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Cited by 472

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

Oxidative stress in schizophrenia: An integrated approach

Open access
Bitanihirwe, Byron K.Y., Woo, Tsung-Ung W.·2011·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2010.10.008
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Abstract

Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia. In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is known to impair cell viability and function, which may subsequently account for the deteriorating course of the illness. Currently available evidence points towards an alteration in the activities of enzymatic and nonenzymatic antioxidant systems in schizophrenia. In fact, experimental models have demonstrated that oxidative stress induces behavioural and molecular anomalies strikingly similar to those observed in schizophrenia. These findings suggest that oxidative stress is intimately linked to a variety of pathophysiological processes, such as inflammation, oligodendrocyte abnormalities, mitochondrial dysfunction, hypoactive N-methyl-D-aspartate receptors and the impairment of fast-spiking gamma-aminobutyric acid interneurons.[bkyb1] Such self-sustaining mechanisms may progressively worsen producing the functional and structural consequences associated with schizophrenia. Recent clinical studies have shown antioxidant treatment to be effective in ameliorating schizophrenic symptoms. Hence, identifying viable therapeutic strategies to tackle oxidative stress and the resulting physiological disturbances provide an exciting opportunity for the treatment and ultimately prevention of schizophrenia.

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Metadata

Authors
Bitanihirwe, B. K. Y., & Woo, T.-U. W.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2011-01
Volume
35
Issue
3
Pages
878-893
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2010.10.008
OpenAlex
W1965707086
Cited by
472
References
322
FWCI
14.75
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Oxidative stress in schizophrenia: An integrated approach. https://app.cochat.ai/papers/10.1016/j.neubiorev.2010.10.008
The paper
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2011). Oxidative stress in schizophrenia: An integrated approach. Neuroscience & Biobehavioral Reviews. https://doi.org/10.1016/j.neubiorev.2010.10.008

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.