The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Open accessAbstract
BACKGROUND: Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome. DISCUSSION: While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson's disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines. SUMMARY: This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders.
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These pleiotropic effects indicate that coenzyme Q10 may hold promise as a cognitive enhancer for neuro-immune diseases in which mitochondrial dysfunction is a pathophysiological hallmark, including but not limited to major depressive disorder.
“These pleiotropic effects indicate that CoQ10 may hold promise as a cognitive enhancer for neuro-immune diseases in which mitochondrial dysfunction is a pathophysiological hallmark, including but not limited to MDD [182].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [182]
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- Authors
- Morris, G., & Berk, M.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Morris, Gerwyn
- ORCID
- Morris, Gerwyn
- Venue
- BMC Medicine
- Published
- 2015-04-01
- Volume
- 13
- Issue
- 1
- Pages
- 68-68
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC4382850
- OpenAlex
- W1978853745
- Cited by
- 245
- References
- 508
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 16 · 2023: 18 · 2022: 16 · 2021: 16 · 2020: 30 · 2019: 19 · 2018: 31 · 2017: 31 · 2016: 34 · 2015: 4
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (1059660)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- mitochondrial dysfunction, oxidative metabolism, neuroimmunological diseases, neuropsychiatric disorders, chronic oxidative stress, reactive oxygen species, reactive nitrogen species, glutathione, inflammatory cytokines, systemic inflammation, multiple sclerosis, Parkinson's disease, bipolar disorder, schizophrenia, depression, autism spectrum disorder, chronic fatigue syndrome
- MeSH terms
- Autistic Disorder, Mental Disorders, Bipolar Disorder, Depressive Disorder, Female, Humans, Mitochondria, Multiple Sclerosis, Parkinson Disease, Schizophrenia, Neuroimmunomodulation, Fatigue Syndrome, Chronic, Oxidative Stress, Mitochondrial Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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