F., Kermani, R. J. N., Delikishkina, E., Gordon, B., Beuriat, P.-A., & Grafman, J. H. (2024) · Cortex · doi:10.1016/j.cortex.2024.03.002 · Cited by 10
Olivola, M., Mazzoni, F., Tarantino, B., Guffanti, A., Marcatili, M., Motta, F. L., Cornaggia, R. D., Martiadis, V., Prodi, T., Politi, P., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120231 · Cited by 9
The ARCH model: a neuroevolutionary framework for behavioral execution
Rahman, T., Zorumski, C. F., & Meloy, J. R. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1669530 · Cited by 10
Predictive processing accounts of psychosis: bottom-up or top-down disruptions
Goodwin, I., Diederen, K. M. J., Hird, E., Weilnhammer, V. A., Garrido, M. I., & Knolle, F. (2026) · Nature Mental Health · doi:10.1038/s44220-025-00558-5 · Cited by 9
Depression deconstruction lessons from psychosomatic research
de Jonge, P. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.12.013 · Cited by 9
Simon, P. D. (2016) · Psychological Studies · doi:10.1007/s12646-016-0377-3 · Cited by 10
Scheggi, S., Pelliccia, T., Cuomo, A., Montis, M. G. D., & Gambarana, C. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00849 · Cited by 9
Goldstein‐Piekarski, A. N., & Williams, L. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00021-4 · Cited by 10
Rodríguez, M. G., Alvarado, J. M., Rodríguez, V. J., & Iotova, A. I. (2021) · Studies in Psychology Estudios de Psicología · doi:10.1080/02109395.2020.1857632 · Cited by 13
Xiao, W., Zhu, R., Lv, Z., Fan, J., Yi, Z., Chen, J., Ju, K., & Yan, C. (2022) · PsyCh Journal · doi:10.1002/pchj.517 · Cited by 9
Yu, Q., Wang, X., Cao, Y., Lu, J., Gao, F., Fan, J., & Zhu, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.039 · Cited by 9
Schaub, A.-C., Vogel, M., Lang, U. E., Kaiser, S., Walter, M., Herdener, M., Wrege, J. S., Kirschner, M., & Schmidt, A. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103423 · Cited by 9
Chu, M., Li, S., Wang, Y., Lui, S. S. Y., & Chan, R. C. K. (2023) · PsyCh Journal · doi:10.1002/pchj.723 · Cited by 9
Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins
Lee, T. H., Nicolas, J.-C., & Quarta, C. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02411-5 · Cited by 12
Patel, K. K., Kearns, J. C., Foti, D., Pigeon, W. R., Kleiman, E. M., & Glenn, C. R. (2024) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-024-01275-w · Cited by 11
Restoration of positive mood states in major depression as a potential drug development target
Lane, R. M. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114532857 · Cited by 9
Macdonald, B., Murray, L., Moutsiana, C., Fearon, P. R. M., Cooper, P., Halligan, S. L., & Johnstone, T. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.05.006 · Cited by 8
Heritage, A. J., Long, L. J., Woodman, G. F., & Zald, D. H. (2017) · Psychophysiology · doi:10.1111/psyp.12987 · Cited by 9
Self-citationGriesius, S., Mellor, J. R., & Robinson, E. S. J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05541-9 · Cited by 9
Harris, E. P., McGovern, A. J., Melo, T. G., Barron, A., Nolan, Y. M., & O’Leary, O. F. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113725 · Cited by 10
Effects of chronic psychosocial stress on ‘binge-like’ sucrose intake in mice
Bahí, A., & Dreyer, J. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110625 · Cited by 9
Anhedonia and sensitivity to punishment in schizophrenia, depression and opiate use disorder
Ossola, P., Garrett, N., Biso, L., Bishara, A. J., & Marchesi, C. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.120 · Cited by 10
Contemporary perspectives on effort: A special issue
Richter, M. M., & Wright, R. A. (2014) · Motivation and Emotion · doi:10.1007/s11031-014-9435-0 · Cited by 10
Pramipexole and Electroconvulsive Therapy in Treatment-Resistant Depression
Gauthier, C., Souaiby, L., Advenier-Iakovlev, E., & Raphaël Gaillard, B. (2017) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000253 · Cited by 9
Ito, M., Miyamae, M., Yokoyama, C., Yamashita, Y., Ueno, O., Maruo, K., Komazawa, A., Niwa, M., Honda, M., & Horikoshi, M. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.15819 · Cited by 10
Hartmann, J. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150114jh · Cited by 9
Specific mechanisms underlying executive and emotional apathy: A phenotyping study
Lafond-Brina, G., Pham, B., & Bonnefond, A. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.02.022 · Cited by 9
Demaili, A., Portugalov, A., Maroun, M., Akirav, I., Braun, K., & Bock, J. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1474992 · Cited by 8
McIntyre, R. S., Llorca, P., Aronin, L. C., Yu, J., & Nguyen, H. (2024) · Advances in Therapy · doi:10.1007/s12325-024-03009-2 · Cited by 8
Emotions and individual differences shape human foraging under threat
Trier, H. A., O’Reilly, J. X., Spiering, L., Yishan, S. M., Kolling, N., Rushworth, M. F. S., & Scholl, J. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00393-8 · Cited by 10
Mu, Q., Wu, C., Chen, Y., Xu, Y., Zhang, K., Zhu, C., Hu, S., Huang, M., Zhang, P., Cui, D., et al. (2025) · Depression and Anxiety · doi:10.1155/da/1925158 · Cited by 8
McIntyre, R. S., Maletic, V., Masand, P. S., Wilson, A. C., Yu, J., Adams, J. L., & Kerolous, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.05.026 · Cited by 10
Zhang, Y., Yang, L., Zhang, Q., Li, C., Mao, F., & Zhuo, C. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03410-7 · Cited by 9
Developing Clinically Interpretable Neuroimaging Biotypes in Psychiatry
Ahn, J., Foland‐Ross, L. C., Akiki, T. J., Boyar, L., Wydler, I., Bostian, C. M., Zhang, X., Yang, H., Ellsay, A., Ma, E. W., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.08.019 · Cited by 11
How Does It “Feel”? A Signal Detection Approach to Feeling Generation
Karmon-Presser, A., Sheppes, G., & Meiran, N. (2018) · Emotion · doi:10.1037/emo0000298 · Cited by 10
Wu, Q., He, J., Fang, S., Zhang, P., Luo, X., Zhang, J., Xiong, Y., Luo, F., Wang, X., Yao, S., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02900-w · Cited by 8
Factorial Validity and Invariance of an Adolescent Depression Symptom Screening Tool
Long, A., DeFreese, J. D., Bickett, A. K., & Price, D. (2021) · Journal of Athletic Training · doi:10.4085/1062-6050-343-21 · Cited by 8
Jenness, J. L., DeLonga, K., Lewandowski, R. E., Spiro, C. N., Crowe, K., Martell, C. R., Towbin, K. E., Stringaris, A. K., & McCauley, E. (2022) · Evidence-Based Practice in Child and Adolescent Mental Health · doi:10.1080/23794925.2022.2042871 · Cited by 8
Anhedonia in endometriosis: An unexplored symptom
Mallorquí, A., Martínez‐Zamora, M. Á., & Carmona, F. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.935349 · Cited by 8
Do cognitive and physical effort costs affect choice behavior similarly?
Lim, L. X., Fansher, M., & Hélie, S. (2022) · Journal of Mathematical Psychology · doi:10.1016/j.jmp.2022.102727 · Cited by 10
Han, S., Zheng, R., Li, S., Zhou, B., Jiang, Y. B., Fang, K., Wei, Y., Wen, B., Pang, J., Li, H., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.159 · Cited by 8
Lindahl, J., Asp, M., Ståhl, D., Tjernberg, J., Eklund, M., Björkstrand, J., van Westen, D., Jensen, J., Månsson, K. N. T., Tornberg, Å. B., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076900 · Cited by 8
Brendler, A., Schneider, M., Elbau, I., Sun, R., Nantawisarakul, T., Pöhlchen, D., Brückl, T. M., BeCOME Working Group, Brem, A., Binder, E. B., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-48792-0 · Cited by 11
An Examination of the Multi-Faceted Motivation System in Healthy Young Adults
Silva, S. D., Apatsidou, A., Saperia, S., Siddiqui, I., Jeffay, E., Voineskos, A. N., Daskalakis, Z. J., Remington, G. J., Zakzanis, K. K., & Foussias, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00191 · Cited by 10
Cuthbert, B. N. (2021) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2020.11.013 · Cited by 11
Daniels, A., Wellan, S. A., & Walter, H. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100200 · Cited by 9
Yilmaz, M., Psychogiou, L., Ford, T. J., & Dunn, B. D. (2021) · Journal of Adolescence · doi:10.1016/j.adolescence.2021.07.007 · Cited by 9
Chiba, S., Numakawa, T., Murata, T., Kawaminami, M., & Himi, T. (2022) · Journal of Veterinary Medical Science · doi:10.1292/jvms.22-0103 · Cited by 8
Apathy in depression: An arterial spin labeling perfusion MRI study
Batail, J.-M. V., Corouge, I., Combès, B., Conan, C., Guillery-Sollier, M., Vérin, M., Sauleau, P., Jeune, F. L., Gauvrit, J., Robert, G., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.11.015 · Cited by 10
Lindenbach, D., Seamans, J. K., & Phillips, A. G. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.09.002 · Cited by 8
Vidaña, A. G., Forbes, C. N., Gratz, K. L., & Tull, M. T. (2019) · Addictive Behaviors · doi:10.1016/j.addbeh.2019.106181 · Cited by 8
Somalwar, A. R., Choudhary, A. G., Balasubramanian, N., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146595 · Cited by 8
A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythmPreprint
Mehrhof, S. Z., & Nord, C. L. (2024) · eLife · doi:10.7554/elife.96803 · Cited by 11
Anhedonia in trauma related disorders: the good, the bad, and the shut-down
DePierro, J. M., D’Andrea, W., & Frewen, P. (2014) · Anhedonia: A Comprehensive Handbook Volume II · doi:10.1007/978-94-017-8610-2_7 · Cited by 7
Treating Motivational and Consummatory Aspects of Anhedonia
Treadway, M. T. (2023) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20230008 · Cited by 8
Self-citationBeatty, C. C., Gair, K. A., Anatala, J., Klein, D. N., Hajcak, G., & Nelson, B. D. (2024) · Psychological Medicine · doi:10.1017/s0033291723003720 · Cited by 7
Song, L., Li, S., Zhao, Q., Zhang, W., Sun, X., Niu, L., & Bai, Y. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119987 · Cited by 7
Goubran, M., van Allen, Z., Bilodeau, M., & Boisgontier, M. P. (2025) · Physical Therapy · doi:10.1093/ptj/pzaf120 · Cited by 7
Shehada, D. J. M., Tawfik, H., Bouridane, A., & Hussain, A. J. (2025) · Sensors · doi:10.3390/s25237320 · Cited by 7
Zwiep, J. C., Lamers, F., Vinkers, C. H., van der Wee, N. J. A., Penninx, B. W. J. H., Nawijn, L., & Milaneschi, Y. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106240 · Cited by 12
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 10
Sluggish retrieval of positive memories in depressed adults
Maksimovskiy, A. L., Okine, C., Cataldo, A. M., & Dillon, D. G. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-01010-2 · Cited by 7
Reduced neural responses to reward reflect anhedonia and inattention: an ERP study
Liu, Z., Wang, M., Zhou, X., Qin, S., Zeng, Z., & Zhang, Z. (2022) · Scientific Reports · doi:10.1038/s41598-022-21591-9 · Cited by 7
Sudol, K., Conway, C. M., Szymkowicz, S. M., Elson, D. M., Kang, H., & Taylor, W. D. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.06.003 · Cited by 7
Psychopathy, Machiavellianism, and sleep patterns as predictors of adolescent depression
Paknejad, N., & Mazandarani, A. A. (2023) · Current Psychology · doi:10.1007/s12144-023-05467-3 · Cited by 7
Yeung, R. C., Danckert, J. A., van Tilburg, W. A. P., & Fernandes, M. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-52495-5 · Cited by 8
Carpita, B., Nardi, B., Bonelli, C., Pascariello, L., Massimetti, G., Cremone, I. M., Pini, S., Palego, L., Betti, L., Giannaccini, G., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12071529 · Cited by 7
A Cognitive‐Behavioral Model of Apathy in Parkinson’s Disease
Plant, O., Kienast, A., Drew, D. S., Slavkova, E. D., Muhammed, K., Kennerley, H., & Masud Husain, B. (2024) · Parkinson s Disease · doi:10.1155/2024/2820257 · Cited by 7
Relationships Between Adolescent Perception of Family Functioning and Affective Symptomatology
Nguyen, T. N. B., Chance, A. B., Roske, C., Chase, E., Rubinstein, T. B., Zayde, A., Mowrey, W. B., & Gabbay, V. (2024) · JAACAP Open · doi:10.1016/j.jaacop.2024.09.002 · Cited by 7
Recognising depression in non-human primates: a narrative review of reported signs of depression
van Oosten, J. C. P., Ploeger, A., & Sterck, E. H. M. (2025) · PeerJ · doi:10.7717/peerj.18766 · Cited by 7
Motivational disturbances in rodent models of neuropsychiatric disorders
Canonica, T., & Zalachoras, I. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.940672 · Cited by 8
Proudfoot, K. L. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-23194 · Cited by 8
Simmons, W. K., & Drevets, W. C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.023 · Cited by 7
Investigating subtypes of reward processing deficits as trait markers for depression
Frey, A.-L., Malinowska, L., Harley, K., Salhi, L., Iqbal, S., Sharma, S., & McCabe, C. (2015) · Translational Developmental Psychiatry · doi:10.3402/tdp.v3.27517 · Cited by 7
Neuroimaging and Neurocircuitry of Obsessive-Compulsive Disorder and Major Depressive Disorder
Ducharme, S., Dougherty, D. D., & Drevets, W. C. (2016) · Springer eBooks · doi:10.1007/978-1-59745-495-7_3 · Cited by 8
Modeling Affective Symptoms of Schizophrenia
Čulig, L., & Belzung, C. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00007-9 · Cited by 8
Networks in Mood and Anxiety Disorders
Hamid, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-415804-7.00024-1 · Cited by 7
Anhedonia as a basic syndrome and a target for treatment for depressive disorder
Mazo, G. E., & Kibitov, A. O. (2019) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2019-3-10-18 · Cited by 8
Coch, C., Viviani, R., Breitfeld, J., Münzer, K., Daßler‐Plenker, J., Holdenrieder, S., Coenen, M., Steffens, M., Müller, M., Hartmann, G., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102020 · Cited by 7
Individualized Treatment Strategy for Depressive Disorder
Chen, J., & Hu, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_12 · Cited by 7
Молекулярно-биологические аспекты депрессивных состояний: современный взгляд на проблему
Ushakova, V. M., Морозова, А. Ю., Reznik, A. M., Kostyuk, G. P., & Chekhonin, V. P. (2020) · Molecular Biology · doi:10.31857/s0026898420050110 · Cited by 8
Smetter, J., Antler, C. A., Young, M. A., & Rohan, K. J. (2021) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-020-09861-0 · Cited by 8
Maternal Depression and Mother-Child Oxytocin Synchrony in Youth with Anxiety Disorders
Polack, R. G., Joormann, J., Orbach, M., Silverman, W. K., & Lebowitz, E. R. (2021) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-020-00744-2 · Cited by 8
Beckenstrom, A. C., Coloma, P. M., Dawson, G. R., Finlayson, A., Malik, A., Post, A., Steiner, M. A., & Potenza, M. N. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105107 · Cited by 7
Meng, Q., Garcia‐García, Á. L., Dranovsky, A., & Leonardo, E. D. (2023) · Scientific Reports · doi:10.1038/s41598-023-29175-x · Cited by 7
Anhedonia in combat veterans with penetrating head injury
Lewis, J. D., Krüeger, F., Raymont, V., Solomon, J. M., Knutson, K. M., Barbey, A. K., Poore, J., Wassermann, E. M., & Grafman, J. H. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9414-4 · Cited by 7
Salamone, J. D., Correa, M., Randall, P. A., Nunes, E. J., Pardo, M., & López‐Cruz, L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3903-5_23 · Cited by 7
Lees, T., & Gatzke‐Kopp, L. M. (2025) · Psychophysiology · doi:10.1111/psyp.70026 · Cited by 6
Zeng, Q.-B., Huang, X., Xu, R., Shang, D., Huang, S., Huang, X., Yang, X.-H., Balbuena, L., Xiang, Y., & Zheng, W. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.041 · Cited by 10
Fedorenko, E. J., Barnwell, P. V., Selby, E. A., & Contrada, R. J. (2023) · Biological Psychology · doi:10.1016/j.biopsycho.2023.108499 · Cited by 6
Tandon, T., Piccolo, M., Ledermann, K., Gupta, R., Morina, N., & Martin-Söelch, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-24821-2 · Cited by 6
Lin, J., Yang, X., Li, H., Lin, W., Zhang, J., & Lei, Y. (2024) · Depression and Anxiety · doi:10.1155/2024/3135532 · Cited by 8
Lopes, I. S., Souza, A. G., Filho, A. J. M. C., Sampaio, T. L., da Silva, D. M. A., Valentim, J. T., Chaves, R. D. C., Soares, M. V. R., Júnior, D. C. C., Barbosa‐Filho, J. M., et al. (2024) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000788 · Cited by 7
Delivering a new generation of translational animal models for depression research
Robinson, E. S. J. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000819 · Cited by 6
Pini, S., Milrod, B., Nardi, B., Massimetti, G., Bonelli, C., Baldwin, D. S., Domschke, K., Schiele, M., Dell'Osso, L., & Carpita, B. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.108 · Cited by 3
Dynamic changes in network structure of depressive symptoms: a two-year naturalistic follow-up study
Shen, G., Yang, X., Zou, Y., Zheng, Y., Fang, J., Huang, J., Tang, J., Wu, S., & Chen, L. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07124-4 · Cited by 8
Коморбидные сочетания алкогольной зависимости и депрессивных расстройств
Rozin, A., Рощина, О. В., Peshkovskaya, A. G., & Игоревич, Б. И. (2018) · Сибирский вестник психиатрии и наркологии · doi:10.26617/1810-3111-2018-4(101)-40-45 · Cited by 6
Depression in Climacteric Women: Most Meaningful Symptoms
Figueira, O. A., Figueira, H. A., Figueira, J. A., Garcia, A. A., Figueira, A. A., Neto, G. D. A. M., & Dantas, E. H. M. (2019) · Health · doi:10.4236/health.2019.114034 · Cited by 6
Apathy in melancholic depression and abnormal neural activity within the reward-related circuit
Jiang, Y. B., Zhang, T., Zhang, M., Xie, X., Tian, Y., Wang, K., & Bai, T. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114379 · Cited by 6
Yan, Y., Hu, H., Zhang, Y.-J., Wang, L., Pan, Y., Lui, S. S. Y., Huang, J., & Chan, R. C. K. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01640-8 · Cited by 6
Metadata
- Authors
- Treadway, M. T., & Zald, D. H.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Treadway, Michael T.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 35
- Issue
- 3
- Pages
- 537-555
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC3005986
- OpenAlex
- W2049882268
- Cited by
- 1,579
- References
- 357
- Citations by year
- 2026: 154 · 2025: 141 · 2024: 107 · 2023: 120 · 2022: 93 · 2021: 109 · 2020: 158 · 2019: 107 · 2018: 118 · 2017: 95 · 2016: 93 · 2015: 92 · 2014: 74 · 2013: 51 · 2012: 48
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (F31MH087015)
- National Institute on Drug Abuse (R01DA019670)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anhedonia, major depressive disorder, dopamine, reward motivation, translational neuroscience
- MeSH terms
- Animals, Depression, Dopamine, Humans, Motivation, Neurosciences, Reward, Translational Research, Biomedical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
