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Reconsidering anhedonia in depression: Lessons from translational neuroscience
Open accessAbstract
Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. Given substantial preclinical evidence that DA is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. Moreover, bridging the gap between preclinical and clinical models of anhedonia may require moving away from the conceptualization of anhedonia as a steady-state, mood-like phenomena. Consequently, we introduce the term "decisional anhedonia" to address the influence of anhedonia on reward decision-making. These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD.
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“Anhedonia and impaired reward circuit pathways are associated with a poorer prognosis and suboptimal treatment response (Buckner et al., 2008;Uher et al., 2012;Treadway and Zald, 2011).”
From Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment (2021) · cites this paper as Treadway and Zald, 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“studies of the neurobiology of reward processing have highlighted the variety of distinct pathways involved in its different aspects resulting in the recognition of separate subtypes of anhedonia, including consummatory, anticipatory, motivational and decisional [20,21].”
From Prefrontal cortex and depression (2022) · cites this paper as [20]
Experimental — accuracy not yet measuredIn the citing paper
“Anhedonia is a broad construct that includes deficits in anticipation of, motivation toward, and responsiveness to reward, as well as deficits in reward learning (ability to recall and make decisions based on past rewarding experiences) (Treadway and Zald, 2011) and is estimated to be 46% heritable in studies of monozygotic twins (Bogdan and Pizzagalli, 2009).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“hyposensitivity to reward and hypersensitivity to punishment have been a consistent finding in depression”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Treadway and Zald 2011
In the citing paper
“Dysregulation of dopamine release in motivating responses to rewarding and aversive stimuli, as well as cognitive demand, is a plausible mechanistic cause that can explain a range of depression symptoms [24][25][26][27][28][29].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [25]
In the citing paper
“Particularly relevant in the present context are previous reports [290,296,297] that although both DA and non-DA agents can be used to effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia, specifically when compared with non-DA agents [19,298-300].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“The mesolimbic DA system represents only one component of a very complex and integrated set of circuits, and although DA is clearly a crucial neurotransmitter in the reward-processing system, non-DA systems clearly also modulate reward responsibility [19,735].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“Additionally, multiple non-DA compounds have shown efficacy in improving reward responses, such as agents that affect glutamate circuits involved in regulating monoamine systems [19].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
In the citing paper
“However, recent studies suggest that many patients with schizophrenia or Parkinson’s, and possibly some with major depression, are not actually anhedonic after all: they report normal sensory pleasure ratings of ice cream or other sensory reward in the moment, even though they attach little value to any sensory, social or other pleasant reward in life.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“Some investigators therefore have suggested their deficit really reflects a selective loss of incentive motivation or ‘wanting,’ rather than loss of pleasure ‘liking’ (Sienkiewicz-Jarosz et al., 2005; Dowd and Barch, 2010; Treadway and Zald, 2011; Barch et al., 2014).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
In the citing paper
“Anhedonia typically does not respond to first-line pharmacotherapies [5, 7, 8]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [5]
In the citing paper
“co-morbid traits, such as depression, anxiety, or inattention/hyperactivity, are often associated with ASD [212], and are known to affect general reward processing [213,214] and intervention response [215].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [213]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1×
“Introduction With a lifetime prevalence of approximately 16% (Kessler et al., 2003), Major Depressive Disorder (MDD) is predicted to become the second leading cause of death and disability in the United States by the year 2020 (Murray and Lopez, 1997).”
BackgroundGray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Research works printed but not linked: 1
- Schoenbaum, 2003, A systems approach to orbitofrontal cortex reveal interactions with different learning systems, 146, 19
Cited by
Sorted by citations
Items 201–300 of 1,001
Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93
Greenberg, T., Chase, H. W., Almeida, J. R., Stiffler, R., Zevallos, C. R., Aslam, H. A., Deckersbach, T., Weyandt, S., Cooper, C., Toups, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14050594 · Cited by 93
Markou, A., Salamone, J. D., Bussey, T. J., Mar, A. C., Brunner, D., Gilmour, G., & Balsam, P. D. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.007 · Cited by 95
FAWCETT, J. A., Rush, A. J., Vukelich, J., Diaz, S. H., Dunklee, L., Romo, P. E., Yarns, B. C., & Escalona, R. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15060788 · Cited by 94
Dunn, B. D., German, R. E., Khazanov, G., Xu, C., Hollon, S. D., & DeRubeis, R. J. (2020) · Clinical Psychological Science · doi:10.1177/2167702619863427 · Cited by 92
Symposium review: Scientific assessment of affective states in dairy cattle
Ede, T., Lecorps, B., von Keyserlingk, M. A. G., & Weary, D. M. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16325 · Cited by 102
The role of dopamine in the pathophysiology and treatment of apathy
Chong, T. T. ‐., & Husain, M. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.05.007 · Cited by 93
Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., Dos-Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V. I., Blanco, H., Martínez‐Villayandre, B., et al. (2013) · Neural Plasticity · doi:10.1155/2013/537265 · Cited by 90
Increasing anticipated and anticipatory pleasure through episodic thinking.
Hallford, D. J., Farrell, H., & Lynch, E. (2020) · Emotion · doi:10.1037/emo0000765 · Cited by 98
Anhedonia in Depressive Disorder: A Narrative Review
Fruyt, J. D., Sabbe, B., & Demyttenaere, K. (2020) · Psychopathology · doi:10.1159/000508773 · Cited by 97
Dysregulation of brain dopamine systems in major depressive disorder
Delva, N. C., & Stanwood, G. D. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221991830 · Cited by 96
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89
Self-citationReward Network Modulation as a Mechanism of Change in Behavioral Activation
Nagy, G. A., Cernasov, P., Pisoni, A., Walsh, E. C., Dichter, G. S., & Smoski, M. J. (2018) · Behavior Modification · doi:10.1177/0145445518805682 · Cited by 98
Xie, W., Li, H., Luo, X., Fu, R., Ying, X., Wang, N., Yin, Q.-F., Zou, Y.-M., Cui, Y., Wang, X., et al. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.22055 · Cited by 89
Influence of Omega-3 Fatty Acid Status on the Way Rats Adapt to Chronic Restraint Stress
Hennebelle, M., Balasse, L., Latour, A., Champeil‐Potokar, G., Denis, S., Lavialle, M., Gisquet-Verrier, P., Denis, I., & Vancassel, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042142 · Cited by 91
Greenberg, G. D., Laman-Maharg, A., Campi, K. L., Voigt, H., Orr, V. N., Schaal, L., & Trainor, B. C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00223 · Cited by 89
Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention
Nollet, M., & Leman, S. (2013) · CNS Drugs · doi:10.1007/s40263-013-0064-z · Cited by 89
Reduced hedonic capacity in euthymic bipolar subjects: a trait-like feature
Di Nicola, M., De Risio, L., Battaglia, C., Camardese, G., Tedeschi, D., Mazza, M., Martinotti, G., Pozzi, G., Niolu, C., Di Giannantonio, M., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.004 · Cited by 87
Zhu, C., Zhang, Y., Wang, T., Lin, Y., Yu, J., Xia, Q., Zhu, P., & Zhu, D. (2020) · Brain and Behavior · doi:10.1002/brb3.1760 · Cited by 92
Association of opioid misuse with anxiety and depression: A systematic review of the literature
Rogers, A. H., Zvolensky, M. J., Ditre, J. W., Buckner, J. D., & Asmundson, G. J. G. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101978 · Cited by 93
The Urge to Decide and Act: Implications for Brain Function and Dysfunction
Carland, M. A., Thura, D., & Cisek, P. (2019) · The Neuroscientist · doi:10.1177/1073858419841553 · Cited by 84
The Association between Anhedonia, Suicidal Ideation, and Suicide Attempts in a Large Student Sample
Winer, E. S., Drapeau, C. W., Veilleux, J. C., & Nadorff, M. R. (2015) · Archives of Suicide Research · doi:10.1080/13811118.2015.1025119 · Cited by 86
Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review
Destoop, M., Morrens, M., Coppens, V., & Dom, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00311 · Cited by 85
Forbes, C. N. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101860 · Cited by 90
Liao, S., Zhou, Y., Liu, Y., & Wang, R. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.04.022 · Cited by 87
Seaman, K. L., Gorlick, M. A., Vekaria, K. M., Hsu, M., Zald, D. H., & Samanez-Larkin, G. R. (2016) · Psychology and Aging · doi:10.1037/pag0000131 · Cited by 84
Self-citationHallford, D. J., & Sharma, M. K. (2019) · British Journal of Clinical Psychology · doi:10.1111/bjc.12218 · Cited by 84
Cooper, J. A., Barch, D. M., Reddy, L. F., Horan, W. P., Green, M. F., & Treadway, M. T. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000443 · Cited by 85
Self-citationWhy extraverts are happier: A day reconstruction study
Oerlemans, W. G. M., & Bakker, A. B. (2014) · Journal of Research in Personality · doi:10.1016/j.jrp.2014.02.001 · Cited by 88
Rappaport, B. I., Kandala, S., Luby, J. L., & Barch, D. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19030281 · Cited by 83
Neurobiological basis of motivational deficits in psychopathology
Salamone, J. D., Koychev, I. G., Correa, M., & McGuire, P. K. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.014 · Cited by 87
Kalmbach, D. A., Kingsberg, S. A., & Ciesla, J. A. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12692 · Cited by 82
Patients with major depressive disorder exhibit reduced reward size coding in the striatum
Takamura, M., Okamoto, Y., Okada, G., Toki, S., Yamamoto, T., Ichikawa, N., Mori, A., Minagawa, H., Takaishi, Y., Fujii, Y., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.006 · Cited by 81
Wray-Lake, L., Shubert, J., Lin, L., & Starr, L. R. (2019) · Applied Developmental Science · doi:10.1080/10888691.2017.1326825 · Cited by 81
Neural substrates underlying effort computation in schizophrenia
Fervaha, G., Foussias, G., Agid, O., & Remington, G. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.001 · Cited by 86
Anhedonia in melancholic and non-melancholic depressive disorders
Fletcher, K., Parker, G. B., Paterson, A., D, M. F. M., Iosifescu, D. V., & Pizzagalli, D. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.028 · Cited by 84
Symptoms of anhedonia, not depression, predict the outcome of treatment of cocaine dependence
Crits-Christoph, P. F., Wadden, S., Gaines, A. N., Rieger, A., Gallop, R., McKay, J. R., & Gibbons, M. B. C. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.06.010 · Cited by 83
Ho, N., & Sommers, M. S. (2013) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2013.02.001 · Cited by 88
Huys, Q. J. M., Guitart‐Masip, M., Dolan, R. J., & Dayan, P. (2015) · Clinical Psychological Science · doi:10.1177/2167702614562040 · Cited by 85
Yohn, S. E., Collins, S. L., Contreras-Mora, H. M., Errante, E. L., Rowland, M. A., Correa, M., & Salamone, J. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.188 · Cited by 81
Page, C. E., Epperson, C. N., Novick, A. M., Duffy, K. A., & Thompson, S. M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02625-2 · Cited by 80
Pacheco-Colón, I., Limia, J. M., & Gonzalez, R. (2018) · Psychology of Addictive Behaviors · doi:10.1037/adb0000380 · Cited by 82
Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder
Wardle, M. C., Vincent, J. N., Suchting, R., Green, C. E., Lane, S. D., & Schmitz, J. M. (2016) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2016.08.020 · Cited by 80
Zhang, D., Shen, J., Bi, R., Zhang, Y., Zhou, F., Feng, C., & Gu, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720003967 · Cited by 82
Roberts, A. C., & Clarke, H. F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902288116 · Cited by 79
Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02922-y · Cited by 79
Evidence that anhedonia is a symptom of opioid dependence associated with recent use
Garfield, J. B. B., Cotton, S., Allen, N. B., Cheetham, A., Kras, M., Yücel, M., & Lubman, D. I. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.03.012 · Cited by 79
The Positive Valence Systems Scale: Development and Validation
Khazanov, G. K., Ruscio, A. M., & Forbes, C. N. (2019) · Assessment · doi:10.1177/1073191119869836 · Cited by 83
Liu, R., Wang, Y., Chen, X., Zhang, Z., Xiao, L., & Zhou, Y. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102599 · Cited by 84
Development and validation of the Specific Loss of Interest and Pleasure Scale (SLIPS)
Winer, E. S., Veilleux, J. C., & Ginger, E. J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.010 · Cited by 83
Scharnowski, F., Nicholson, A. A., Pichon, S., Rosa, M. J., Rey, G., Eickhoff, S. B., Ville, D. V. D., Vuilleumier, P. O., & Koush, Y. (2020) · Human Brain Mapping · doi:10.1002/hbm.25001 · Cited by 83
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression
Papp, M., Gruca, P., Łasoń, M., Adham, N., Kiss, B., & Gyertyán, I. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000070 · Cited by 81
Darcet, F., Gardier, A. M., Gaillard, R., David, D. J. P., & Guilloux, J. (2016) · Pharmaceuticals · doi:10.3390/ph9010009 · Cited by 85
Temporal dynamics of reward anticipation in the human brain
Zhang, Y., Li, Q., Wang, Z., Liu, X., & Zheng, Y. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.07.011 · Cited by 83
Starr, L. R., Hershenberg, R., Li, Y. I., & Shaw, Z. A. (2017) · Clinical Psychological Science · doi:10.1177/2167702617694657 · Cited by 98
Hallford, D. J., Sharma, M. K., & Austin, D. (2020) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-020-09820-9 · Cited by 85
Intense Beauty Requires Intense Pleasure
Brielmann, A. A., & Pelli, D. G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02420 · Cited by 81
Levodopa Reverses Cytokine-Induced Reductions in Striatal Dopamine Release
Felger, J. C., Hernandez, C. R., & Miller, A. H. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu084 · Cited by 77
Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging
Zald, D. H., & Lahey, B. B. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.02.003 · Cited by 79
Self-citationNeutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity
Meye, F. J., Trezza, V, Vanderschuren, L. J. M. J., Ramakers, G. M. J., & Adan, R. A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.145 · Cited by 76
Yohn, S. E., Errante, E. L., Rosenbloom-Snow, A., Somerville, M., Rowland, M. A., Tokarski, K., Zafar, N., Correa, M., & Salamone, J. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.06.018 · Cited by 76
Treadway, M. T., & Pizzagalli, D. A. (2014) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-4-5 · Cited by 79
Self-citationA computational analysis of flanker interference in depression
Dillon, D. G., Wiecki, T. V., Pechtel, P., Webb, C. A., Goer, F., Murray, L., Trivedi, M. H., D, M. F. M., McGrath, P. J., Weissman, M. M., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715000276 · Cited by 76
Guillot, C. R., Bello, M. S., Tsai, J., Huh, J., Leventhal, A. M., & Sussman, S. Y. (2016) · Computers in Human Behavior · doi:10.1016/j.chb.2016.04.019 · Cited by 76
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Burstein, O., & Doron, R. (2018) · Journal of Visualized Experiments · doi:10.3791/58184 · Cited by 82
Lee, Y. L., Mansur, R. B., Brietzke, E. M., Carmona, N. E., Subramaniapillai, M., Pan, Z., Shekotikhina, M., Rosenblat, J. D., Suppes, T. M., Cosgrove, V. E., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.063 · Cited by 75
Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity
Wang, J., Huang, J., Yang, X., Lui, S. S. Y., Cheung, E. F. C., & Chan, R. C. K. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.019 · Cited by 86
Bergamini, G., Mechtersheimer, J., Azzinnari, D., Sigrist, H., Buerge, M., Dallmann, R., Freije, R., Kouraki, A., Opacka‐Juffry, J., Seifritz, E., et al. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.01.004 · Cited by 77
Yohn, S. E., López‐Cruz, L., Hutson, P. H., Correa, M., & Salamone, J. D. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4176-7 · Cited by 76
Ballard, E. D., Yarrington, J. S., Farmer, C., Lener, M. S., Kadriu, B., Lally, N., Williams, D., Machado‐Vieira, R., Niciu, M. J., Park, L., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.01.027 · Cited by 78
Kroemer, N. B., Guevara, A., Ciocanea Teodorescu, I., Wuttig, F., Kobiella, A., & Smolka, M. N. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.07.060 · Cited by 64
Common and distinct neural targets of treatment: Changing brain function in substance addiction
Konova, A. B., Moeller, S. J., & Goldstein, R. Z. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.002 · Cited by 78
Dopamine and Food Addiction: Lexicon Badly Needed
Salamone, J. D., & Correa, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.027 · Cited by 77
Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity
Kroemer, N. B., & Small, D. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.020 · Cited by 74
Pictet, A., Jermann, F., & Ceschi, G. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.07.008 · Cited by 79
Sun, Y., Drevets, W. C., Turecki, G., & Li, Q. S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.011 · Cited by 70
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Wu, C., Dillon, D. G., Hsu, H.-C., Huang, S., Barrick, E. M., & Liu, Y. (2018) · Applied Sciences · doi:10.3390/app8081244 · Cited by 74
Ning, L., Makris, N., Camprodon, J. A., & Yogesh Rathi, A. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.10.004 · Cited by 71
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Higgins, G. A., Carroll, N. K., Brown, M., MacMillan, C., Silenieks, L. B., Thevarkunnel, S., Izhakova, J., Magomedova, L., DeLannoy, I., & Sellers, E. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.640241 · Cited by 72
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Neural substrates of the impaired effort expenditure decision making in schizophrenia.
Huang, J., Yang, X., Lan, Y., Cui-ying, Z., Liu, X.-Q., Wang, Y., Cheung, E. F. C., Xie, G., & Chan, R. C. K. (2016) · Neuropsychology · doi:10.1037/neu0000284 · Cited by 76
Yang, X., Tian, K., Wang, D., Wang, Y., Cheung, E. F. C., Xie, G., & Chan, R. C. K. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.053 · Cited by 74
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Prakash, N., Stark, C. J., Keisler, M. N., Luo, L., Der‐Avakian, A., & Dulcis, D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1802-19.2019 · Cited by 72
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Soutschek, A., Kang, P., Ruff, C. C., Hare, T. A., & Tobler, P. N. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.007 · Cited by 68
Rzepa, E., Fisk, J., & McCabe, C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116681416 · Cited by 68
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Self-citationSocial defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats
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Metadata
- Authors
- Treadway, M. T., & Zald, D. H.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Treadway, Michael T.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 35
- Issue
- 3
- Pages
- 537-555
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC3005986
- OpenAlex
- W2049882268
- Cited by
- 1,579
- References
- 357
- Citations by year
- 2026: 154 · 2025: 141 · 2024: 107 · 2023: 120 · 2022: 93 · 2021: 109 · 2020: 158 · 2019: 107 · 2018: 118 · 2017: 95 · 2016: 93 · 2015: 92 · 2014: 74 · 2013: 51 · 2012: 48
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (F31MH087015)
- National Institute on Drug Abuse (R01DA019670)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anhedonia, major depressive disorder, dopamine, reward motivation, translational neuroscience
- MeSH terms
- Animals, Depression, Dopamine, Humans, Motivation, Neurosciences, Reward, Translational Research, Biomedical
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