The DOI matches its Crossref record; 270 of the 273 references it cites were found in a registry or an index.
Serotonin and decision making processes
Abstract
Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant, anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric disorders characterized by impaired decision making, and exert both beneficial and harmful effects in patients. Detailed insight into the serotonergic mechanisms underlying decision making is needed to strengthen the first and weaken the latter. Although much remains to be done to achieve this, accumulating studies begin to deliver a coherent view. Thus, high central 5-HT levels are generally associated with improved reversal learning, improved attentional set shifting, decreased delay discounting, and increased response inhibition, but a failure to use outcome representations. Based on 5-HT's evolutionary role, I hypothesize that 5-HT integrates expected, or changes in, relevant sensory and emotional internal/external information, leading to vigilance behaviour affecting various decision making processes. 5-HT receptor subtypes play distinctive roles in decision making. 5-HT(2A) agonists and 5-HT2c antagonists decrease compulsivity, whereas 5-HT(2A) antagonists and 5-HT(2C) agonists decrease impulsivity. 5-HT(6) antagonists univocally affect decision making processes.
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“Mounting evidence suggests that the GM modulates the tryptophan and kynurenine pathways and is a humoral route through which the GM may influence cognition at the level of the CNS (206–210).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [208]
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739
A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei
Pollak Dorocic, I., Fürth, D., Xuan, Y., Johansson, Y., Pozzi, L., Silberberg, G., Carlén, M., & Meletis, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.002 · Cited by 451
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
Metadata
- Authors
- Homberg, J. R.
- Affiliations
- Donders Institute for Brain, Cognition and Behaviour (NL)
- Corresponding author
- Homberg, Judith R.
- ORCID
- Homberg, Judith R.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 36
- Issue
- 1
- Pages
- 218-236
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2015724371
- Cited by
- 167
- References
- 273
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 4 · 2019: 7 · 2018: 27 · 2017: 12 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 23 · 2012: 8
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- The Netherlands Organisation for Scientific Research (NWO) (86410003)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, decision-making, reversal learning, set-shifting, delay discounting, response inhibition, serotonergic receptors, 5-HT2A receptor, 5-HT2C receptor, 5-HT6 receptor, impulsivity, compulsivity, antidepressants, anxiolytics, antipsychotic drugs, vigilance behavior
- MeSH terms
- Animals, Decision Making, Humans, Receptors, Serotonin, Reversal Learning, Serotonin, Serotonin Agents
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